Zobrazeno 1 - 10
of 2 478
pro vyhledávání: '"Tom N"'
Autor:
Candy Laura Steffen, Ganesh babu Manoharan, Karolina Pavic, Alejandro Yeste-Vázquez, Matias Knuuttila, Neha Arora, Yong Zhou, Harri Härmä, Anthoula Gaigneaux, Tom N. Grossmann, Daniel Kwaku Abankwa
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract Hyperactive Ras signalling is found in most cancers. Ras proteins are only active in membrane nanoclusters, which are therefore potential drug targets. We previously showed that the nanocluster scaffold galectin-1 (Gal1) enhances H-Ras nanoc
Externí odkaz:
https://doaj.org/article/824fba21fa7f4eef9a59a3a33f13cb35
Autor:
Holly Hill, David Reddick, Gastón Caspe, Clifford Ramage, David Frew, Mara S. Rocchi, Tanja Opriessnig, Tom N. McNeilly
Publikováno v:
Virus Research, Vol 348, Iss , Pp 199443- (2024)
Atypical porcine pestivirus (APPV) is a novel member of the Pestivirus genus detected in association with congenital tremor (CT) type A-II outbreaks and from apparently healthy pigs, both as singular infection and as part of multi-pathogen infections
Externí odkaz:
https://doaj.org/article/81659fb6a78748f8a18aff8642166dd0
Autor:
Andrew D. Dean, Dylan Z. Childs, Yolanda Corripio‐Miyar, Mike Evans, Adam Hayward, Fiona Kenyon, Luke McNally, Tom N. McNeilly, Robin J. Pakeman, Amy R. Sweeny, Daniel H. Nussey, Amy B. Pedersen, Andy Fenton
Publikováno v:
Ecology and Evolution, Vol 14, Iss 6, Pp n/a-n/a (2024)
Abstract Organisms have evolved diverse strategies to manage parasite infections. Broadly, hosts may avoid infection by altering behaviour, resist infection by targeting parasites or tolerate infection by repairing associated damage. The effectivenes
Externí odkaz:
https://doaj.org/article/d371a39c523f45c8a6a6da738037d8ac
Autor:
Alasdair J. Nisbet, Tom N. McNeilly, Daniel R. G. Price, Yvonne Bartley, Margaret Oliver, Dave McBean, Leigh Andrews, Gillian Mitchell, Rachael Duncan, Sarah Brocklehurst, Fiona Kenyon
Publikováno v:
Frontiers in Parasitology, Vol 3 (2024)
IntroductionWe previously demonstrated efficacy of an 8-antigen recombinant subunit vaccine against a single species homologous Teladorsagia circumcincta challenge in lambs and in lambing ewes in pen trials. We subsequently demonstrated efficacy of a
Externí odkaz:
https://doaj.org/article/d46a8cfd69204748bf58369110292154
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Liposomal formulations are hypothesized to alleviate anthracycline cardiotoxicity, although this has only been documented clinically for doxorubicin. We developed an in vitro multiparametric model using human-induced pluripotent stem cell-de
Externí odkaz:
https://doaj.org/article/591049cf8eba4849b8e9bae68b13485b
Autor:
Sebastiaan J. W. vanKraaij, Diana R. Pereira, Bastiaan Smal, Luciana Summo, Anne Konkel, Janine Lossie, Andreas Busjahn, Tom N. Grammatopoulos, Erica Klaassen, Robert Fischer, Wolf‐Hagen Schunck, Pim Gal, Matthijs Moerland
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 7, Pp 1258-1271 (2023)
Abstract The development of pharmacological therapies for mitochondrial diseases is hampered by the lack of tissue‐level and circulating biomarkers reflecting effects of compounds on endothelial and mitochondrial function. This phase 0 study aimed
Externí odkaz:
https://doaj.org/article/994c545b4faf49d8965af13ecec37248
Autor:
Emil Bach, Stephen F. Fitzgerald, Sarah E. Williams-MacDonald, Mairi Mitchell, William T. Golde, David Longbottom, Alasdair J. Nisbet, Annemieke Dinkla, Eric Sullivan, Richard S. Pinapati, John C. Tan, Leo A. B. Joosten, Hendrik-Jan Roest, Thomas Østerbye, Ad P. Koets, Søren Buus, Tom N. McNeilly
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Coxiella burnetii is an important zoonotic bacterial pathogen of global importance, causing the disease Q fever in a wide range of animal hosts. Ruminant livestock, in particular sheep and goats, are considered the main reservoir of human infection.
Externí odkaz:
https://doaj.org/article/55700a5c8dce43b49b05a921f1048029
Autor:
Frédéric Douhard, Andrea B. Doeschl‐Wilson, Alexander Corbishley, Adam D. Hayward, Didier Marcon, Jean‐Louis Weisbecker, Sophie Aguerre, Léa Bordes, Philippe Jacquiet, Tom N. McNeilly, Guillaume Sallé, Carole Moreno‐Romieux
Publikováno v:
Evolutionary Applications, Vol 15, Iss 9, Pp 1374-1389 (2022)
Abstract Trade‐offs between host resistance to parasites and host growth or reproduction can occur due to allocation of limited available resources between competing demands. To predict potential trade‐offs arising from genetic selection for host
Externí odkaz:
https://doaj.org/article/d4892cc4379348f39e396ea3ae192d54
Autor:
Leah K. Cuddy, Alia O. Alia, Miranda A. Salvo, Sidhanth Chandra, Tom N. Grammatopoulos, Craig J. Justman, Peter T. Lansbury, Joseph R. Mazzulli, Robert Vassar
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-23 (2022)
Abstract Background Amyloid plaque deposition and axonal degeneration are early events in AD pathogenesis. Aβ disrupts microtubules in presynaptic dystrophic neurites, resulting in the accumulation of impaired endolysosomal and autophagic organelles
Externí odkaz:
https://doaj.org/article/e44cfb2c142247068fdf496e4be970c6
Autor:
Wei Liu, Tom N. McNeilly, Mairi Mitchell, Stewart T. G. Burgess, Alasdair J. Nisbet, Jacqueline B. Matthews, Simon A. Babayan
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-9 (2022)
Abstract Individuals vary broadly in their response to vaccination and subsequent challenge infection, with poor vaccine responders causing persistence of both infection and transmission in populations. Yet despite having substantial economic and soc
Externí odkaz:
https://doaj.org/article/b0ab7ef1bd73424bba4272f507507e87