Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Tom Suter"'
Publikováno v:
Trends in genetics : TIG. 38(10)
Gene regulation by transcriptional enhancers is the dominant mechanism driving cell type- and signal-specific transcriptional diversity in metazoans. However, over four decades since the original discovery, how enhancers operate in the nuclear space
Autor:
Qi Ma, Kenneth A. Ohgi, Tom Suter, Soohwan Oh, Priya R. Banerjee, Lu Yang, Jie Zhang, Meyer J. Friedman, Amir Gamliel, Yiren Hu, Aneel K. Aggarwal, Feng Yang, Dario Meluzzi, Susan Wang, Ranveer Singh Jayani, Yuliang Tan, Ibraheem Alshareedah, Sreejith J Nair, Michael G. Rosenfeld
Publikováno v:
Nature structural & molecular biology, vol 26, iss 3
A crucial feature of differentiated cells is the rapid activation of enhancer-driven transcriptional programs in response to signals. The potential contributions of physicochemical properties of enhancer assembly in signaling events remain poorly und
Autor:
Wubin Ma, Tom Suter, Michael G. Rosenfeld, Yuliang Tan, Kenneth A. Ohgi, Eugin Destici, Daria Merkurjev, Dorota Skowronska-Krawczyk, Hong Sook Kim, Qi Ma, Meyer J. Friedman
Publikováno v:
Nature, vol 556, iss 7702
Enhancers for embryonic stem (ES) cell-expressed genes and lineage-determining factors are characterized by conventional marks of enhancer activation in ES cells1-3, but it remains unclear whether enhancers destined to regulate cell-type-restricted t
Autor:
Wenbo Li, Jie Zhang, Piotr Kozbial, Kenneth A. Ohgi, Yuliang Tan, Janusz Puc, Zhijie Liu, Aneel K. Aggarwal, Tom Suter, Michael G. Rosenfeld
Publikováno v:
Cell, vol 160, iss 3
SummaryThe discovery that enhancers are regulated transcription units, encoding eRNAs, has raised new questions about the mechanisms of their activation. Here, we report an unexpected molecular mechanism that underlies ligand-dependent enhancer activ
Periodical
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