CCL24 regulates biliary inflammation and fibrosis in primary sclerosing cholangitis

Autor: Raanan Greenman, Michal Segal-Salto, Neta Barashi, Ophir Hay, Avi Katav, Omer Levi, Ilan Vaknin, Revital Aricha, Sarit Aharoni, Tom Snir, Inbal Mishalian, Devorah Olam, Johnny Amer, Ahmad Salhab, Rifaat Safadi, Yaakov Maor, Palak Trivedi, Christopher J. Weston, Francesca Saffioti, Andrew Hall, Massimo Pinzani, Douglas Thorburn, Amnon Peled, Adi Mor

Publikováno v: JCI Insight, Vol 8, Iss 12 (2023)

ˆCCL24 is a pro-fibrotic, pro-inflammatory chemokine expressed in several chronic fibrotic diseases. In the liver, CCL24 plays a role in fibrosis and inflammation, and blocking CCL24 led to reduced liver injury in experimental models. We studied the

Externí odkaz: https://doaj.org/article/db72715b10e74e2cbaca199c73a4f4ca

A T cell repertoire timestamp is at the core of responsiveness to CTLA-4 blockade

Autor: Hagit Philip, Tom Snir, Miri Gordin, Mikhail Shugay, Alona Zilberberg, Sol Efroni

Publikováno v: iScience, Vol 24, Iss 2, Pp 102100- (2021)

Summary: Biology of the response to anti-CTLA-4 involves the dynamics of specific T cell clones. Reasons for clinical success and failure of this treatment are still largely unknown. Here, we quantified the dynamics of the T cell receptor (TCR) reper

Externí odkaz: https://doaj.org/article/d9b2b6c4f42f422c863a290ec605f966

Age-related loss of gene-to-gene transcriptional coordination among single cells

Autor: Orr Levy, Yang-Yu Liu, Peter J. Castaldi, Haim Y. Cohen, Amir Bashan, Guy Amit, Sol Efroni, Dana Vaknin, Tom Snir

Publikováno v: Nature Metabolism. 2:1305-1315

A long-standing model holds that stochastic aberrations of transcriptional regulation play a key role in the process of ageing. While transcriptional dysregulation is observed in many cell types in the form of increased cell-to-cell variability, its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f15c2f2de12d0e7270818176c38ed05
https://doi.org/10.1038/s42255-020-00304-4

Gene selection for optimal prediction of cell position in tissues from single-cell transcriptomics data

Autor: Jovan, Tanevski, Thin, Nguyen, Buu, Truong, Nikos, Karaiskos, Mehmet Eren Ahsen, Xinyu, Zhang, Chang, Shu, Ke, Xu, Xiaoyu, Liang, Ying, Hu, Hoang VV Pham, Xiaomei, Li, Thuc, D Le, Adi, L Tarca, Gaurav, Bhatti, Roberto, Romero, Nestoras, Karathanasis, Phillipe, Loher, Yang, Chen, Zhengqing, Ouyang, Disheng, Mao, Yuping, Zhang, Maryam, Zand, Jianhua, Ruan, Christoph, Hafemeister, Peng, Qiu, Duc, Tran, Tin, Nguyen, Attila, Gabor, Thomas, Yu, Justin, Guinney, Enrico, Glaab, Roland, Krause, Peter, Banda, DREAM SCTC Consortium, Baruzzo, Giacomo, Cappellato, Marco, Zorzan, Irene, DEL FAVERO, Simone, Schenato, Luca, Vandin, Fabio, DI CAMILLO, Barbara, Shruti, Gupta, Ajay Kumar Verma, Shandar, Ahmad, Ronesh, Sharma, Edwin, Vans, Alok, Sharma, Ashwini, Patil, Alejandra, Carrea, Alonso, Andres M., Luis, Diambra, Vijay, Narsapuram, Vinay, Kaikala, Chaitanyam, Potnuru, Sunil, Kumar, Jiajie, Peng, Xiaoyu, Wang, Xuequn, Shang, Dani, Livne, Tom, Snir, Hagit, Philip, Alona, Zilberberg, Sol, Efroni, Hamid Reza Hassanzadeh, Reihaneh, Hassanzadeh, Ghazal, Jahanshahi, M-Mahdi, Naddaf-Sh, Drayer, Phillip M., Sadra, Naddaf-Sh, Marouen Ben Guebila, Changlin, Wan, Yuchen, Cao, Saber, Meamardoost, Nan Papili Gao, Rudiyanto, Gunawan, Gustavo, Stolovitzky, Nikolaus, Rajewsky, Julio, Saez-Rodriguez, Pablo, Meyer

Publikováno v: Life Science Alliance

We describe and provide an array of diverse methods to predict cellular positions in tissue from RNA-seq data selecting mapping genes according to their spatial/statistical properties and their effect on improving the cell positioning.
Single-ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24f19c28fbdbe4c77371a58fd92e3a3b
http://edoc.mdc-berlin.de/19409/1/19409oa.pdf