Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Tom van Dooren"'
1
Akademický článek
Modifying Rap1-signalling by targeting Pde6δ is neuroprotective in models of Alzheimer’s disease
Autor: Michael Dumbacher, Tom Van Dooren, Katrien Princen, Koen De Witte, Mélissa Farinelli, Sam Lievens, Jan Tavernier, Wim Dehaen, Stefaan Wera, Joris Winderickx, Sara Allasia, Amuri Kilonda, Stéphane Spieser, Arnaud Marchand, Patrick Chaltin, Casper C. Hoogenraad, Gerard Griffioen
Publikováno v: Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-21 (2018)
Abstract Background Neuronal Ca2+ dyshomeostasis and hyperactivity play a central role in Alzheimer’s disease pathology and progression. Amyloid-beta together with non-genetic risk-factors of Alzheimer’s disease contributes to increased Ca2+ infl
Externí odkaz: https://doaj.org/article/d568da05c95f4ce298de12d9db169d2b
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2
Akademický článek
Enriched biodiversity data as a resource and service
Autor: Rutger Vos, Jordan Biserkov, Bachir Balech, Niall Beard, Matthew Blissett, Christian Brenninkmeijer, Tom van Dooren, David Eades, George Gosline, Quentin Groom, Thomas Hamann, Hannes Hettling, Robert Hoehndorf, Ayco Holleman, Peter Hovenkamp, Patricia Kelbert, David King, Don Kirkup, Youri Lammers, Thibaut DeMeulemeester, Daniel Mietchen, Jeremy Miller, Ross Mounce, Nicola Nicolson, Rod Page, Aleksandra Pawlik, Serrano Pereira, Lyubomir Penev, Kevin Richards, Guido Sautter, David Shorthouse, Marko Tähtinen, Claus Weiland, Alan Williams, Soraya Sierra
Publikováno v: Biodiversity Data Journal, Vol 2, Pp 1-15 (2014)
Background: Recent years have seen a surge in projects that produce large volumes of structured, machine-readable biodiversity data. To make these data amenable to processing by generic, open source “data enrichment” workflows, they are increasin
Externí odkaz: https://doaj.org/article/a4c216c8af8144ecbac7353d7d170885
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3
Akademický článek
Pathological Hallmarks, Clinical Parallels, and Value for Drug Testing in Alzheimer's Disease of the APP[V717I] London Transgenic Mouse Model
Autor: An Tanghe, Annelies Termont, Pascal Merchiers, Stephan Schilling, Hans-Ulrich Demuth, Louise Scrocchi, Fred Van Leuven, Gerard Griffioen, Tom Van Dooren
Publikováno v: International Journal of Alzheimer's Disease, Vol 2010 (2010)
The APP[V717I] London (APP-Ld) mouse model recapitulates important pathological and clinical hallmarks of Alzheimer's disease (AD) and is therefore a valuable paradigm for evaluating therapeutic candidates. Historically, both the parenchymal and vasc
Externí odkaz: https://doaj.org/article/a5197c7e75b44c5e80b34ab6b80b4a30
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4
Enriched biodiversity data as a resource and service
Autor: Niall Beard, Christian Y. Brenninkmeijer, Matthew Blissett, Quentin Groom, Kevin Richards, Soraya Sierra, David Shorthouse, David C. Eades, Nicola Nicolson, Alan Williams, Lyubomir Penev, David King, Peter Hovenkamp, Marko Tähtinen, Bachir Balech, Youri Lammers, Jeremy A. Miller, Hannes Hettling, George Gosline, Thomas Hamann, Rutger A. Vos, Ross Mounce, Ayco Holleman, Daniel Mietchen, Patricia Kelbert, Jordan Biserkov, Robert Hoehndorf, Rod Page, Claus Weiland, Don Kirkup, Thibaut DeMeulemeester, Guido Sautter, Aleksandra Pawlik, Serrano Pereira, Tom van Dooren
Publikováno v: Biodiversity Data Journal, Vol 2, Pp 1-15 (2014)
Biodiversity Data Journal
Biodiversity Data Journal (Online) (2014). doi:10.3897/BDJ.2.e1125
info:cnr-pdr/source/autori:Vos R, Biserkov J, Balech B, Beard N, Blissett M, Brenninkmeijer C, van Dooren T, Eades D, Gosline G, Groom Q, Hamann T, Hettling H, Hoehndorf R, Holleman A, Hovenkamp P, Kelbert P, King D, Kirkup D, Lammers Y, DeMeulemeester T, Mietchen D, Miller J, Mounce R, Nicolson N, Page R, Pawlik A, Pereira S, Penev L, Richards K, Sautter G, Shorthouse D, Tähtinen M, Weiland C, Williams A, Sierra S/titolo:Enriched biodiversity data as a resource and service/doi:10.3897%2FBDJ.2.e1125/rivista:Biodiversity Data Journal (Online)/anno:2014/pagina_da:/pagina_a:/intervallo_pagine:/volume
Biodiversity Data Journal 2: e1125
Biodiversity Data Journal, 2, e1125-e1125
Background: Recent years have seen a surge in projects that produce large volumes of structured, machine-readable biodiversity data. To make these data amenable to processing by generic, open source "data enrichment" workflows, they are increasingly
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b48d359afd318dfcc35cb4e3b941012
http://bdj.pensoft.net/lib/ajax_srv/article_elements_srv.php?action=download_pdf&item_id=1125
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5
Derailed Intraneuronal Signalling Drives Pathogenesis in Sporadic and Familial Alzheimer’s Disease
Autor: Koen De Witte, Tom Van Dooren, Gerard Griffioen, Katrien Princen
Publikováno v: BioMed Research International
BioMed Research International, Vol 2014 (2014)
Although a wide variety of genetic and nongenetic Alzheimer’s disease (AD) risk factors have been identified, their role in onset and/or progression of neuronal degeneration remains elusive. Systematic analysis of AD risk factors revealed that pert
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6fd0c8c814f068106f35c88a93acb0b
https://doi.org/10.1155/2014/167024
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6
Amyloid-β protein modulates the perivascular clearance of neuronal apolipoprotein E in mouse models of Alzheimer's disease
Autor: Gerd Birkenmeier, Ajeet Rijal Upadhaya, Harshvardhan Rolyan, Dietmar Rudolf Thal, Ann Caroline Feike, Tom Van Dooren, Andreas Waha, Christian Haass, Claus U. Pietrzik, Fred Van Leuven
Publikováno v: Journal of neural transmission 118(5), 699-712 (2011). doi:10.1007/s00702-010-0572-7
The deposition of amyloid-β protein (Aβ) in the brain is a hallmark of Alzheimer's disease (AD). Apolipoprotein E (apoE) is involved in the clearance of Aβ from brain and the APOE ε4 allele is a major risk factor for sporadic AD. We have recently
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::547f046e8b35a3f570f9c240f9ee7cd3
https://lirias.kuleuven.be/handle/123456789/297698
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8
Pathological Hallmarks, Clinical Parallels, and Value for Drug Testing in Alzheimer's Disease of the APP[V717I] London Transgenic Mouse Model
Autor: Stephan Schilling, Tom Van Dooren, Fred Van Leuven, An Tanghe, Annelies Termont, Louise Scrocchi, Pascal Merchiers, Gerard Griffioen, Hans-Ulrich Demuth
Publikováno v: International Journal of Alzheimer's Disease, Vol 2010 (2010)
International Journal of Alzheimer's Disease
The APP[V717I] London (APP-Ld) mouse model recapitulates important pathological and clinical hallmarks of Alzheimer's disease (AD) and is therefore a valuable paradigm for evaluating therapeutic candidates. Historically, both the parenchymal and vasc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ffc4d67ec2582494d8a9a3851756766
https://doaj.org/article/a5197c7e75b44c5e80b34ab6b80b4a30
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9
O2‐03‐03: Phenotypic and genetic subclassification of Alzheimer's disease
Autor: Takaomi C. Saido, Fred Van Leuven, Estifanos Ghebremedhin, Tom Van Dooren, Sue T. Griffin, Dietmar Rudolf Thal, Heike Koelsch, Andreas Papassotiropoulos
Publikováno v: Alzheimer's & Dementia. 5
Background: Two different types of Alzheimer's disease (AD)-related cerebral amyloid angiopathy (CAA) can be distinguished by the presence or absence of capillary amyloid β-protein (Aβ)-deposition. Genetically, CAA-type 1 with capillary CAA is stro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ef18bba9b0dd7c50877201a3873ed42
https://doi.org/10.1016/j.jalz.2009.05.336
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