Identifying and exploiting genes that potentiate the evolution of antibiotic resistance

Autor: Antonio Oliver, R. Craig MacLean, Danna R. Gifford, Tom Vogwill, Andrei Papkou, Victoria Furió

Publikováno v: Nature ecology & evolution
Gifford, D R, Furió, V, Papkou, A, Vogwill, T, Oliver, A & MacLean, R C 2018, ' Identifying and exploiting genes that potentiate the evolution of antibiotic resistance ', Nature Ecology and Evolution, vol. 2, no. 6, pp. 1033-1039 . https://doi.org/10.1038/s41559-018-0547-x
Nature Ecology & Evolution

Introductory paragraph There is an urgent need to develop novel approaches for predicting and preventing the evolution of antibiotic resistance. Here we show that the ability to evolve de novo resistance to a clinically important β-lactam antibiotic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16d9aa35db2b0d76d796ae653ad5d92f
https://doi.org/10.1038/s41559-018-0547-x

Epistasis between antibiotic resistance mutations and genetic background shape the fitness effect of resistance across species of Pseudomonas

Autor: Tom Vogwill, R. Maclean, Mila Kojadinovic

Publikováno v: Proceedings of the Royal Society B: Biological Sciences
Proceedings of the Royal Society B: Biological Sciences, Royal Society, The, 2016, ⟨10.1098/rspb.2016.0151.⟩
Proceedings of the Royal Society B: Biological Sciences, 2016, 283(1830), ⟨10.1098/rspb.2016.0151⟩

Antibiotic resistance often evolves by mutations at conserved sites in essential genes, resulting in parallel molecular evolution between divergent bacterial strains and species. Whether these resistance mutations are having parallel effects on fitne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddf85aada8f42ddb3ffb651a673880f7
https://hal-amu.archives-ouvertes.fr/hal-01444160

The experimental evolution of herbicide resistance inChlamydomonas reinhardtiiresults in a positive correlation between fitness in the presence and absence of herbicides

Autor: Paul Neve, Tom Vogwill, Nick Colegrave, Mato Lagator

Publikováno v: Journal of Evolutionary Biology. 25:1955-1964

Pleiotropic fitness trade-offs will be key determinants of the evolutionary dynamics of selection for pesticide resistance. However, for herbicide resistance, empirical support for a fitness cost of resistance is mixed, and it is therefore also quest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d19f397a3dbaf775958ecd0f24e1f4ae
https://doi.org/10.1111/j.1420-9101.2012.02558.x

HOW DOES SPATIAL DISPERSAL NETWORK AFFECT THE EVOLUTION OF PARASITE LOCAL ADAPTATION?

Autor: Michael A. Brockhurst, Tom Vogwill, Andy Fenton

Publikováno v: Evolution. 64:1795-1801

Studying patterns of parasite local adaptation can provide insights into the spatiotemporal dynamics of host-parasite coevolution. Many factors, both biotic and abiotic, have been identified that influence parasite local adaptation. In particular, di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::73aa8a174efac21974a8a4c6f8fe23fd
https://doi.org/10.1111/j.1558-5646.2009.00937.x

Limits to compensatory adaptation and the persistence of antibiotic resistance in pathogenic bacteria

Autor: R. Craig MacLean, Tom Vogwill

Publikováno v: Evolution, Medicine, and Public Health

Antibiotic resistance carries a fitness cost that could potentially limit the spread of resistance in bacterial pathogens. In spite of this cost, a large number of experimental evolution studies have found that resistance is stably maintained in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0740e007d0f28146249152ccc699c994
https://pubmed.ncbi.nlm.nih.gov/25535278