Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Tom MacLeod"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Historically inflammation against self was considered autoimmune which stems back to the seminal observations by Ehrlich who described serum factors, now known to be autoantibodies produced by B lineage cells that mediate “horror autotoxicus”. Th
Externí odkaz:
https://doaj.org/article/f06352ab02564fa6a2441cac83b4d998
Autor:
Abdulla Watad, Dennis G McGonagle, Howard Amital, Tom Macleod, Or Hen, Paula David, Niv Ben-Shabbat
Publikováno v:
RMD Open, Vol 10, Iss 2 (2024)
Objective Obesity and age are strongly linked to severe COVID-19 pneumonia where immunomodulatory agents including Janus kinase inhibitors have shown benefits but the efficacy of such therapy in viral pneumonia is not well understood. We evaluated th
Externí odkaz:
https://doaj.org/article/ee103318fd3e4afca66fd64e3d8140f2
Autor:
Dennis G McGonagle, Nathan J Dean, Ian J Clifton, Rashad Salman, Charles Bridgewood, Jacquie Nam, Tom Macleod
Publikováno v:
RMD Open, Vol 9, Iss 4 (2023)
Objective The increasing use of biological therapies has led to the paradoxical finding that monoclonal antibody therapy for one inflammatory disease can sometimes induce another inflammatory disease. Recently, the use of anti-IL-5 (IL, interleukin)
Externí odkaz:
https://doaj.org/article/0707d3cec695420b8515530013984e4a
Publikováno v:
Pharmaceuticals, Vol 16, Iss 9, p 1286 (2023)
The p38 mitogen-activated protein kinase (p38-MAPK) is a crucial signaling pathway closely involved in several physiological and cellular functions, including cell cycle, apoptosis, gene expression, and responses to stress stimuli. It also plays a ce
Externí odkaz:
https://doaj.org/article/f7af4bdecb7a49c99c5498416e284e39
Autor:
Tom Macleod, Anna Berekmeri, Charlie Bridgewood, Martin Stacey, Dennis McGonagle, Miriam Wittmann
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The skin barrier would not function without IL-1 family members, but their physiological role in the immunological aspects of skin barrier function are often overlooked. This review summarises the role of IL-1 family cytokines (IL-1α, IL-1β, IL-1Ra
Externí odkaz:
https://doaj.org/article/81b21c05d1f047d4bba0270b9bf448e9
Autor:
Tom Macleod, Joseph Ward, Adewonuola A. Alase, Charlie Bridgewood, Miriam Wittmann, Nicola J. Stonehouse
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
RNA aptamers are synthetic single stranded RNA oligonucleotides that function analogously to antibodies. Recently, they have shown promise for use in treating inflammatory skin disease as, unlike antibody-based biologics, they are able to enter the s
Externí odkaz:
https://doaj.org/article/3a83fb3a17df420888ec18e6f9b9c31d
Autor:
Charlie Bridgewood, Gareth W. Fearnley, Anna Berekmeri, Philip Laws, Tom Macleod, Sreenivasan Ponnambalam, Martin Stacey, Anne Graham, Miriam Wittmann
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
The IL-1 family member cytokine IL-36γ is recognised as key mediator in the immunopathology of psoriasis, hallmarks of which involve the activation of both resident and infiltrating inflammatory myeloid cells and aberrant angiogenesis. This research
Externí odkaz:
https://doaj.org/article/18b2841b2c65416fa826a005d1348c64
Publikováno v:
The Lancet Rheumatology. 5:e47-e57
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80e2e0aad08b6c41dda83b36e07a0cfb
https://doi.org/10.1016/s2665-9913(22)00334-4
https://doi.org/10.1016/s2665-9913(22)00334-4
Autor:
Charlie Bridgewood, Miriam Wittmann, Tom Macleod, Abdulla Watad, Darren Newton, Kanchan Bhan, Howard Amital, Giovanni Damiani, Sami Giryes, Nicola Luigi Bragazzi, Dennis McGonagle
Publikováno v:
Journal of Investigative Dermatology. 142:2660-2667
Dupilumab, an IL-4/IL-13 receptor blocker, has been linked to emergent seronegative inflammatory arthritis and psoriasis that form part of the spondyloarthropathy spectrum. We systematically investigated patterns of immune disorders, including predom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73544235f8dfb519543fb697e5e5224c
https://doi.org/10.1016/j.jid.2022.03.013
https://doi.org/10.1016/j.jid.2022.03.013
Autor:
Tom Macleod, Charles Bridgewood, Isabel Hyde, Megan Heague, Philip Helliwell, Martin Stacey, Miriam Wittmann
Publikováno v:
Clinical Science. 136:935-952
This review highlights the molecular and cellular mechanisms underlying psoriatic inflammation with an emphasis on recent developments which may impact on treatment approaches for this chronic disease. We consider both the skin and the musculoskeleta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba76fcf52ec3a20db601d373523b47d2
https://doi.org/10.1042/cs20210916
https://doi.org/10.1042/cs20210916