Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Tom Würdinger"'
Autor:
Jantine Geertruida Röttgering, Linda Douw, Philip C. de Witt Hamer, Mathilde C. M. Kouwenhoven, Tom Würdinger, Peter M. van de Ven, Louise Sharpe, Hans Knoop, Martin Klein
Publikováno v:
Trials, Vol 23, Iss 1, Pp 1-10 (2022)
Abstract Background Fatigue is the most frequent and burdensome symptom of patients with diffuse glioma. It is closely linked to decreased health-related quality of life and symptoms such as depression and sleep disturbances. Currently, there is no e
Externí odkaz:
https://doaj.org/article/fb949537545d4a8d98dad2f2cd555020
Autor:
Vera Manders, Allerdien Visser, Remco Keijser, Naomi Min, Ankie Poutsma, Joyce Mulders, Tarah van den Berkmortel, Marjolein Hortensius, Aldo Jongejan, Eva Pajkrt, Erik A. Sistermans, Daoud Sie, Myron G. Best, Tom Würdinger, Marjon de Boer, Gijs Afink, Cees Oudejans
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Abstract Using genome-wide transcriptome analysis by RNA sequencing of first trimester plasma RNA, we tested whether the identification of pregnancies at risk of developing pre-eclampsia with or without preterm birth or growth restriction is possible
Externí odkaz:
https://doaj.org/article/3ef67a8e8858492f80308c0b8c2b1912
Autor:
Rocco Sciarrillo, Anna Wojtuszkiewicz, Btissame El Hassouni, Niccola Funel, Paolo Gandellini, Tonny Lagerweij, Silvia Buonamici, Maxime Blijlevens, Eveline A. Zeeuw van der Laan, Nadia Zaffaroni, Marcello Deraco, Shigeki Kusamura, Tom Würdinger, Godefridus J. Peters, Carla F.M. Molthoff, Gerrit Jansen, Gertjan J.L. Kaspers, Jacqueline Cloos, Elisa Giovannetti
Publikováno v:
EBioMedicine, Vol 39, Iss , Pp 215-225 (2019)
Introduction: Therapeutic options for diffuse malignant peritoneal mesothelioma (DMPM) are limited to surgery and locoregional chemotherapy. Despite improvements in survival rates, patients eventually succumb to disease progression. We investigated s
Externí odkaz:
https://doaj.org/article/db0ee27e25b648199a41ba7a10090d42
Autor:
Noémie Kraaijpoel, Frits I. Mulder, Marc Carrier, Annabel van Lieshout, Tom Würdinger, Myron G. Best, Bart J.M. van Vlijmen, Yassene Mohammed, Luis Jara-Palomares, Pieter W. Kamphuisen, Marcello Di Nisio, Walter Ageno, Jan Beyer-Westendorf, Thomas Vanassche, Frederikus A. Klokm, Hans-Martin Otten, Mike J.L. Peters, Benilde Cosmi, Marije ten Wolde, Patrick M.M. Bossuyt, Harry R. Büller, Nick van Es
Publikováno v:
Thrombosis Update, Vol 2, Iss , Pp 100030- (2021)
Occult cancer is detected in about 5% of patients with unprovoked venous thromboembolism (VTE) in the 12 months following VTE diagnosis. Current guidance suggests conducting a ‘limited’ cancer screening in these patients, consisting of medical hi
Externí odkaz:
https://doaj.org/article/2dd9496a84fc4b7081e92959d00b7e2f
Autor:
Sophie A. Dusoswa, Sophie K. Horrevorts, Martino Ambrosini, Hakan Kalay, Nanne J. Paauw, Rienk Nieuwland, Michiel D. Pegtel, Tom Würdinger, Yvette Van Kooyk, Juan J. Garcia-Vallejo
Publikováno v:
Journal of Extracellular Vesicles, Vol 8, Iss 1 (2019)
Glioblastoma is the most prevalent and aggressive primary brain tumour for which total tumour lysate-pulsed dendritic cell vaccination is currently under clinical evaluation. Glioblastoma extracellular vesicles (EVs) may represent an enriched cell-fr
Externí odkaz:
https://doaj.org/article/a7fc4dd544604f708191b881d750dd2a
Autor:
Nora Pencheva, Mark C. de Gooijer, Daniel J. Vis, Lodewyk F.A. Wessels, Tom Würdinger, Olaf van Tellingen, René Bernards
Publikováno v:
Cell Reports, Vol 20, Iss 1, Pp 48-60 (2017)
Diffuse and uncontrollable brain invasion is a hallmark of glioblastoma (GBM), but its mechanism is understood poorly. We developed a 3D ex vivo organotypic model to study GBM invasion. We demonstrate that invading GBM cells upregulate a network of e
Externí odkaz:
https://doaj.org/article/92158c78b3084c8292bd15e73c2afcbc
Autor:
Peter Sminia, Jan Theys, Bart A. Westerman, Brigitta G. Baumert, Lukas J.A. Stalpers, Daphne A. Haas-Kogan, Tom Würdinger, Ben J. Slotman, Jaap van den Berg, Rogier Dik, Hou Y.Y.E. Veldman, Tonny Lagerweij, Fleur M.G. Cornelissen, Paul L.G. Slangen, Ana Gasol, Ravi S. Narayan
Supplemental Figure 1. Chemical structures of non-FDA approved compounds used in the Study; Supplemental Figure 2. Effect of drugs on growth and target phosphorylation; Supplemental Figure 3. mTOR inhibition does not show dose dependent Radiosensitiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bc0c910cffbb13d392e1d82fa7f189d
https://doi.org/10.1158/1535-7163.22504666.v1
https://doi.org/10.1158/1535-7163.22504666.v1
Autor:
Peter Sminia, Jan Theys, Bart A. Westerman, Brigitta G. Baumert, Lukas J.A. Stalpers, Daphne A. Haas-Kogan, Tom Würdinger, Ben J. Slotman, Jaap van den Berg, Rogier Dik, Hou Y.Y.E. Veldman, Tonny Lagerweij, Fleur M.G. Cornelissen, Paul L.G. Slangen, Ana Gasol, Ravi S. Narayan
Glioblastoma (GBM) is a highly aggressive and lethal brain cancer type. PI3K and MAPK inhibitors have been studied preclinically in GBM as monotherapy, but not in combination with radiotherapy, which is a key component of the current standard treatme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99956e3c52b0c80f5b93b220beab0d8d
https://doi.org/10.1158/1535-7163.c.6537823.v1
https://doi.org/10.1158/1535-7163.c.6537823.v1
Autor:
Olaf van Tellingen, Tom Würdinger, Jos H. Beijnen, Rolf W. Sparidans, Nishita Thota, Levi C.M. Buil, Gayathri Chandrasekaran, Diana Hanekamp, Mark C. de Gooijer, Fan Lin
File contains information on the methods used to establish murine glioma cell lines and how they have been used to assess the effects of the PI3K inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ec5a997b0f813b3da2f99448140e485
https://doi.org/10.1158/1078-0432.22465941
https://doi.org/10.1158/1078-0432.22465941
Autor:
Olaf van Tellingen, Tom Würdinger, Jos H. Beijnen, Rolf W. Sparidans, Nishita Thota, Levi C.M. Buil, Gayathri Chandrasekaran, Diana Hanekamp, Mark C. de Gooijer, Fan Lin
File contains data on the efficacy of the PI3K inhibitors against murine glioma derived cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfe8b323262281c738068f18fa64f5c9
https://doi.org/10.1158/1078-0432.22465944
https://doi.org/10.1158/1078-0432.22465944