Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Tom Van Belle"'
Publikováno v:
Journal of Autoimmunity. 40:66-73
It is thought that viral infections might jeopardize regulatory T cell therapy in type 1 diabetes. Viral infections can lead to surface expression of ligands for the activating NKG2D receptor, such as retinoic acid early transcript 1 (Rae-1), whose e
Publikováno v:
Pediatric Diabetes. 14:81-89
Vitamin D is a fat-soluble precursor of the circulating 25-hydroxyvitamin D₃ (25(OH)D₃)which can be converted by the 1α-hydroxylase (1α(OH)ase) enzyme into the bioactive hormonal metabolite 1,25-dihydroxyvitamin D₃ (1,25(OH)₂D₃), generall
Autor:
Enric Esplugues, Therese Juntti, Matthias von Herrath, Tom Van Belle, Richard A. Flavell, Jeanette Liao
Publikováno v:
The Journal of Immunology
Recent studies have shown that IL-17 can contribute beneficially to pathogen defense but also that excessive IL-17 levels are associated with chronic inflammation and autoimmune disorders. To date, the role of IL-17 in viral infections and type 1 dia
Publikováno v:
Physiological Reviews. 91:79-118
Type 1 diabetes (T1D) is a chronic autoimmune disease in which destruction or damaging of the beta-cells in the islets of Langerhans results in insulin deficiency and hyperglycemia. We only know for sure that autoimmunity is the predominant effector
Publikováno v:
Journal of Autoimmunity. 34:445-452
Redirection of immune responses by manipulation of antigen-presenting cells is an emerging strategy for immunosuppressive treatment of autoimmune diseases. In vivo expansion of dendritic cells (DC) by Fms-like tyrosine kinase-3 (Flt3)-Ligand (FL) tre
Autor:
Michael J. Grusby, Andrea L. Wurster, Tom Van Belle, Andrew P. R. Sutherland, Monia Michaud, Dorothy Zhang, Matthias von Herrath, Akira Suto
Publikováno v:
Diabetes
OBJECTIVE Interleukin (IL)-21 is a type 1 cytokine that has been implicated in the pathogenesis of type 1 diabetes via the unique biology of the nonobese diabetic (NOD) mouse strain. The aim of this study was to investigate a causal role for IL-21 in
Autor:
Gwenda Pynaert, Johan Grooten, Pieter Rottiers, Tom Van Belle, Anuschka Haegeman, Sarita Sehra, Johanna E. Korf
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 29:634-641
Local inflammatory responses involve relocating immune functions generated by previous immunization to confined parts of the body, and hence are presumed to reflect the prevailing systemic immune bias. To verify to what extent local antigen-presentin
Autor:
Gabriela B Ferreira, Jocelyne Demengeot, Chantal Mathieu, Tom Van Belle, Hannelie Korf, An-Sofie Vanherwegen, Annemieke Verstuyf, João Paulo Monteiro Carvalho Mori da Cunha, Lut Overbergh, F Pauwels, Conny Gysemans
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
This deposit is composed by a publication in which the IGC's authors have had the role of collaboration (it's a collaboration publication). This type of deposit in ARCA is in restrictedAccess (it can't be in open access to the public), and can only b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b29b5015af02a108baac0a31e9cf5a6
Autor:
Chantal Mathieu, An-Sofie Vanherwegen, Pierre J. De Clercq, Annemieke Verstuyf, Hannelie Korf, Tom Van Belle, Conny Gysemans, Dorien Feyaerts
Publikováno v:
PLOS ONE
PLoS ONE
PLoS ONE, Vol 9, Iss 10, p e109194 (2014)
PLoS ONE
PLoS ONE, Vol 9, Iss 10, p e109194 (2014)
The emergence of regulatory T cells (Tregs) as central mediators of peripheral tolerance in the immune system has led to an important area of clinical investigation to target these cells for the treatment of autoimmune diseases such as type 1 diabete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a843b5c9eb23a89166c42e21be0f8cb4
https://lirias.kuleuven.be/handle/123456789/468973
https://lirias.kuleuven.be/handle/123456789/468973
Publikováno v:
Scopus-Elsevier
Clonal deletion and anergy are 2 mechanisms used by the immune system to establish peripheral tolerance. In vitro, these mechanisms are induced in T lymphocytes by triggering the T-cell receptor (signal 1) in the absence of costimulation (signal 2).