Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Tom McKevitt"'
Autor:
Piotr J. Kamola, Klio Maratou, Paul A. Wilson, Kay Rush, Tanya Mullaney, Tom McKevitt, Paula Evans, Jim Ridings, Probash Chowdhury, Aude Roulois, Ann Fairchild, Sean McCawley, Karen Cartwright, Nigel J. Gooderham, Timothy W. Gant, Kitty Moores, Stephen A. Hughes, Mark R. Edbrooke, Kenneth Clark, Joel D. Parry
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 8, Iss , Pp 383-394 (2017)
Antisense oligonucleotide (ASO) gapmers downregulate gene expression by inducing enzyme-dependent degradation of targeted RNA and represent a promising therapeutic platform for addressing previously undruggable genes. Unfortunately, their therapeutic
Externí odkaz:
https://doaj.org/article/b04a0634ef634c9784c5c5759a036d27
Autor:
Angela Deakin, Graham Duddy, Steve Wilson, Steve Harrison, Judi Latcham, Mick Fulleylove, Sylvia Fung, Jason Smith, Mike Pedrick, Tom McKevitt, Leigh Felton, Joanne Morley, Diana Quint, Dilniya Fattah, Brian Hayes, Jade Gough, Roberto Solari
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107490 (2014)
Interleukin-2 inducible tyrosine kinase (ITK) is expressed in T cells and plays a critical role in signalling through the T cell receptor. Evidence, mainly from knockout mice, has suggested that ITK plays a particularly important function in Th2 cell
Externí odkaz:
https://doaj.org/article/d1d949c2f0704f36a96334e7c5b4b83c
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 3, Iss 4, Pp 351-359 (2001)
Studies on telomere and telomerase biology are fundamental to the understanding of aging and age-related diseases such as cancer. However, human studies have been hindered by differences in telomere biology between humans and the classical murine ani
Externí odkaz:
https://doaj.org/article/69835f14e7234cd885467eb1fc632848
Autor:
Klio Maratou, Tom McKevitt, Piotr J. Kamola, Aude Roulois, Kay Rush, Probash Chowdhury, Stephen A. Hughes, Kitty Moores, Timothy W. Gant, Paula Evans, Paul A. Wilson, Joel D. Parry, Mark R. Edbrooke, Jim Ridings, Ann Fairchild, Tanya M. Mullaney, Nigel J. Gooderham, Kenneth L. Clark, Sean J. McCawley, Karen Cartwright
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 8, Iss, Pp 383-394 (2017)
Molecular Therapy. Nucleic Acids
Molecular Therapy. Nucleic Acids
Antisense oligonucleotide (ASO) gapmers downregulate gene expression by inducing enzyme-dependent degradation of targeted RNA and represent a promising therapeutic platform for addressing previously undruggable genes. Unfortunately, their therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e2d3ad4e6d2bbc9d02dfee92fa6f197
http://www.sciencedirect.com/science/article/pii/S2162253117302135
http://www.sciencedirect.com/science/article/pii/S2162253117302135
Autor:
Aude Roulois, Deon Hildebrand, Tom McKevitt, Dave Hassall, Jeffrey K. Huang, S J Bolton, Joel D. Parry, Mary McFarlane, Stefano Pluchino, Rajni Fagg, Wolfgang Brück
Publikováno v:
Toxicologic Pathology. 40:122-125
Abbreviations: ASC, adult stem cell line; CNS, central nervous system; COPD, chronic obstructive pulmonary disease; MS, multiple sclerosis; MSC, mesenchymal stem cell; NPCs, neural stem/precursor cells; OPCs, oligodendrocyte precursor cells; RNA, rib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3978b1a0ecee468a31fe7de1c448a44
https://doi.org/10.1177/0192623311425064
https://doi.org/10.1177/0192623311425064
Autor:
Steve A. Papworth, Jan Osborne, David J. Lewis, Paul Beard, Paul Giffen, Paul McGill, Tom McKevitt, Jan Klapwijk, Tom C. Williams, Jennie A. Woodfine, Sean J. McCawley
Publikováno v:
Toxicologic Pathology. 39:958-968
The purpose of this study was to compare the toxicity of three marketed corticosteroid receptor agonists (mometasone furoate, budesonide, or flunisolide) to the stomach of female CD-1 mice following oral administration via the diet for up to 52 weeks
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d67dc934b53a3c9a23cb7cd039be82a0
https://doi.org/10.1177/0192623311418681
https://doi.org/10.1177/0192623311418681
Autor:
David J. Lewis, Jennie A. Woodfine, Thomas C. Williams, Takahito Kambara, S. E. Campbell, Tom McKevitt, Ian Francis
Publikováno v:
Toxicologic Pathology. 35:179-197
Large eosinophilic cytoplasmic inclusions (ECIs) are occasionally seen in the bronchiolar epithelium of control rats. Increased ECls were recently observed in rats treated with an inhaled corticosteroid. Little information is available about these EC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c08fab333086ed43c73cf1a4ac31d936
https://doi.org/10.1080/01926230601172119
https://doi.org/10.1080/01926230601172119
Autor:
Jason C. Smith, Mike Pedrick, Tom McKevitt, Steve Wilson, Joanne Morley, Sylvia Fung, Angela M. Deakin, Leigh M. Felton, Graham Duddy, Steve Mark Harrison, Roberto Solari, Dilniya Fattah, Judi Latcham, Brian Hayes, Mick Fulleylove, Diana Quint, Jade Gough
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107490 (2014)
PLoS ONE
PLoS ONE
Interleukin-2 inducible tyrosine kinase (ITK) is expressed in T cells and plays a critical role in signalling through the T cell receptor. Evidence, mainly from knockout mice, has suggested that ITK plays a particularly important function in Th2 cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba607147a42e4b5b791af64bb57d72f4
http://europepmc.org/articles/PMC4174519?pdf=render
http://europepmc.org/articles/PMC4174519?pdf=render
Autor:
Tom McKevitt, Stewart A. Jones, David J. Lewis, Ian Francis, Andrew M. Pilling, Jennie A. Woodfine, Thomas C. Williams, Sean J. McCawley, Takahito Kambara
Publikováno v:
Toxicologic pathology. 37(3)
Large eosinophilic cytoplasmic inclusions (ECIs) are occasionally seen in untreated rat Clara cells. Following inhalation exposure to a corticosteroid, the number of ECIs was increased. This is the first histopathological description of rat ECIs and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c8df9c890aa8828fc6818716b24a61d
https://pubmed.ncbi.nlm.nih.gov/19380841
https://pubmed.ncbi.nlm.nih.gov/19380841