Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Tom T Caradoc-Davies"'
Autor:
Natalya Lukoyanova, Stephanie C Kondos, Irene Farabella, Ruby H P Law, Cyril F Reboul, Tom T Caradoc-Davies, Bradley A Spicer, Oded Kleifeld, Daouda A K Traore, Susan M Ekkel, Ilia Voskoboinik, Joseph A Trapani, Tamas Hatfaludi, Katherine Oliver, Eileen M Hotze, Rodney K Tweten, James C Whisstock, Maya Topf, Helen R Saibil, Michelle A Dunstone
Publikováno v:
PLoS Biology, Vol 13, Iss 2, p e1002049 (2015)
Membrane attack complex/perforin-like (MACPF) proteins comprise the largest superfamily of pore-forming proteins, playing crucial roles in immunity and pathogenesis. Soluble monomers assemble into large transmembrane pores via conformational transiti
Externí odkaz:
https://doaj.org/article/61da81d52f214c008c291f4ba889cd9a
Autor:
Adam J. Quek, Nathan P. Cowieson, Tom T. Caradoc-Davies, Paul J. Conroy, James C. Whisstock, Ruby H. P. Law
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 18, p 14258 (2023)
Plasminogen (Plg) is the inactive form of plasmin (Plm) that exists in two major glycoforms, referred to as glycoforms I and II (GI and GII). In the circulation, Plg assumes an activation-resistant “closed” conformation via interdomain interactio
Externí odkaz:
https://doaj.org/article/0e25f129ee1a4bb79ced86f7bdf462b2
Autor:
Ruby H.P. Law, Guojie Wu, Eleanor W.W. Leung, Koushi Hidaka, Adam J. Quek, Tom T. Caradoc-Davies, Devadharshini Jeevarajah, Paul J. Conroy, Nigel M. Kirby, Raymond S. Norton, Yuko Tsuda, James C. Whisstock
Publikováno v:
Blood Advances, Vol 1, Iss 12, Pp 766-771 (2017)
Abstract: The zymogen protease plasminogen and its active form plasmin perform key roles in blood clot dissolution, tissue remodeling, cell migration, and bacterial pathogenesis. Dysregulation of the plasminogen/plasmin system results in life-threate
Externí odkaz:
https://doaj.org/article/b3a0c868cfc44aa795c55be0ba7c2b58
Autor:
Daniel J. Ericsson, Tom T. Caradoc-Davies, Alan Riboldi-Tunnicliffe, Jun Aishima, Kate Smith, Rachel M. Williamson, Santosh Panjikar, Nathan Cowieson, Jason R. Price, Christine L. Gee, Stephen J. Harrop, David Aragão, Stuart J. Mills
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 76, Iss 7, Pp 1136-1138 (2020)
Acta Crystallographica Section E: Crystallographic Communications
Acta Crystallographica Section E: Crystallographic Communications
Exceptionally large crystals of posnjakite, Cu4SO4(OH)6(H2O), formed during corrosion of a Swagelock(tm) Snubber copper gasket within the MX1 beamline at the ANSTO-Melbourne, Australian Synchrotron. The crystal structure was solved using synchrotron
Autor:
James C. Whisstock, Guojie Wu, Ruby H. P. Law, Adam J. Quek, Blake A. Mazzitelli, Tom T. Caradoc-Davies, Sue M. Ekkel
Publikováno v:
Biochemical Society Transactions. 47:541-557
Plasminogen (Plg) is the zymogen form of the serine protease plasmin (Plm), and it plays a crucial role in fibrinolysis as well as wound healing, immunity, tissue remodeling and inflammation. Binding to the targets via the lysine-binding sites allows
Autor:
Joakim E. Swedberg, David J. Craik, Ruby H. P. Law, Thomas Durek, Tunjung Mahatmanto, Tom T. Caradoc-Davies, Guojie Wu, James C. Whisstock
Publikováno v:
Journal of Medicinal Chemistry. 62:552-560
Antifibrinolytic drugs provide important pharmacological interventions to reduce morbidity and mortality from excessive bleeding during surgery and after trauma. Current drugs used for inhibiting the dissolution of fibrin, the main structural compone
Autor:
Maiada M. Sadek, Nicholas Barlow, Eleanor W. W. Leung, Billy J. Williams-Noonan, Beow Keat Yap, Fairolniza Mohd Shariff, Tom T. Caradoc-Davies, Sandra E. Nicholson, David K. Chalmers, Philip E. Thompson, Ruby H. P. Law, Raymond S. Norton
Publikováno v:
ACS Chemical Biology. 13:2930-2938
SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4 interact with inducible nitric oxide synthase (iNOS), causing the iNOS to be polyubiquitinated and targeted for degradation. Inhibition of this interaction increases iNOS levels, a
Autor:
Tom T. Caradoc-Davies, Jun Aishima, Nathan Mudie, Santosh Panjikar, Nathan Cowieson, Alan Riboldi-Tunnicliffe, Daniel J. Ericsson, Mark Clift, S. Macedo, Christine L. Gee, Robert Rostan, David Aragão, Robert Clarken, Hima Cherukuvada, Rachel M. Williamson, Jason R. Price
Publikováno v:
Journal of Synchrotron Radiation
A microfocus macromolecular crystallography beamline at the Australian Synchrotron is presented.
MX2 is an in-vacuum undulator-based crystallography beamline at the 3 GeV Australian Synchrotron. The beamline delivers hard X-rays in the energy ra
MX2 is an in-vacuum undulator-based crystallography beamline at the 3 GeV Australian Synchrotron. The beamline delivers hard X-rays in the energy ra
Autor:
James C. Whisstock, Tom T. Caradoc-Davies, Yuko Tsuda, Koushi Hidaka, Raymond S. Norton, Paul J. Conroy, Eleanor W. W. Leung, Guojie Wu, Nigel Kirby, Adam J. Quek, Ruby H. P. Law, Devadharshini Jeevarajah
Publikováno v:
Blood Advances. 1:766-771
The zymogen protease plasminogen and its active form plasmin perform key roles in blood clot dissolution, tissue remodeling, cell migration, and bacterial pathogenesis. Dysregulation of the plasminogen/plasmin system results in life-threatening hemor
Autor:
Yue Yuan, Martina L. Sanderson-Smith, Adam J. Quek, Devadharshini Jeevarajah, James C. Whisstock, Ruby H. P. Law, Paul J. Conroy, Yetunde A. Ayinuola, Guojie Wu, Blake A. Mazzitelli, Eleanor W. W. Leung, Gordon J. Lloyd, Francis J. Castellino, Tom T. Caradoc-Davies
Publikováno v:
J Mol Biol
Plasminogen (Plg)-binding M protein (PAM) is a group A streptococcal cell surface receptor that is crucial for bacterial virulence. Previous studies revealed that, by binding to the kringle 2 (KR2) domain of host Plg, the pathogen attains a proteolyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f00dd06202e8856abecac9f7d325e8c
https://europepmc.org/articles/PMC7722781/
https://europepmc.org/articles/PMC7722781/