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Publikováno v:
Annals of the New York Academy of Sciences. 772:271-273
Publikováno v:
Biochemical Pharmacology. 38:1657-1665
Diazepam (DZ) was used as a substrate in drug metabolism studies to characterise the differences in metabolite profiles in hepatocytes isolated from four species: Wistar rat, cynomolgus monkey, beagle dog and man. Hepatocytes were incubated with DZ (
Publikováno v:
Biochemical pharmacology. 38(16)
Diazepam (DZ), N-desmethyl diazepam (NOR) and temazepam (TEM) were used as substrates in drug metabolism studies to characterize the changes in cytochrome P-450 mono-oxygenase pathways in hepatocytes isolated from cynomolgus monkeys, during culture f