Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Tom T Fischer"'
Autor:
Ryan Y. Nguyen, Hugh Xiao, Xiangyu Gong, Alfredo Arroyo, Aidan T. Cabral, Tom T. Fischer, Kaitlin M. Flores, Xuchen Zhang, Marie E. Robert, Barbara E. Ehrlich, Michael Mak
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-17 (2022)
Treatment for liver cancer is complicated by its various subtypes, which show different responses to anticancer drugs. This study demonstrates the effectiveness of targeting biophysical phenotypes related to cytoskeleton properties that are usually m
Externí odkaz:
https://doaj.org/article/61f6dcee595e4f84a582f13e316a2289
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-16 (2021)
Abstract Background After chemotherapy, many cancer survivors suffer from long-lasting cognitive impairment, colloquially known as “chemobrain.” However, the trajectories of cognitive changes and the underlying mechanisms remain unclear. We previ
Externí odkaz:
https://doaj.org/article/5625476c5c6e44dfbbb57f40d1aed73e
Publikováno v:
Molecular Oncology, Vol 14, Iss 6, Pp 1134-1151 (2020)
Changes in intracellular calcium (Ca2+) signaling can modulate cellular machinery required for cancer progression. Neuronal calcium sensor 1 (NCS1) is a ubiquitously expressed Ca2+‐binding protein that promotes tumor aggressiveness by enhancing cel
Externí odkaz:
https://doaj.org/article/720596b58db84d30b843d6598f2e2451
Autor:
Tom T Fischer, Kendra K Maaß, Pitithat Puranachot, Agnes M E Finster, Markus Mieskolainen, Paulina S Schad, Martin Sill, Fabian Rosing, Tatjana Wedig, Nathalie Schwarz, Florian Iser, Jochen Meyer, Felix Sahm, Benedikt Brors, Hannu Haapasalo, Stefan M Pfister, Joonas Haapasalo, Kristian W Pajtler, Kristiina Nordfors
Publikováno v:
Neuro-Oncology. 24:i160-i161
BACKGROUND: Liquid biopsies (LBs) hold great promise as a non-invasive method for tumor detection and disease monitoring. Their application in pediatric neuro-oncology patients has been challenging due to the blood-brain barrier limiting the amount o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::080056f87231c7ca1e925f33675b406d
https://doi.org/10.1093/neuonc/noac079.595
https://doi.org/10.1093/neuonc/noac079.595
Publikováno v:
FASEB J
Calcium (Ca2+) signaling is critical for neuronal functioning and requires the concerted interplay of numerous Ca2+-binding proteins, including neuronal calcium sensor 1 (NCS1). Although an important role of NCS1 in neuronal processes and in neurodev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df7eee4b4117f9c6868d71f312941890
https://europepmc.org/articles/PMC8462996/
https://europepmc.org/articles/PMC8462996/
Autor:
Ryan Y, Nguyen, Hugh, Xiao, Xiangyu, Gong, Alfredo, Arroyo, Aidan T, Cabral, Tom T, Fischer, Kaitlin M, Flores, Xuchen, Zhang, Marie E, Robert, Barbara E, Ehrlich, Michael, Mak
Publikováno v:
Communications biology. 5(1)
Drug treatment against liver cancer has limited efficacy due to heterogeneous response among liver cancer subtypes. In addition, the functional biophysical phenotypes which arise from this heterogeneity and contribute to aggressive invasive behavior
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7718504fcf3930441e1276f4ffc1ac4e
https://pubmed.ncbi.nlm.nih.gov/35241781
https://pubmed.ncbi.nlm.nih.gov/35241781
Autor:
Marie E. Robert, Stuart G. Campbell, Allison L. Brill, Parker C. Wilson, Arnaud Marlier, Gilbert W. Moeckel, Tom T. Fischer, Hee Jung Chung, Jeanne M. Nerbonne, Barbara E. Ehrlich, Eric K. Johnson, Lorenzo R. Sewanan, Jennifer M. Walters, Lloyd G. Cantley
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports
Polycystin 2 (PC2 or TRPP1, formerly TRPP2) is a calcium-permeant Transient Receptor Potential (TRP) cation channel expressed primarily on the endoplasmic reticulum (ER) membrane and primary cilia of all cell and tissue types. Despite its ubiquitous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b747ce23c14f22338c67c7d8c189d82c
http://link.springer.com/article/10.1038/s41598-019-57286-x
http://link.springer.com/article/10.1038/s41598-019-57286-x
Publikováno v:
Cell Calcium. 104:102572
Wolfram syndrome is a rare genetic disorder characterized by endocrine dysfunction and progressive neurodegeneration. By targeting intracellular calcium dysregulations, a sigma-1 receptor agonist rescued neurological deficits in preclinical models of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faa1ca18c422352a516a8ca9814d3916
https://doi.org/10.1016/j.ceca.2022.102572
https://doi.org/10.1016/j.ceca.2022.102572
Autor:
Barbara E. Ehrlich, Tom T. Fischer
Publikováno v:
Curr Opin Physiol
Wolfram syndrome (WS) is a rare, progressive disorder characterized by childhood-onset diabetes mellitus, optic nerve atrophy, hearing loss, diabetes insipidus, and neurodegeneration. Currently, there is no effective treatment for WS, and patients ty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7f03d54bf17dbf126f82375968b4236
https://europepmc.org/articles/PMC7451204/
https://europepmc.org/articles/PMC7451204/
Publikováno v:
Molecular Neurodegeneration
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-16 (2021)
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-16 (2021)
Background After chemotherapy, many cancer survivors suffer from long-lasting cognitive impairment, colloquially known as “chemobrain.” However, the trajectories of cognitive changes and the underlying mechanisms remain unclear. We previously est
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a641897aa4864b68d0f08f1550e15af
https://pubmed.ncbi.nlm.nih.gov/34174909
https://pubmed.ncbi.nlm.nih.gov/34174909