Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Tom N. Durrant"'
Autor:
Lara C. Lewis, Lingyan Chen, L. Shahul Hameed, Robert R. Kitchen, Cyrielle Maroteau, Shilpa R. Nagarajan, Jenny Norlin, Charlotte E. Daly, Iwona Szczerbinska, Sara Toftegaard Hjuler, Rahul Patel, Eilidh J. Livingstone, Tom N. Durrant, Elisabeth Wondimu, Soumik BasuRay, Anandhakumar Chandran, Wan-Hung Lee, Sile Hu, Barak Gilboa, Megan E. Grandi, Enrique M. Toledo, Abdullah H.A. Erikat, Leanne Hodson, William G. Haynes, Natalie W. Pursell, Ken Coppieters, Jan Fleckner, Joanna M.M. Howson, Birgitte Andersen, Maxwell A. Ruby
Publikováno v:
JHEP Reports, Vol 5, Iss 5, Pp 100693- (2023)
Background & Aims: Non-alcoholic fatty liver disease (NAFLD) has a prevalence of ∼25% worldwide, with significant public health consequences yet few effective treatments. Human genetics can help elucidate novel biology and identify targets for new
Externí odkaz:
https://doaj.org/article/dfadb6aa5c1e408c8dd0a8e68452c677
Autor:
Tom N. Durrant, Ingeborg Hers
Publikováno v:
Clinical and Translational Medicine, Vol 9, Iss 1, Pp 1-21 (2020)
Abstract Phosphoinositide 3-kinases (PI3Ks) are lipid kinases that regulate important intracellular signalling and vesicle trafficking events via the generation of 3-phosphoinositides. Comprising eight core isoforms across three classes, the PI3K fam
Externí odkaz:
https://doaj.org/article/14b1accc890040659e09bf8db830c8e5
Autor:
Tom N. Durrant, James L. Hutchinson, Kate J. Heesom, Karen E. Anderson, Len R. Stephens, Phillip T. Hawkins, Aaron J. Marshall, Samantha F. Moore, Ingeborg Hers
Publikováno v:
Blood Advances, Vol 1, Iss 14, Pp 918-932 (2017)
Abstract: The class I phosphoinositide 3-kinase (PI3K) isoforms play important roles in platelet priming, activation, and stable thrombus formation. Class I PI3Ks predominantly regulate cell function through their catalytic product, the signaling pho
Externí odkaz:
https://doaj.org/article/0aae918fd93a45f4afea1c0cda863f63
Autor:
Samantha F. Moore, Marieangela C. Wilson, Yiliang Jiang, Ingeborg Hers, Tom N. Durrant, Asha L. Bayliss, Elizabeth W. Aitken, Kate J. Heesom
Publikováno v:
Durrant, T N, Moore, S F, Bayliss, A L, Jiang, Y, Aitken, E W, Wilson, M C, Heesom, K J & Hers, I 2020, ' Identification of PtdIns(3,4)P 2 effectors in human platelets using quantitative proteomics ', Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, vol. 1865, no. 2, 158575 . https://doi.org/10.1016/j.bbalip.2019.158575
After decades in PtdIns(3,4,5)P3's shadow, PtdIns(3,4)P2 has now emerged as a bona fide regulator of important cellular events, including endocytosis and cell migration. New understanding of PtdIns(3,4)P2's cellular roles has been possible via novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f83e5d8139f11a6df637f20ec07d061
https://hdl.handle.net/1983/05093447-5f5c-4e41-bce6-b48c02affa3e
https://hdl.handle.net/1983/05093447-5f5c-4e41-bce6-b48c02affa3e
Autor:
Ingeborg Hers, Samantha F. Moore, Karen E. Anderson, James L Hutchinson, Aaron J. Marshall, Tom N. Durrant, Kate J. Heesom, Len R. Stephens, Phillip T. Hawkins
Publikováno v:
Durrant, T, Hutchinson, L, Heesom, K, Anderson, K, Stephens, L, Hawkins, P, Marshall, A, Moore, S & Hers, I 2017, ' In-depth PtdIns(3,4,5)P3 signalosome analysis identifies DAPP1 as a negative regulator of GPVIdriven platelet function ', Blood Advances, vol. 1, no. 14, pp. 918-932 . https://doi.org/10.1182/bloodadvances.2017005173
The Class I Phosphoinositide 3-kinase (PI3K) isoforms play important roles in platelet priming, activation and stable thrombus formation. Class I PI3Ks predominantly regulate cell function through their catalytic product, the signaling phospholipid p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae313323d68adf37ed028624a05b6bf0
https://doi.org/10.1182/bloodadvances.2017005173
https://doi.org/10.1182/bloodadvances.2017005173
Autor:
Tom N, Durrant, Samantha F, Moore, Asha L, Bayliss, Yiliang, Jiang, Elizabeth W, Aitken, Marieangela C, Wilson, Kate J, Heesom, Ingeborg, Hers
Publikováno v:
Biochimica et biophysica acta. Molecular and cell biology of lipids. 1865(2)
After decades in PtdIns(3,4,5)P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fef97a58ad646c74d7062af139ea4b2e
https://pubmed.ncbi.nlm.nih.gov/31743753
https://pubmed.ncbi.nlm.nih.gov/31743753
Autor:
Samantha F. Moore, Kamila M. Śledź, Roger W. Hunter, Thomas A. Blair, Ingeborg Hers, Tom N. Durrant
Publikováno v:
Biochemical Pharmacology. 177:113975
Background and Purpose Rapamycin is a potent immunosuppressant and anti-proliferative agent used clinically to prevent organ transplant rejection and for coating coronary stents to counteract restenosis. Rapamycin complexes with the immunophilin FKBP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbcbc88283bd17a7d2f94eae2beb968c
https://doi.org/10.1016/j.bcp.2020.113975
https://doi.org/10.1016/j.bcp.2020.113975
Autor:
James L Hutchinson, Alastair W. Poole, Karen E. Anderson, Thomas A. Blair, Samantha F. Moore, Tony G. Walsh, Ingeborg Hers, Tom N. Durrant
Publikováno v:
Blair, T A, Moore, S F, Walsh, T G, Hutchinson, J L, Durrant, T N, Anderson, K E, Poole, A W & Hers, I 2018, ' Phosphoinositide 3-kinase p110α negatively regulates thrombopoietin-mediated platelet activation and thrombus formation ', Cellular Signalling, vol. 50, pp. 111-120 . https://doi.org/10.1016/j.cellsig.2018.05.005
Phosphoinositide 3-kinase (PI3K) plays an important role in platelet function and contributes to platelet hyperreactivity induced by elevated levels of circulating peptide hormones, including thrombopoietin (TPO). Previous work established an importa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cac155781a938e6b04d3bc65b518dcae
https://research-information.bris.ac.uk/en/publications/0793c2dd-4dff-411e-8056-4ef37efa767a
https://research-information.bris.ac.uk/en/publications/0793c2dd-4dff-411e-8056-4ef37efa767a
Publikováno v:
Scientific Reports
Thrombopoietin (TPO) enhances platelet activation through activation of the tyrosine kinase; JAK2 and the lipid kinase phosphatidylinositide 3-kinase (PI3K). The aim of our study was to identify the PI3K isoforms involved in mediating the effect of T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bf8f44669d307987d5cfd2d714f78b4b
https://pubmed.ncbi.nlm.nih.gov/30728366
https://pubmed.ncbi.nlm.nih.gov/30728366
Integrin αIIbβ3 is a highly abundant heterodimeric platelet receptor that can transmit information bidirectionally across the plasma membrane, and plays a critical role in hemostasis and thrombosis. Upon platelet activation, inside-out signaling pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e200ea4d37dd9f6985923e4df6cc987
https://europepmc.org/articles/PMC5672329/
https://europepmc.org/articles/PMC5672329/