Collagen IV deficiency causes hypertrophic remodeling and endothelium-dependent hyperpolarization in small vessel disease with intracerebral hemorrhageResearch in context

Autor: Sarah McNeilly, Cameron R. Thomson, Laura Gonzalez-Trueba, Yuan Yan Sin, Alessandra Granata, Graham Hamilton, Michelle Lee, Erin Boland, John D. McClure, Cristina Lumbreras-Perales, Alisha Aman, Apoorva A. Kumar, Marco Cantini, Caglar Gök, Delyth Graham, Yasuko Tomono, Christopher D. Anderson, Yinhui Lu, Colin Smith, Hugh S. Markus, Marc Abramowicz, Catheline Vilain, Rustam Al-Shahi Salman, Manuel Salmeron-Sanchez, Atticus H. Hainsworth, William Fuller, Karl E. Kadler, Neil J. Bulleid, Tom Van Agtmael

Publikováno v: EBioMedicine, Vol 107, Iss , Pp 105315- (2024)

Summary: Background: Genetic variants in COL4A1 and COL4A2 (encoding collagen IV alpha chain 1/2) occur in genetic and sporadic forms of cerebral small vessel disease (CSVD), a leading cause of stroke, dementia and intracerebral haemorrhage (ICH). Ho

Externí odkaz: https://doaj.org/article/d38bd2e3219f479e9d1e302cbcbad3f9

Four decades in the making: Collagen III and mechanisms of vascular Ehlers Danlos Syndrome

Autor: Ramla Omar, Fransiska Malfait, Tom Van Agtmael

Publikováno v: Matrix Biology Plus, Vol 12, Iss , Pp 100090- (2021)

Vascular Ehlers Danlos (vEDS) syndrome is a severe multi-systemic connective tissue disorder characterized by risk of dissection and rupture of the arteries, gastro-intestinal tract and gravid uterus. vEDS is caused by mutations in COL3A1, that encod

Externí odkaz: https://doaj.org/article/452f1caa58e84d28885d5a7c4703abde

The Chemical Chaperone, PBA, Reduces ER Stress and Autophagy and Increases Collagen IV α5 Expression in Cultured Fibroblasts From Men With X-Linked Alport Syndrome and Missense Mutations

Autor: Dongmao Wang, Mardhiah Mohammad, Yanyan Wang, Rachel Tan, Lydia S. Murray, Sharon Ricardo, Hayat Dagher, Tom van Agtmael, Judy Savige

Publikováno v: Kidney International Reports, Vol 2, Iss 4, Pp 739-748 (2017)

X-linked Alport syndrome (OMIM 301050) is caused by COL4A5 missense variants in 40% of families. This study examined the effects of chemical chaperone treatment (sodium 4-phenylbutyrate) on fibroblast cell lines derived from men with missense mutatio

Externí odkaz: https://doaj.org/article/5724dcfdc6084cc9a635daba935ae26d

Tendon is covered by a basement membrane epithelium that is required for cell retention and the prevention of adhesion formation.

Autor: Susan H Taylor, Sarah Al-Youha, Tom Van Agtmael, Yinhui Lu, Jason Wong, Duncan A McGrouther, Karl E Kadler

Publikováno v: PLoS ONE, Vol 6, Iss 1, p e16337 (2011)

The ability of tendons to glide smoothly during muscle contraction is impaired after injury by fibrous adhesions that form between the damaged tendon surface and surrounding tissues. To understand how adhesions form we incubated excised tendons in fi

Externí odkaz: https://doaj.org/article/e929614ef72b4677b4023ee8a18b7f85

Basement membrane stiffness determines metastases formation

Autor: Anu Laitala, Sarah McNeilly, Sina Zendehroud, Lene B. Oddershede, Maria Rafaeva, Wilhelm Bloch, Monica Nicolau, Stefanie Sudhop, Stefanie Kiderlen, Janine T. Erler, Alejandro E Mayorca-Guiliani, Frank Suhr, Carina Prein, Lutz Fleischhauer, Kamilla Westarp Zornhagen, Benjamin Furtwängler, Chris D. Madsen, Denise Nikodemus, Tom Van Agtmael, Kyoung-Jae Won, Hyobin Kim, Erwin M. Schoof, Manuel Koch, Eleni Maniati, Hauke Clausen-Schaumann, Oliver M. T. Pearce, Sebastian R. Nielsen, Lena Wullkopf, Roland R. Netz, Bo T. Porse, Raphael Reuten

Publikováno v: Reuten, R, Zendehroud, S, Nicolau, M, Fleischhauer, L, Laitala, A, Kiderlen, S, Nikodemus, D, Wullkopf, L, Nielsen, S R, McNeilly, S, Prein, C, Rafaeva, M, Schoof, E M, Furtwängler, B, Porse, B T, Kim, H, Won, K J, Sudhop, S, Zornhagen, K W, Suhr, F, Maniati, E, Pearce, O M T, Koch, M, Oddershede, L B, Van Agtmael, T, Madsen, C D, Mayorca-Guiliani, A E, Bloch, W, Netz, R R, Clausen-Schaumann, H & Erler, J T 2021, ' Basement membrane stiffness determines metastases formation ', Nature Materials, vol. 20, pp. 892-903 . https://doi.org/10.1038/s41563-020-00894-0
Nature Materials
Reuten, R, Zendehroud, S, Nicolau, M, Fleischhauer, L, Laitala, A, Kiderlen, S, Nikodemus, D, Wullkopf, L, Nielsen, S R, Mcneilly, S, Prein, C, Rafaeva, M, Schoof, E M, Furtwängler, B, Porse, B T, Kim, H, Won, K J, Sudhop, S, Zornhagen, K W, Suhr, F, Maniati, E, Pearce, O M T, Koch, M, Oddershede, L B, Van Agtmael, T, Madsen, C D, Mayorca-guiliani, A E, Bloch, W, Netz, R R, Clausen-schaumann, H & Erler, J T 2021, ' Basement membrane stiffness determines metastases formation ', Nature Materials, vol. 20, pp. 892–903 . https://doi.org/10.1038/s41563-020-00894-0

The basement membrane (BM) is a special type of extracellular matrix and presents the major barrier cancer cells have to overcome multiple times to form metastases. Here we show that BM stiffness is a major determinant of metastases formation in seve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96f427761cf55f30e15fcec94a085b37
https://doi.org/10.1038/s41563-020-00894-0