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pro vyhledávání: '"Tom Ronan"'
Publikováno v:
J Biol Chem
Protein domain interactions with short linear peptides, such as Src homology 2 (SH2) domain interactions with phosphotyrosine-containing peptide motifs (pTyr), are ubiquitous and important to many biochemical processes of the cell. The desire to map
Autor:
Linda J. Pike, Jennifer L. Macdonald-Obermann, Tom Ronan, Nicholas J. Bessman, Lorel Huelsmann, Kristen M. Naegle
Publikováno v:
Journal of Biological Chemistry. 291:5528-5540
The EGF receptor can bind seven different agonist ligands. Although each agonist appears to stimulate the same suite of downstream signaling proteins, different agonists are capable of inducing distinct responses in the same cell. To determine the ba
Publikováno v:
Science Signaling. 9
Clustering is an unsupervised learning method, which groups data points based on similarity, and is used to reveal the underlying structure of data. This computational approach is essential to understanding and visualizing the complex data that are a
Autor:
Tom Ronan1, Macdonald-Obermann, Jennifer L.2, Huelsmann, Lorel2, Bessman, Nicholas J.3, Naegle, Kristen M.1 knaegle@wustl.edu, Pike, Linda J.2 pike@biochem.wustl.edu
Publikováno v:
Journal of Biological Chemistry. 3/1/2016, Vol. 291 Issue 10, p5528-5540. 20p.
Publikováno v:
Cellular and Molecular Life Sciences
T-box transcription factors are critical developmental regulators in all multi-cellular organisms, and altered T-box factor activity is associated with a variety of human congenital diseases and cancers. Despite the biological significance of T-box f