Histone lysine demethylase inhibition reprograms prostate cancer metabolism and mechanics

Autor: Ugo Chianese, Chiara Papulino, Eugenia Passaro, Tom MJ. Evers, Mehrad Babaei, Antonella Toraldo, Tommaso De Marchi, Emma Niméus, Vincenzo Carafa, Maria Maddalena Nicoletti, Nunzio Del Gaudio, Nunzia Iaccarino, Antonio Randazzo, Dante Rotili, Antonello Mai, Salvatore Cappabianca, Alireza Mashaghi, Fortunato Ciardiello, Lucia Altucci, Rosaria Benedetti

Publikováno v: Molecular Metabolism, Vol 64, Iss , Pp 101561- (2022)

Objective: Aberrant activity of androgen receptor (AR) is the primary cause underlying development and progression of prostate cancer (PCa) and castration-resistant PCa (CRPC). Androgen signaling regulates gene transcription and lipid metabolism, fac

Externí odkaz: https://doaj.org/article/df67d4dd16fd48ec98c9149449174dcf

Comparison of automated percutaneous kidney biopsy using needles of different gauge

Autor: Ross R. Bailey, Jacqui Gardner, Geoffrey J Welsh, Richard A. Robson, Kelvin L. Lynn, Tom Mj Maling, Lance Lawler, Kim Ming Wong

Publikováno v: Nephrology. 3:211-214

Summary: Percutaneous renal biopsy, an essential procedure for the evaluation of a patient with renal disease, has been improved by the use of semi-automated, spring-loaded renal biopsy guns. We have carried out a prospective, randomized study compar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::826bb8af1cdbe3f4918300e8c17cc780
https://doi.org/10.1111/j.1440-1797.1997.tb00217.x

Identifying general reaction conditions by bandit optimization.

Autor: Wang JY; Department of Chemistry, Princeton University, Princeton, NJ, USA.; Department of Chemistry and Biochemistry, University of California, Los Angeles, CA, USA., Stevens JM; Chemical Process Development, Bristol Myers Squibb, Summit, NJ, USA., Kariofillis SK; Department of Chemistry, Princeton University, Princeton, NJ, USA.; Department of Chemistry and Biochemistry, University of California, Los Angeles, CA, USA.; Department of Chemistry, Columbia University, New York, NY, USA., Tom MJ; Department of Chemistry and Biochemistry, University of California, Los Angeles, CA, USA., Golden DL; Chemical Process Development, Bristol Myers Squibb, Summit, NJ, USA., Li J; Chemical Process Development, Bristol Myers Squibb, New Brunswick, NJ, USA., Tabora JE; Chemical Process Development, Bristol Myers Squibb, New Brunswick, NJ, USA., Parasram M; Department of Chemistry, Princeton University, Princeton, NJ, USA.; Department of Chemistry, New York University, New York, NY, USA., Shields BJ; Department of Chemistry, Princeton University, Princeton, NJ, USA.; Molecular Structure and Design, Bristol Myers Squibb, Cambridge, MA, USA., Primer DN; Chemical Process Development, Bristol Myers Squibb, Summit, NJ, USA.; Loxo Oncology at Lilly, Louisville, CO, USA., Hao B; Janssen Research and Development, Spring House, PA, USA., Del Valle D; Chemical Process Development, Bristol Myers Squibb, New Brunswick, NJ, USA., DiSomma S; Chemical Process Development, Bristol Myers Squibb, New Brunswick, NJ, USA., Furman A; Chemical Process Development, Bristol Myers Squibb, New Brunswick, NJ, USA., Zipp GG; Discovery Synthesis, Bristol Myers Squibb, Princeton, NJ, USA., Melnikov S; Spectrix Analytical Services, North Haven, CT, USA., Paulson J; Chemical Process Development, Bristol Myers Squibb, New Brunswick, NJ, USA., Doyle AG; Department of Chemistry, Princeton University, Princeton, NJ, USA. agdoyle@chem.ucla.edu.; Department of Chemistry and Biochemistry, University of California, Los Angeles, CA, USA. agdoyle@chem.ucla.edu.

Publikováno v: Nature [Nature] 2024 Feb; Vol. 626 (8001), pp. 1025-1033. Date of Electronic Publication: 2024 Feb 28.

Regioselective and Stereospecific Rhodium-Catalyzed Allylic Cyanomethylation with an Acetonitrile Equivalent: Construction of Acyclic β-Quaternary Stereogenic Nitriles.

Autor: Tom MJ; Department of Chemistry, Queen's University, 90 Bader Lane, Kingston ON K7L 3N6, Canada., Evans PA; Department of Chemistry, Queen's University, 90 Bader Lane, Kingston ON K7L 3N6, Canada.; Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, Hunan, P. R. of China.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2020 Jul 15; Vol. 142 (28), pp. 11957-11961. Date of Electronic Publication: 2020 Jul 02.