Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Tom N. Grammatopoulos"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Liposomal formulations are hypothesized to alleviate anthracycline cardiotoxicity, although this has only been documented clinically for doxorubicin. We developed an in vitro multiparametric model using human-induced pluripotent stem cell-de
Externí odkaz:
https://doaj.org/article/591049cf8eba4849b8e9bae68b13485b
Autor:
Sebastiaan J. W. vanKraaij, Diana R. Pereira, Bastiaan Smal, Luciana Summo, Anne Konkel, Janine Lossie, Andreas Busjahn, Tom N. Grammatopoulos, Erica Klaassen, Robert Fischer, Wolf‐Hagen Schunck, Pim Gal, Matthijs Moerland
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 7, Pp 1258-1271 (2023)
Abstract The development of pharmacological therapies for mitochondrial diseases is hampered by the lack of tissue‐level and circulating biomarkers reflecting effects of compounds on endothelial and mitochondrial function. This phase 0 study aimed
Externí odkaz:
https://doaj.org/article/994c545b4faf49d8965af13ecec37248
Autor:
Leah K. Cuddy, Alia O. Alia, Miranda A. Salvo, Sidhanth Chandra, Tom N. Grammatopoulos, Craig J. Justman, Peter T. Lansbury, Joseph R. Mazzulli, Robert Vassar
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-23 (2022)
Abstract Background Amyloid plaque deposition and axonal degeneration are early events in AD pathogenesis. Aβ disrupts microtubules in presynaptic dystrophic neurites, resulting in the accumulation of impaired endolysosomal and autophagic organelles
Externí odkaz:
https://doaj.org/article/e44cfb2c142247068fdf496e4be970c6
Autor:
Sebastiaan J. W. van Kraaij, Diana R. Pereira, Bastiaan Smal, Luciana Summo, Anne Konkel, Janine Lossie, Andreas Busjahn, Tom N. Grammatopoulos, Erica Klaassen, Robert Fischer, Wolf‐Hagen Schunck, Pim Gal, Matthijs Moerland
The development of pharmacological therapies for mitochondrial diseases is hampered by the lack of tissue-level and circulating biomarkers reflecting effects of compounds on endothelial and mitochondrial function. This phase 0 study aimed to identify
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e89dc274fab140f77179c6c3db555d4e
http://edoc.mdc-berlin.de/23361/1/23361oa.pdf
http://edoc.mdc-berlin.de/23361/1/23361oa.pdf
Autor:
Dequina Nicholas, Elizabeth A Proctor, Forum M Raval, Blanche C Ip, Chloe Habib, Eleni Ritou, Tom N Grammatopoulos, Devin Steenkamp, Hans Dooms, Caroline M Apovian, Douglas A Lauffenburger, Barbara S Nikolajczyk
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0170975 (2017)
Numerous studies show that mitochondrial energy generation determines the effectiveness of immune responses. Furthermore, changes in mitochondrial function may regulate lymphocyte function in inflammatory diseases like type 2 diabetes. Analysis of ly
Externí odkaz:
https://doaj.org/article/b133ec24293647c7aa0023d6c157c216
Autor:
James R. Klinger, Corey E. Ventetuolo, Anyu Zhou, Amy Palmisciano, Debasree Banerjee, Samuel C. Dudley, Ipsita Krishnan, Tom N. Grammatopoulos, Mary Whittenhall
Publikováno v:
Chest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e395e0fce2dcbce4e1d4d5272275deca
https://doi.org/10.1016/j.chest.2019.12.052
https://doi.org/10.1016/j.chest.2019.12.052
Stress-Induced Cellular Clearance Is Mediated by the SNARE Protein ykt6 and Disrupted by α-Synuclein
Autor:
Nandkishore R. Belur, Kristina Fredriksen, Willayat Yousuf Wani, Craig J. Justman, Friederike Zunke, Martino L. Morella, Kotaro Tsutsumi, Aarthi Subramanian, Tom N. Grammatopoulos, Peter T. Lansbury, Caleb Pitcairn, Leah K. Cuddy, Amira Affaneh, Joseph R. Mazzulli
Publikováno v:
Neuron
Summary Age-related neurodegenerative disorders are characterized by a slow, persistent accumulation of aggregated proteins. Although cells can elicit physiological responses to enhance cellular clearance and counteract accumulation, it is unclear ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f9cd92c993d6e001d3bb01449eff9d6
https://doi.org/10.1016/j.neuron.2019.09.001
https://doi.org/10.1016/j.neuron.2019.09.001
Autor:
Lisl K.M. Shoda, Paul B. Watkins, Linsey Stiles, Tom N. Grammatopoulos, Jeffrey L. Woodhead, Sharin E. Roth, Kim L. R. Brouwer, Merrie Mosedale, William J. Brock, Susan E. Shoaf, Brett A. Howell, Rachel J. Church, Scott Q. Siler
Publikováno v:
Toxicological Sciences
Tolvaptan is a selective vasopressin V2 receptor antagonist, approved in several countries for the treatment of hyponatremia and autosomal dominant polycystic kidney disease (ADPKD). No liver injury has been observed with tolvaptan treatment in healt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::341d1fd1faffb94b8e2734024d28307d
Autor:
Barbara S. Nikolajczyk, Blanche C. Ip, Caroline M. Apovian, Eleni Ritou, Elizabeth A. Proctor, Devin Steenkamp, Tom N. Grammatopoulos, Chloe Habib, Douglas A. Lauffenburger, Hans Dooms, Dequina A. Nicholas, Forum M. Raval
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0170975 (2017)
PLoS ONE
PLoS
PLoS ONE
PLoS
Numerous studies show that mitochondrial energy generation determines the effectiveness of immune responses. Furthermore, changes in mitochondrial function may regulate lymphocyte function in inflammatory diseases like type 2 diabetes. Analysis of ly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2172370e52bfb6f624fa9c4ad4fe9e57
http://europepmc.org/articles/PMC5298256?pdf=render
http://europepmc.org/articles/PMC5298256?pdf=render
Autor:
Robin K. Meray, Peter T. Lansbury, Tom N. Grammatopoulos, Zhihua Liu, Todd P. Logan, Yichin Liu, Mark R. Cookson, Ross A. Fredenburg
Publikováno v:
Proceedings of the National Academy of Sciences. 106:4635-4640
Ubiquitin C-terminal hydrolase-L1 (UCH-L1) is linked to Parkinson's disease (PD) and memory and is selectively expressed in neurons at high levels. Its expression pattern suggests a function distinct from that of its widely expressed homolog UCH-L3.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7f110131c8dd6eaea2c938dea9cd4e5
https://doi.org/10.1073/pnas.0806474106
https://doi.org/10.1073/pnas.0806474106