Výsledky vyhledávání - "Tom M. J. Evers"

Akademický článek

Single‐Cell Mechanical Characterization of Human Macrophages

Autor: Tom M. J. Evers, Vahid Sheikhhassani, Huaqi Tang, Mariëlle C. Haks, Tom H. M. Ottenhoff, Alireza Mashaghi

Publikováno v: Advanced NanoBiomed Research, Vol 2, Iss 7, Pp n/a-n/a (2022)

Macrophages remodel their mechanics during differentiation toward different subtypes and drastically adapt their shapes during phagocytosis or entry to inflamed tissues. Although these functions depend on cell mechanical properties, the mechanical be

Externí odkaz: https://doaj.org/article/930b88d253634c20b357262eea378044

Zobrazit plný text záznamu

Reciprocal regulation of cellular mechanics and metabolism

Autor: Alireza Mashaghi, Tom M J Evers, Liam J. Holt, Simon Alberti

Publikováno v: Nat Metab

Metabolism and mechanics are intrinsically intertwined. External forces, sensed through the cytoskeleton or distortion of the cell and organelles, induce metabolic changes in the cell. The resulting changes in metabolism, in turn, feed back to regula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f72ecb4f9a58693f86c2dd0d2c09a9d
https://doi.org/10.1038/s42255-021-00384-w

Zobrazit plný text záznamu

Topological dynamics of an intrinsically disordered N-terminal domain of the human androgen receptor

Autor: Vahid Sheikhhassani, Barbara Scalvini, Julian Ng, Laurens W. H. J. Heling, Yosri Ayache, Tom M. J. Evers, Eva Estébanez‐Perpiñá, Iain J. McEwan, Alireza Mashaghi

Publikováno v: Protein Science, 31(6):e4334. Wiley

Human androgen receptor contains a large N-terminal domain (AR-NTD) that is highly dynamic and this poses a major challenge for experimental and computational analysis to decipher its conformation. Misfolding of the AR-NTD is implicated in prostate c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9c89a039bd6914154a12ad0b2111eac
https://pubmed.ncbi.nlm.nih.gov/35634773

Zobrazit plný text záznamu

Single cell force spectroscopy of erythrocytes at physiological and febrile temperatures reveals mechano-modulatory effects of atorvastatin

Autor: Vahid Sheikhhassani, Tom M. J. Evers, Sanjeevani Lamba, Fereshteh Shokri, Alireza Mashaghi

Publikováno v: Soft matter. 18(11)

RBCs are mechanically active cells and constantly deform as they circulate through vasculature. Their mechanical properties can be significantly altered by various pathophysiological conditions, and the alterations in RBC mechanics can, in turn, have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecce29c5f76f21aa265e2d6df7e6e841
https://pubmed.ncbi.nlm.nih.gov/35201243

Zobrazit plný text záznamu

Single-cell analysis reveals chemokine-mediated differential regulation of monocyte mechanics

Autor: Cornelis Storm, Tom M J Evers, Alireza Mashaghi, Vahid Sheikhhassani, Tom H. M. Ottenhoff, Mariëlle C. Haks

Publikováno v: iScience, Vol 25, Iss 1, Pp 103555-(2022)
iScience
iScience, 25(1). CELL PRESS
iScience, 25(1):103555. Cell Press

Summary Monocytes continuously adapt their shapes for proper circulation and elicitation of effective immune responses. Although these functions depend on the cell mechanical properties, the mechanical behavior of monocytes is still poorly understood

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c074f8bd09304d82dd26ba179fb8a61
https://hdl.handle.net/1887/3303604

Zobrazit plný text záznamu

ADCC-Inducing Antibody Trastuzumab and Selection of KIR-HLA Ligand Mismatched Donors Enhance the NK Cell Anti-Breast Cancer Response

Autor: Femke A I Ehlers, Nicky A. Beelen, Lotte Wieten, Tom M J Evers, Michel van Gelder, Gerard M. J. Bos, Loes F. S. Kooreman, Marjolein L. Smidt

Publikováno v: Cancers
Volume 13
Issue 13
Cancers, 13(13):3232. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers, Vol 13, Iss 3232, p 3232 (2021)

Simple Summary Natural killer (NK) cells are potent killers of tumor cells. Many tumors, including breast cancers, develop mechanisms to suppress anti-tumor immune responses, requiring the development of strategies to overcome suppression. Here, we t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcc1a5315adf4a79a1b13c86449fbe52
https://doi.org/10.3390/cancers13133232

Zobrazit plný text záznamu

Plný text ve formátu HTML

Deciphering Metabolic Heterogeneity by Single-Cell Analysis

Autor: Mazène Hochane, Stefan Semrau, Ron M. A. Heeren, Alireza Mashaghi, Peter Nemes, Sander J. Tans, Tom M J Evers

Publikováno v: Anal Chem
Analytical Chemistry, 91(21), 13314-13323. American Chemical Society

Single-cell analysis provides insights into cellular heterogeneity and dynamics of individual cells. This feature highlights recent developments in key analytical techniques suited for single-cell metabolic analysis with a special focus on mass spect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0664fd30d9c7cdd4e2a3967ea444d80e
https://doi.org/10.1021/acs.analchem.9b02410

Zobrazit plný text záznamu

Publisher Correction: Reciprocal regulation of cellular mechanics and metabolism

Autor: Simon Alberti, Alireza Mashaghi, Liam J. Holt, Tom M J Evers

Publikováno v: Nature Metabolism. 3:876-877

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::89512e56420ba2375da6a08671a11cea
https://doi.org/10.1038/s42255-021-00423-6

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání