Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Tom M. McCaughtry"'
Autor:
Isharat Yusuf, Jessica Stern, Tom M McCaughtry, Sandra Gallagher, Hong Sun, Changshou Gao, Thomas Tedder, Gianluca Carlesso, Laura Carter, Ronald Herbst, Yue Wang
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e102791 (2014)
BACKGROUND: Continuous support from follicular CD4(+) T helper (Tfh) cells drives germinal center (GC) responses, which last for several weeks to produce high affinity memory B cells and plasma cells. In autoimmune Sle1 and NZB/W F1 mice, elevated nu
Externí odkaz:
https://doaj.org/article/14521c2dfb3045498d255b23c599e9dd
Autor:
Isharat Yusuf, Ronald Herbst, Tom M. McCaughtry, Roland Kolbeck, Hong Sun, Sean Turman, Yue Wang, Sandra Gallagher
Publikováno v:
Arthritis & Rheumatology. 68:965-976
Objective To evaluate treatment with MEDI-551, a humanized anti-human CD19 monoclonal antibody, in a model of autoimmunity involving mice transgenic (Tg) for Sle1 and human CD19 (hCD19). Methods Sle1.hCD19-Tg mice were given either a single intraveno
Autor:
Leonid A. Pobezinsky, Terry I. Guinter, Motoko Y. Kimura, Tejas Kadakia, Amala Alag, Alfred Singer, Ruth Etzensperger, Susanna Jeurling, Tom M. McCaughtry, Susan O. Sharrow, Lionel Feigenbaum
Publikováno v:
Nature immunology
Lethal-7 (let-7) microRNAs (miRNAs) are the most abundant miRNAs in the genome, but their role in developing thymocytes is unclear. We found that let-7 miRNAs targeted Zbtb16 mRNA, which encodes the lineage-specific transcription factor PLZF, to post
Autor:
Dinah S. Singer, Jie Mu, Terry I. Guinter, Motoko Y. Kimura, Ruth Etzensperger, Batu Erman, Lionel Feigenbaum, Gil Katz, Tom M. McCaughtry, Xuguang Tai, Alfred Singer, Amala Alag
Publikováno v:
Immunity. 38:1116-1128
SummaryImmune tolerance requires regulatory T (Treg) cells to prevent autoimmune disease, with the transcription factor Foxp3 functioning as the critical regulator of Treg cell development and function. We report here that Foxp3 was lethal to develop
Autor:
Tom M. McCaughtry, Alex Grinberg, Amala Alag, Alfred Singer, Lie Wang, Jung-Hyun Park, Rémy Bosselut, Motoko Y. Kimura, Xuguang Tai, François Van Laethem, Stanley Adoro, Batu Erman, Paul E. Love, Masato Kubo
Publikováno v:
The EMBO Journal. 31:366-377
Immature thymocytes are bipotential cells that are signalled during positive selection to become either helper- or cytotoxic-lineage T cells. By tracking expression of lineage determining transcription factors during positive selection, we now report
Publikováno v:
The Journal of Experimental Medicine
The thymic medulla is generally held to be a specialized environment for negative selection. However, many self-reactive thymocytes first encounter ubiquitous self-antigens in the cortex. Cortical epithelial cells are vital for positive selection, bu
Publikováno v:
The Journal of Experimental Medicine
Conventional alphabeta T cell precursors undergo positive selection in the thymic cortex. When this is successful, they migrate to the medulla and are exposed to tissue-specific antigens (TSA) for purposes of central tolerance, and they undergo matur
Autor:
Sandra, Gallagher, Isharat, Yusuf, Tom M, McCaughtry, Sean, Turman, Hong, Sun, Roland, Kolbeck, Ronald, Herbst, Yue, Wang
Publikováno v:
Arthritisrheumatology (Hoboken, N.J.). 68(4)
To evaluate treatment with MEDI-551, a humanized anti-human CD19 monoclonal antibody, in a model of autoimmunity involving mice transgenic (Tg) for Sle1 and human CD19 (hCD19).Sle1.hCD19-Tg mice were given either a single intravenous dose of MEDI-551
Autor:
Yue Wang, Ronald Herbst, Jessica Stern, Tom M. McCaughtry, Hong Sun, Thomas F. Tedder, Isharat Yusuf, Gianluca Carlesso, Sandra Gallagher, Laura Carter, Changshou Gao
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 8, p e102791 (2014)
PLoS ONE, Vol 9, Iss 8, p e102791 (2014)
Background Continuous support from follicular CD4+ T helper (Tfh) cells drives germinal center (GC) responses, which last for several weeks to produce high affinity memory B cells and plasma cells. In autoimmune Sle1 and NZB/W F1 mice, elevated numbe
Autor:
Paul E. Love, Sema Kurtulus, Batu Erman, Alex Grinberg, Amala Alag, Alfred Singer, Jung-Hyun Park, Ruth Etzensperger, Tom M. McCaughtry, Lionel Feigenbaum, Xuguang Tai
Publikováno v:
The Journal of Experimental Medicine
Two cytokines that signal through the common gamma chain receptor, IL-7 and IL-15, are responsible for the differentiation of developing thymocytes into CD8+ cytotoxic lineage T cells in mice.
The thymus generates T cells with diverse specificit
The thymus generates T cells with diverse specificit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78cc51a5921f4e6ad26b7e934418d177