Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Tom Wurdinger"'
Autor:
Asli Küçükosmanoglu, Carolien L. van derBorden, Lisanne E. A. deBoer, Roel Verhaak, David Noske, Tom Wurdinger, Teodora Radonic, Bart A. Westerman
Publikováno v:
Molecular Oncology, Vol 18, Iss 10, Pp 2407-2422 (2024)
Genetic heterogeneity in tumors can show a remarkable selectivity when two or more independent genetic events occur in the same gene. This phenomenon, called composite mutation, points toward a selective pressure, which frequently causes therapy resi
Externí odkaz:
https://doaj.org/article/2f535455fe3d438d87cea860c9cbc6cf
Autor:
Ravi S. Narayan, Piet Molenaar, Jian Teng, Fleur M. G. Cornelissen, Irene Roelofs, Renee Menezes, Rogier Dik, Tonny Lagerweij, Yoran Broersma, Naomi Petersen, Jhon Alexander Marin Soto, Eelke Brands, Philip van Kuiken, Maria C. Lecca, Kristiaan J. Lenos, Sjors G. J. G. In ‘t Veld, Wessel van Wieringen, Frederick F. Lang, Erik Sulman, Roel Verhaak, Brigitta G. Baumert, Lucas J. A. Stalpers, Louis Vermeulen, Colin Watts, David Bailey, Ben J. Slotman, Rogier Versteeg, David Noske, Peter Sminia, Bakhos A. Tannous, Tom Wurdinger, Jan Koster, Bart A. Westerman
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Drug synergies impact the efficacy of combination therapies but are difficult to identify. Here Narayan et al. describe the drug atlas, a method to predict effective drug combinations from common exclusive drug effects providing a resource for explor
Externí odkaz:
https://doaj.org/article/379bf84492484b43b2eac920159ae273
Autor:
Chantal Scheepbouwer, Ernesto Aparicio-Puerta, Cristina Gomez-Martin, Heleen Verschueren, Monique van Eijndhoven, Laurine E. Wedekind, Stavros Giannoukakos, Nathalie Hijmering, Lisa Gasparotto, Hilde T. van der Galien, Roos S. van Rijn, Eleonora Aronica, Robby Kibbelaar, Vivi M. Heine, Pieter Wesseling, David P. Noske, W. Peter Vandertop, Daphne de Jong, D. Michiel Pegtel, Michael Hackenberg, Tom Wurdinger, Alan Gerber, Danijela Koppers-Lalic
Publikováno v:
Genes & development, 37(5-6), 243-257. Cold Spring Harbor Laboratory Press
Scheepbouwer, C, Aparicio-Puerta, E, Gomez-Martin, C, Verschueren, H, van Eijndhoven, M, Wedekind, L E, Giannoukakos, S, Hijmering, N, Gasparotto, L, van der Galien, H T, van Rijn, R S, Aronica, E, Kibbelaar, R, Heine, V M, Wesseling, P, Noske, D P, Vandertop, W P, de Jong, D, Pegtel, D M, Hackenberg, M, Wurdinger, T, Gerber, A & Koppers-Lalic, D 2023, ' ALL-tRNAseq enables robust tRNA profiling in tissue samples ', Genes and Development, vol. 37, no. 5-6, pp. 243-257 . https://doi.org/10.1101/gad.350233.122
Genes and Development, 37(5-6), 243-257. Cold Spring Harbor Laboratory Press
Scheepbouwer, C, Aparicio-Puerta, E, Gomez-Martin, C, Verschueren, H, van Eijndhoven, M, Wedekind, L E, Giannoukakos, S, Hijmering, N, Gasparotto, L, van der Galien, H T, van Rijn, R S, Aronica, E, Kibbelaar, R, Heine, V M, Wesseling, P, Noske, D P, Vandertop, W P, de Jong, D, Pegtel, D M, Hackenberg, M, Wurdinger, T, Gerber, A & Koppers-Lalic, D 2023, ' ALL-tRNAseq enables robust tRNA profiling in tissue samples ', Genes and Development, vol. 37, no. 5-6, pp. 243-257 . https://doi.org/10.1101/gad.350233.122
Genes and Development, 37(5-6), 243-257. Cold Spring Harbor Laboratory Press
Transfer RNAs (tRNAs) are small adaptor RNAs essential for mRNA translation. Alterations in the cellular tRNA population can directly affect mRNA decoding rates and translational efficiency during cancer development and progression. To evaluate chang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1b9244df37517aa537b551f1c722c3d
http://www.scopus.com/inward/record.url?scp=85151574209&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85151574209&partnerID=8YFLogxK
Autor:
D. Michiel Pegtel, Nicola Baldini, Tom Wurdinger, Sulev Köks, Katre Maasalu, Aare Martson, Vincenzo Canzonieri, Agostino Steffan, Silvia Cervo, Nicoletta Zini, Tanja D. de Gruijl, Sinead M. Lougheed, Roberta Bonafede, Massimo Dominici, Giulia Grisendi, Monique A.J. van Eijndhoven, Michelina Greco, Laura Roncuzzi, Ekaterina S. Jordanova, Anne-Marie Cleton-Jansen, Sonia A. Melo, Nicolas Léveillé, Xuan Dung Ho, Maria Pérez-Lanzón, Tonny Lagerweij, S. Rubina Baglio
Supplementary figures and legends and supplementary tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25f2021d751dee43905d9f797bc462c3
https://doi.org/10.1158/1078-0432.22466991.v1
https://doi.org/10.1158/1078-0432.22466991.v1
Autor:
D. Michiel Pegtel, Nicola Baldini, Tom Wurdinger, Sulev Köks, Katre Maasalu, Aare Martson, Vincenzo Canzonieri, Agostino Steffan, Silvia Cervo, Nicoletta Zini, Tanja D. de Gruijl, Sinead M. Lougheed, Roberta Bonafede, Massimo Dominici, Giulia Grisendi, Monique A.J. van Eijndhoven, Michelina Greco, Laura Roncuzzi, Ekaterina S. Jordanova, Anne-Marie Cleton-Jansen, Sonia A. Melo, Nicolas Léveillé, Xuan Dung Ho, Maria Pérez-Lanzón, Tonny Lagerweij, S. Rubina Baglio
Purpose: Human osteosarcoma is a genetically heterogeneous bone malignancy with poor prognosis despite the employment of aggressive chemotherapy regimens. Because druggable driver mutations have not been established, dissecting the interactions betwe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e06e10495adba46e2af40f470d40a695
https://doi.org/10.1158/1078-0432.c.6526500.v1
https://doi.org/10.1158/1078-0432.c.6526500.v1
Autor:
A. Josien Smits, Mohammad Arkani, Sjors G.J.G. In ’t Veld, Anna E. Huis in ‘t Veld, Nik Sol, Joanne A. Groeneveldt, Liza Botros, Natalia J. Braams, Samara M.A. Jansen, Jip Ramaker, Kenn Zwaan, Edward Post, Esther J. Nossent, Anco Boonstra, Frances S. de Man, Anton Vonk Noordegraaf, Jose Gomez-Arroyo, Myron G. Best, Tom Wurdinger, Harm Jan Bogaard
Publikováno v:
Annals of the American Thoracic Society, 19(10), 1650-1660. American Thoracic Society
Smits, A J, Arkani, M, In 't Veld, S G J G, Huis In 't Veld, A E, Sol, N, Groeneveldt, J A, Botros, L, Braams, N J, Jansen, S M, Ramaker, J, Zwaan, K, Post, E, Nossent, E J, Boonstra, A, de Man, F S, Vonk Noordegraaf, A, Gomez-Arroyo, J, Best, M G, Wurdinger, T & Bogaard, H J 2022, ' Distinct Platelet Ribonucleic Acid Signatures in Patients with Pulmonary Hypertension ', Annals of the American Thoracic Society, vol. 19, no. 10, pp. 1650-1660 . https://doi.org/10.1513/AnnalsATS.202201-085OC
Smits, A J, Arkani, M, In 't Veld, S G J G, Huis In 't Veld, A E, Sol, N, Groeneveldt, J A, Botros, L, Braams, N J, Jansen, S M, Ramaker, J, Zwaan, K, Post, E, Nossent, E J, Boonstra, A, de Man, F S, Vonk Noordegraaf, A, Gomez-Arroyo, J, Best, M G, Wurdinger, T & Bogaard, H J 2022, ' Distinct Platelet Ribonucleic Acid Signatures in Patients with Pulmonary Hypertension ', Annals of the American Thoracic Society, vol. 19, no. 10, pp. 1650-1660 . https://doi.org/10.1513/AnnalsATS.202201-085OC
Rationale: Pulmonary hypertension encompasses progressive disorders leading to right ventricular dysfunction and early death. Late detection is an important cause of poor clinical outcomes. However, biomarkers that accurately predict the presence of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::076a86ba587acca852618eb0571a6620
https://pubmed.ncbi.nlm.nih.gov/35537078
https://pubmed.ncbi.nlm.nih.gov/35537078
Autor:
Asli Kucukosmanoglu, Silvia Scoarta, Thomas Wijnands, George Kanev, Bart Westerman, Bert Kiewit, David Noske, Tom Wurdinger
Publikováno v:
Cancer Research. 82:6312-6312
The current gold-standard of estimating adverse events of a drug are clinical trials. However, these trials fail to represent real-life practice where patients have additional diseases (comorbidities) and commonly use numerous drugs when entering the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::697803d8d9c89679e77d30b98ace248f
https://doi.org/10.1158/1538-7445.am2022-6312
https://doi.org/10.1158/1538-7445.am2022-6312
Autor:
Jantine Geertruida Röttgering, Linda Douw, Philip C. de Witt Hamer, Mathilde C. M. Kouwenhoven, Tom Würdinger, Peter M. van de Ven, Louise Sharpe, Hans Knoop, Martin Klein
Publikováno v:
Trials, Vol 23, Iss 1, Pp 1-10 (2022)
Abstract Background Fatigue is the most frequent and burdensome symptom of patients with diffuse glioma. It is closely linked to decreased health-related quality of life and symptoms such as depression and sleep disturbances. Currently, there is no e
Externí odkaz:
https://doaj.org/article/fb949537545d4a8d98dad2f2cd555020
Autor:
Vera Manders, Allerdien Visser, Remco Keijser, Naomi Min, Ankie Poutsma, Joyce Mulders, Tarah van den Berkmortel, Marjolein Hortensius, Aldo Jongejan, Eva Pajkrt, Erik A. Sistermans, Daoud Sie, Myron G. Best, Tom Würdinger, Marjon de Boer, Gijs Afink, Cees Oudejans
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Abstract Using genome-wide transcriptome analysis by RNA sequencing of first trimester plasma RNA, we tested whether the identification of pregnancies at risk of developing pre-eclampsia with or without preterm birth or growth restriction is possible
Externí odkaz:
https://doaj.org/article/3ef67a8e8858492f80308c0b8c2b1912
Autor:
Rocco Sciarrillo, Anna Wojtuszkiewicz, Btissame El Hassouni, Niccola Funel, Paolo Gandellini, Tonny Lagerweij, Silvia Buonamici, Maxime Blijlevens, Eveline A. Zeeuw van der Laan, Nadia Zaffaroni, Marcello Deraco, Shigeki Kusamura, Tom Würdinger, Godefridus J. Peters, Carla F.M. Molthoff, Gerrit Jansen, Gertjan J.L. Kaspers, Jacqueline Cloos, Elisa Giovannetti
Publikováno v:
EBioMedicine, Vol 39, Iss , Pp 215-225 (2019)
Introduction: Therapeutic options for diffuse malignant peritoneal mesothelioma (DMPM) are limited to surgery and locoregional chemotherapy. Despite improvements in survival rates, patients eventually succumb to disease progression. We investigated s
Externí odkaz:
https://doaj.org/article/db0ee27e25b648199a41ba7a10090d42