Zobrazeno 1 - 10
of 298
pro vyhledávání: '"Tom W. Muir"'
Autor:
Bradley J. Lukasak, Robert E. Thompson, Michelle M. Mitchener, Vanessa J. Feng, John D. Bagert, Tom W. Muir
Publikováno v:
ACS Central Science, Vol 8, Iss 2, Pp 176-183 (2022)
Externí odkaz:
https://doaj.org/article/f58a12d675eb480c86cb6a52d7a60009
Autor:
Christian Albig, Chao Wang, Geoffrey P. Dann, Felix Wojcik, Tamás Schauer, Silke Krause, Sylvain Maenner, Weili Cai, Yeran Li, Jack Girton, Tom W. Muir, Jørgen Johansen, Kristen M. Johansen, Peter B. Becker, Catherine Regnard
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
The chromosomal kinase JIL-1 is responsible for interphase histone H3S10 phosphorylation and has been proposed to protect active chromatin from heterochromatinisation. Here, the authors show that JIL-1 is stabilized and anchored to active genes and t
Externí odkaz:
https://doaj.org/article/cd98c95f8ec34b1b9f4958d116a33d68
Autor:
Siddhant U. Jain, Truman J. Do, Peder J. Lund, Andrew Q. Rashoff, Katharine L. Diehl, Marcin Cieslik, Andrea Bajic, Nikoleta Juretic, Shriya Deshmukh, Sriram Venneti, Tom W. Muir, Benjamin A. Garcia, Nada Jabado, Peter W. Lewis
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
PFA tumours express high levels of EZHIP (also known as CXORF67). Here the authors find that EZHIP directly interacts with the active site of EZH2 and is a competitive inhibitor of PRC2 and that EZHIP gives rise to H3K27me3 genomic profile similar to
Externí odkaz:
https://doaj.org/article/7a64b34bead04eeeabaa7ea08c232938
Autor:
Felix Wojcik, Geoffrey P. Dann, Leslie Y. Beh, Galia T. Debelouchina, Raphael Hofmann, Tom W. Muir
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Ubiquitylation of H2B is associated with transcription and regulation of chromatin structure. Here, the authors perform an unbiased screen to identify the role of chromatin modifications on ubiquitylation of H2BK120 and characterize the crosstalk bet
Externí odkaz:
https://doaj.org/article/0f57f5223d79484f8c00e20c85b246c0
Autor:
Benjamin Y. Winer, Tiffany S. Huang, Eitan Pludwinski, Brigitte Heller, Felix Wojcik, Gabriel E. Lipkowitz, Amit Parekh, Cheul Cho, Anil Shrirao, Tom W. Muir, Eric Novik, Alexander Ploss
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
The lack of models that mimic hepatitis B virus (HBV) infection in a physiologically relevant context has hampered drug development. Here, Winer et al. establish a self-assembling, primary hepatocyte co-culture system that can be infected with patien
Externí odkaz:
https://doaj.org/article/4f4d70c28e204829955bdea52e1122f1
Autor:
Linjiao Zhou, Matthew T. Holt, Nami Ohashi, Aishan Zhao, Manuel M. Müller, Boyuan Wang, Tom W. Muir
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
The ubiquitylation of histone H2B on lysine 120 is an important modification with roles in a diverse range of nuclear processes. Here, the authors use 'designer' chromatin to show that H2B-ub orients hDot1L into the correct position for activation.
Externí odkaz:
https://doaj.org/article/c8971f0fedfb44acb73222b3980cc7bc
Autor:
Ciaran P. Seath, Antony J. Burton, Xuemeng Sun, Gihoon Lee, Ralph E. Kleiner, David W. C. MacMillan, Tom W. Muir
Publikováno v:
Nature. 616:574-580
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88d387877525aaff4a089151a9f069af
https://doi.org/10.1038/s41586-023-05914-y
https://doi.org/10.1038/s41586-023-05914-y
Autor:
Michelle M, Mitchener, Tom W, Muir
Publikováno v:
Molecular Cell. 82:2925-2938
Work over the last decade has uncovered a new layer of epigenetic dysregulation. It is now appreciated that somatic missense mutations in histones, the packaging agents of genomic DNA, are often associated with human pathologies, especially cancer. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::313aed37a5df9e7d6a6f7912f9c6a03f
https://doi.org/10.1016/j.molcel.2022.07.008
https://doi.org/10.1016/j.molcel.2022.07.008
Autor:
Bradley J. Lukasak, Michelle M. Mitchener, Lingchun Kong, Barbara E. Dul, Cole D. Lazarus, Aarthi Ramakrishnan, Jizhi Ni, Li Shen, Ian Maze, Tom W. Muir
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(43)
Recent studies have identified serotonylation of glutamine-5 on histone H3 (H3Q5ser) as a novel posttranslational modification (PTM) associated with active transcription. While H3Q5ser is known to be installed by tissue transglutaminase 2 (TGM2), the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af74c7b331361bfb4f09b9d49926c2bb
https://pubmed.ncbi.nlm.nih.gov/36256821
https://pubmed.ncbi.nlm.nih.gov/36256821
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Studying dynamic biological processes requires approaches compatible with the lifetimes of the biochemical transactions under investigation, which can be very short. We describe a genetically encoded system that allows protein neighborhoods to be map
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16b72b3098baf08dfddbb38fa2f37f98
https://doi.org/10.1073/pnas.2219339120
https://doi.org/10.1073/pnas.2219339120