Zobrazeno 1 - 10
of 158
pro vyhledávání: '"Tom P Fleming"'
Autor:
Judith J Eckert, Richard Porter, Adam J Watkins, Elizabeth Burt, Suzanne Brooks, Henry J Leese, Peter G Humpherson, Iain T Cameron, Tom P Fleming
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52791 (2012)
Previously, we have shown that a maternal low protein diet, fed exclusively during the preimplantation period of mouse development (Emb-LPD), is sufficient to induce by the blastocyst stage a compensatory growth phenotype in late gestation and postna
Externí odkaz:
https://doaj.org/article/d5491b019d7a4ffbbff1308a03aa6fc6
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28745 (2011)
Human and animal studies have revealed a strong association between periconceptional environmental factors, such as poor maternal diet, and an increased propensity for cardiovascular and metabolic disease in adult offspring. Previously, we reported c
Externí odkaz:
https://doaj.org/article/c1ec9f8e35064d35b525674dde25bb12
Autor:
Natalia Igosheva, Andrey Y Abramov, Lucilla Poston, Judith J Eckert, Tom P Fleming, Michael R Duchen, Josie McConnell
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10074 (2010)
The negative impact of obesity on reproductive success is well documented but the stages at which development of the conceptus is compromised and the mechanisms responsible for the developmental failure still remain unclear. Recent findings suggest t
Externí odkaz:
https://doaj.org/article/ba34669e199a4ecda526410553580cff
Autor:
Pooja Khurana, Andrew Cox, Barira Islam, Judith J. Eckert, Sandrine Willaime-Morawek, Joanna M. Gould, Neil R. Smyth, Patrick C. McHugh, Tom P. Fleming
Publikováno v:
Stem Cell Reviews and Reports. 19:767-783
Peri-conceptional environment can induce permanent changes in embryo phenotype which alter development and associate with later disease susceptibility. Thus, mouse maternal low protein diet (LPD) fed exclusively during preimplantation is sufficient t
Autor:
Diego A Ojeda, Oliver Hutton, Robert Hopkins, Felino Cagampang, Neil R Smyth, Tom P Fleming, Judith Eckert, Sandrine Willaime-Morawek
Publikováno v:
Brain Communications. 5
Poor maternal nutrition during pregnancy is known to impair fetal development. Moreover, the preimplantation period is vulnerable to adverse programming of disease. Here, we investigated the effect of a mouse maternal high-fat diet in healthy non-obe
Autor:
Keith M. Godfrey, Judith Stephenson, Kathryn Woods-Townsend, Mary Barker, Tom P. Fleming, Mark Vickers, Frank Bloomfield, Rachael Taylor
Publikováno v:
Developmental Origins of Health and Disease ISBN: 9781009272254
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed442367b8daf92c1e1e3c963b1afd86
https://doi.org/10.1017/9781009272254.004
https://doi.org/10.1017/9781009272254.004
Autor:
Neil Smyth, Judith J. Eckert, Miguel A. Velazquez, Bhavwanti Sheth, Tom P. Fleming, Pooja Khurana
Publikováno v:
Journal of Developmental Origins of Health and Disease. 13:395-405
Advanced maternal age (AMA) is known to reduce fertility, increases aneuploidy in oocytes and early embryos and leads to adverse developmental consequences which may associate with offspring lifetime health risks. However, investigating underlying ef
Autor:
Reyna S Penailillo, M A Burton, Graham C. Burdge, Karen A. Lillycrop, Judith J. Eckert, Tom P. Fleming
Publikováno v:
Molecular Reproduction and Development. 88:261-273
Folate, a cofactor for the supply of one-carbon groups, is required by epigenetic processes to regulate cell lineage determination during development. The intake of folic acid (FA), the synthetic form of folate, has increased significantly over the p
Autor:
Richard O.C. Oreffo, Adam J. Watkins, Judith J. Eckert, Emma S. Lucas, Niamh MacCaoilte, Stephanie J. Smith, Tom P. Fleming, Stuart A. Lanham
Publikováno v:
Journal of Developmental Origins of Health and Disease. 12:384-395
Adverse programming of adult non-communicable disease can be induced by poor maternal nutrition during pregnancy and the periconception period has been identified as a vulnerable period. In the current study, we used a mouse maternal low-protein diet
Autor:
Tom P. Fleming
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Parental health and diet at the time of conception determine the development and life-long disease risk of their offspring. While the association between poor maternal diet and offspring health is well established, the underlying mechani