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of 4
pro vyhledávání: '"Tom R. Norton"'
Publikováno v:
Carcinogenesis. 13:107-112
Rat liver N-hydroxy-2-acetylaminofluorene (N-OH-2AAF) sulfotransferase activity is mediated by aryl sulfotransferase IV (AST IV) and causes the bioactivation of N-OH-2AAF to a highly reactive sulfuric acid ester form putatively capable of inducing li
Autor:
Tom R. Norton, Boyd A. Howell, Gary W. Woulfe, Michael W. Duffel, David P. Ringer, Stanley D. Kosanke
Publikováno v:
Molecular carcinogenesis. 9(1)
Enzymatic and immunohistochemical experiments were conducted to evaluate the mechanistic basis for the downregulation of the important detoxication/bioactivation enzyme aryl sulfotransferase IV (AST IV) during 2-acetylaminofluorene (2AAF)-induced hep
Publikováno v:
Biochemical Pharmacology. 34:3380-3383
Autor:
Tom R. Norton, David P. Ringer
Publikováno v:
Carcinogenesis. 8(11)
Aryl sulfotransferase (AST) activity in rat liver is thought to be a primary pathway in the bio-activation of various hepatocarcinogens to forms which act as ultimate carcinogens in chemical hepatocarcinogenesis. In an effort to understand the signif