Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Tom M.A. Wilkinson"'
Publikováno v:
Heliyon, Vol 10, Iss 10, Pp e31201- (2024)
Background: Acute exacerbations of COPD (AECOPD) are episodes of breathlessness, cough and sputum which are associated with the risk of hospitalisation, progressive lung function decline and death. They are often missed or diagnosed late. Accurate ti
Externí odkaz:
https://doaj.org/article/cba9064e6938428cbe61235ecb1697f0
Autor:
Phillip D. Monk, Jody L. Brookes, Victoria J. Tear, Toby N. Batten, Marcin Mankowski, Tatjana Adzic-Vukicevic, Michael G. Crooks, Davinder P.S. Dosanjh, Monica Kraft, Christopher E. Brightling, Felicity J. Gabbay, Stephen T. Holgate, Ratko Djukanovic, Tom M.A. Wilkinson
Publikováno v:
ERJ Open Research, Vol 9, Iss 2 (2023)
Background Despite the availability of vaccines and therapies, patients are being hospitalised with coronavirus disease 2019 (COVID-19). Interferon (IFN)-β is a naturally occurring protein that stimulates host immune responses against most viruses,
Externí odkaz:
https://doaj.org/article/59ef7b2928b0495c936fac3cc3b5d606
Autor:
Ventzislava A. Hristova, Alastair Watson, Raghothama Chaerkady, Matthew S. Glover, Jodie Ackland, Bastian Angerman, Graham Belfield, Maria G. Belvisi, Hannah Burke, Doriana Cellura, Howard W. Clark, Damla Etal, Anna Freeman, Ashley I. Heinson, Sonja Hess, Michael Hühn, Emily Hall, Alex Mackay, Jens Madsen, Christopher McCrae, Daniel Muthas, Steven Novick, Kristoffer Ostridge, Lisa Öberg, Adam Platt, Anthony D. Postle, C. Mirella Spalluto, Outi Vaarala, Junmin Wang, Karl J. Staples, Tom M.A. Wilkinson, on behalf of the MICA II Study group
Publikováno v:
ERJ Open Research, Vol 9, Iss 3 (2022)
Rationale Pulmonary surfactant is vital for lung homeostasis as it reduces surface tension to prevent alveolar collapse and provides essential immune-regulatory and antipathogenic functions. Previous studies demonstrated dysregulation of some individ
Externí odkaz:
https://doaj.org/article/d0133b7993c74d2bbea08bf595e4130e
Autor:
Alastair Watson, Tom M.A. Wilkinson
Publikováno v:
Therapeutic Advances in Respiratory Disease, Vol 16 (2022)
Chronic obstructive pulmonary disease (COPD) remains a leading cause of morbidity and mortality despite current treatment strategies which focus on smoking cessation, pulmonary rehabilitation, and symptomatic relief. A focus of COPD care is to encour
Externí odkaz:
https://doaj.org/article/c51d5adb7ff945098ec235a17dfa014c
Autor:
Michael G. Crooks, Jack Elkes, William Storrar, Kay Roy, Mal North, Alison Blythin, Alastair Watson, Victoria Cornelius, Tom M.A. Wilkinson
Publikováno v:
ERJ Open Research, Vol 6, Iss 4 (2020)
Self-management interventions in COPD aim to improve patients' knowledge, skills and confidence to make correct decisions, thus improving health status and outcomes. myCOPD is a web-based self-management app known to improve inhaler use and exercise
Externí odkaz:
https://doaj.org/article/3a61e83916074b76b3aecf6158c43f7a
Publikováno v:
European Respiratory Review, Vol 29, Iss 156 (2020)
The prevalence of asthma remains high worldwide, with increasing awareness of the morbidity and mortality from asthma in low-income countries. In the UK, despite the development of biological treatments, many patients remain suboptimally controlled,
Externí odkaz:
https://doaj.org/article/424fc4802b4e43a6bdfefe5b59cbbd17
Autor:
Chia Wei Kong, Tom M.A. Wilkinson
Publikováno v:
ERJ Open Research, Vol 6, Iss 2 (2020)
More than a third of patients hospitalised for acute exacerbation of COPD are readmitted to hospital within 90 days. Healthcare professionals and service providers are expected to collaboratively drive efforts to improve hospital readmission rates, w
Externí odkaz:
https://doaj.org/article/b83bd6ca815244b2942def25b5515ebe
Autor:
Paul R. Newby, Diana Crossley, Helena Crisford, James A. Stockley, Richard A. Mumford, Richard I. Carter, Charlotte E. Bolton, Nicholas S. Hopkinson, Ravi Mahadeva, Michael C. Steiner, Tom M.A. Wilkinson, Elizabeth Sapey, Robert A. Stockley
Publikováno v:
ERJ Open Research, Vol 5, Iss 3 (2019)
α1-Antitrypsin (α1-AT) deficiency is a risk factor for emphysema due to tissue damage by serine proteases. Neutrophil elastase (NE) has long been considered the enzyme responsible. However, proteinase 3 (PR3) also produces the pathological features
Externí odkaz:
https://doaj.org/article/095479c2e89f446384bb49f27a617158
Autor:
Tom M.A. Wilkinson, Emmanuel Aris, Simon C. Bourne, Stuart C. Clarke, Mathieu Peeters, Thierry G. Pascal, Laura Taddei, Andrew C. Tuck, Viktoriya L. Kim, Kristoffer K. Ostridge, Karl J. Staples, Nicholas P. Williams, Anthony P. Williams, Stephen A. Wootton, Jeanne-Marie Devaster, The AERIS Study Group:, J. Alnajar, R. Anderson, E. Aris, W.R. Ballou, A. Barton, S. Bourne, M. Caubet, S.C. Clarke, D. Cleary, C. Cohet, N.A. Coombs, K. Cox, J-M. Devaster, V. Devine, N. Devos, E. Dineen, T. Elliott, R. Gladstone, S. Harden, J. Jefferies, V.L. Kim, P. Moris, K.K. Ostridge, T.G. Pascal, M. Peeters, B. Sente, S. Schoonbroodt, K.J. Staples, A.C. Tuck, L. Welch, V. Weynants, T.M.A. Wilkinson, A.P. Williams, N.P. Williams, C. Woelk, M. Wojtas, S.A. Wootton
Publikováno v:
ERJ Open Research, Vol 5, Iss 1 (2019)
The association between exacerbation aetiology and exacerbation frequency is poorly understood. We analysed 2-year follow-up data from a prospective observational study of patients with chronic obstructive pulmonary disease (COPD) (www.clinicaltrials
Externí odkaz:
https://doaj.org/article/540ca4bc52544e00b32d12c320a830b0
Autor:
Tom M.A. Wilkinson
Publikováno v:
European Respiratory Review, Vol 26, Iss 144 (2017)
Cell-mediated immune responses are vital to the body's defence against infection and play a key role in tumour immunity. T-cell activation and cytotoxic function is tightly regulated by a series of immune-regulatory receptor–ligand interactions or
Externí odkaz:
https://doaj.org/article/a4d37aac89f943bdb740bc6a5c2268c0