Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Tom R, Webb"'
Autor:
David G. McVey, Catherine Andreadi, Peng Gong, Paulina J. Stanczyk, Charles U. Solomon, Lenka Turner, Liu Yan, Runji Chen, Junjun Cao, Christopher P. Nelson, John R. Thompson, Haojie Yu, Tom R. Webb, Nilesh J. Samani, Shu Ye
Publikováno v:
Cell Death and Disease, Vol 15, Iss 6, Pp 1-12 (2024)
Abstract Vascular smooth muscle cell (VSMC) proliferation, migration, and apoptosis play important roles in many physiological processes and pathological conditions. To identify genetic influences on VSMC behavior, we measured these traits and undert
Externí odkaz:
https://doaj.org/article/dda64775ac3d45af905d844b31b95902
Autor:
Radoslaw Debiec, Stephen E. Hamby, Peter D. Jones, Sue Coolman, Manish Asiani, Shireen Kharodia, Gregory J. Skinner, Nilesh J. Samani, Tom R. Webb, Aidan Bolger
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 8, Iss 10, Pp n/a-n/a (2020)
Abstract Background Bicuspid aortic valve is the most common congenital valvular heart defect in the general population. BAV is associated with significant morbidity due to valve failure, formation of thoracic aortic aneurysm, and increased risk of i
Externí odkaz:
https://doaj.org/article/ac256f24ae524577b9101b1f61cb77f7
Autor:
Elisavet Karamanavi, David G. McVey, Sander W. van der Laan, Paulina J. Stanczyk, Gavin E. Morris, Yifan Wang, Wei Yang, Kenneth Chan, Robin N. Poston, Jun Luo, Xinmiao Zhou, Peng Gong, Peter D. Jones, Junjun Cao, Renata B. Kostogrys, Tom R. Webb, Gerard Pasterkamp, Haojie Yu, Qingzhong Xiao, Peter A. Greer, Emma J. Stringer, Nilesh J. Samani, Shu Ye
Publikováno v:
Circulation Research. 131:1004-1017
Background: Genome-wide association studies have discovered a link between genetic variants on human chromosome 15q26.1 and increased coronary artery disease (CAD) susceptibility; however, the underlying pathobiological mechanism is unclear. This gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffdc37b7942c4b55537e56f5741ce571
https://doi.org/10.1161/circresaha.122.321146
https://doi.org/10.1161/circresaha.122.321146
Autor:
Ingrid Tarr, Stephanie Hesselson, Siiri E. Iismaa, Emma Rath, Steven Monger, Michael Troup, Ketan Mishra, Claire M.Y. Wong, Pei-Chen Hsu, Keerat Junday, David T. Humphreys, David Adlam, Tom R. Webb, Anna A. Baranowska-Clarke, Stephen E. Hamby, Keren J. Carss, Nilesh J. Samani, Monique Bax, Lucy McGrath-Cadell, Jason C. Kovacic, Sally L. Dunwoodie, Diane Fatkin, David W.M. Muller, Robert M. Graham, Eleni Giannoulatou
Publikováno v:
Circulation. Genomic and precision medicine. 15(4)
Background: Spontaneous coronary artery dissection (SCAD) is a cause of acute coronary syndrome that predominantly affects women. Its pathophysiology remains unclear but connective tissue disorders (CTD) and other vasculopathies have been observed in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa986447b04b2df8b621df51938acdb2
https://pubmed.ncbi.nlm.nih.gov/35980654
https://pubmed.ncbi.nlm.nih.gov/35980654
Autor:
Radoslaw Marek Debiec, Stephen E Hamby, Peter D Jones, Kassem Safwan, Michael Sosin, Simon Lee Hetherington, David Sprigings, David Sharman, Kelvin Lee, Pegah Salahshouri, Nigel Wheeldon, Andrew Chukwuemeka, Vasiliki Boutziouka, Mohamed Elamin, Sue Coolman, Manish Asiani, Shireen Kharodia, Gregory J Skinner, Nilesh J Samani, Tom R Webb, Aidan P Bolger
Publikováno v:
Heart. 108:1114-1120
IntroductionBicuspid aortic valve (BAV) affects 1% of the general population. NOTCH1 was the first gene associated with BAV. The proportion of familial and sporadic BAV disease attributed to NOTCH1 mutations has not been estimated.AimThe aim of our s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80f5ccb6fa290241099b924cef0a9c33
https://doi.org/10.1136/heartjnl-2021-320428
https://doi.org/10.1136/heartjnl-2021-320428
Autor:
Charles U. Solomon, David G. McVey, Catherine Andreadi, Peng Gong, Lanka Turner, Sonja Khemiri, Julie C. Chamberlain, Tom R. Webb, Nilesh J. Samani, Shu Ye
A significant portion of the RNA produced from the human genome consists of long non-coding RNAs (lncRNAs). These molecules tend to have lower levels of expression, are more specific to certain tissues, and show greater variation in expression betwee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db8258e69175cc9ac1312f31b0369812
https://doi.org/10.1101/2023.01.06.523019
https://doi.org/10.1101/2023.01.06.523019
Autor:
Elisavet, Karamanavi, David G, McVey, Sander W, van der Laan, Paulina J, Stanczyk, Gavin E, Morris, Yifan, Wang, Wei, Yang, Kenneth, Chan, Robin N, Poston, Jun, Luo, Xinmiao, Zhou, Peng, Gong, Peter D, Jones, Junjun, Cao, Renata B, Kostogrys, Tom R, Webb, Gerard, Pasterkamp, Haojie, Yu, Qingzhong, Xiao, Peter A, Greer, Emma J, Stringer, Nilesh J, Samani, Shu, Ye
Publikováno v:
Circulation research. 131(12)
Genome-wide association studies have discovered a link between genetic variants on human chromosome 15q26.1 and increased coronary artery disease (CAD) susceptibility; however, the underlying pathobiological mechanism is unclear. This genetic locus c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::33c10e34ff9a9b3fca56252495b255c9
https://pubmed.ncbi.nlm.nih.gov/36321446
https://pubmed.ncbi.nlm.nih.gov/36321446
Autor:
Charles U. Solomon, David G. McVey, Catherine Andreadi, Peng Gong, Lenka Turner, Paulina J. Stanczyk, Sonja Khemiri, Julie C. Chamberlain, Wei Yang, Tom R. Webb, Christopher P. Nelson, Nilesh J. Samani, Shu Ye
Publikováno v:
Circulation. 146(12)
Background: Genome-wide association studies have identified many genetic loci that are robustly associated with coronary artery disease (CAD). However, the underlying biological mechanisms are still unknown for most of these loci, hindering the progr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcfe759bdc30443933c305dc42c9f8b2
https://pubmed.ncbi.nlm.nih.gov/35735005
https://pubmed.ncbi.nlm.nih.gov/35735005
Autor:
Mark J. Caulfield, Li Zhang, Xiangyuan Pu, Shu Ye, Kenneth H. Chan, Chuan-ju Liu, Tom R. Webb, Wei Yang, Nilesh J. Samani, Jianhua Zhu, Andrew D. Moore, Qingzhong Xiao
Publikováno v:
Atherosclerosis. 296:11-17
Background and Aims: Recent studies have unveiled an association between ADAMTS7 gene variation and coronary artery disease (CAD) caused by atherosclerosis. We investigated if the ADAMTS7 Serine214-to-Proline substitution arising from a CAD-associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76894a07ae338bd4bec6ed928818f6d8
https://doi.org/10.1016/j.atherosclerosis.2020.01.015
https://doi.org/10.1016/j.atherosclerosis.2020.01.015
Autor:
Christopher P. Nelson, Shu Ye, Iziah E Sama, Chim C. Lang, Leong L. Ng, Tom R. Webb, Nilesh J. Samani, Veryan Codd, Adriaan A. Voors
Publikováno v:
Circulation, 142(11), 1117-1119. LIPPINCOTT WILLIAMS & WILKINS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a45087b20f943415d60c083af14b5e1b
https://doi.org/10.1161/circulationaha.120.049007
https://doi.org/10.1161/circulationaha.120.049007