Zobrazeno 1 - 10
of 241
pro vyhledávání: '"Tom L Broderick"'
Autor:
Janelle Lopez, Layla Al-Nakkash, Tom L. Broderick, Monica Castro, Brielle Tobin, Jeffrey H. Plochocki
Publikováno v:
Metabolites, Vol 13, Iss 9, p 1014 (2023)
Type 2 diabetes mellitus and osteoarthritis (OA) often present as comorbidities. We examined the role of plasma IL-6, chondrocyte MMP-13, and col10a expression in the development of OA in obese diabetic mice. We further investigated dietary genistein
Externí odkaz:
https://doaj.org/article/4cebb495794d4b3889b9e136edb7af9e
Publikováno v:
Metabolites, Vol 13, Iss 3, p 438 (2023)
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder associated with cognitive decline and characterized by amyloid-β plaques and neurofibrillary tau tangles. Although AD’s exact pathophysiology remains unclear, oxidative stress
Externí odkaz:
https://doaj.org/article/d4489dadd5524686bfd55cd9d684e20a
Autor:
Mustafa F. Alkhouli, Jun Hung, Michaela Squire, Miranda Anderson, Monica Castro, Jeganathan R. Babu, Layla Al-Nakkash, Tom L. Broderick, Jeffrey H. Plochocki
Publikováno v:
BMC Complementary and Alternative Medicine, Vol 19, Iss 1, Pp 1-7 (2019)
Abstract Background Alzheimer’s disease (AD) and osteoporosis are progressive diseases that affect the elderly population. Both conditions are associated with fracture risk that is greater than twice that of the healthy population. Resveratrol and
Externí odkaz:
https://doaj.org/article/7dfb245984ec4ecb8f6934fe2f452cce
Publikováno v:
Diabetology & Metabolic Syndrome, Vol 11, Iss 1, Pp 1-5 (2019)
Abstract Background Leptin is an adipokine that regulates energy homeostasis and is also needed for normal bone growth and maintenance. Mutation in the lep gene, which characterizes the ob/ob mouse model, results in the development of obesity and typ
Externí odkaz:
https://doaj.org/article/67c4fb1da05449238b1a601e0421de8d
Publikováno v:
Frontiers in Psychology, Vol 11 (2020)
The beneficial effects of oxytocin on infarct size and functional recovery of the ischemic reperfused heart are well documented. The mechanisms for this cardioprotection are not well defined. Evidence indicates that oxytocin treatment improves cardia
Externí odkaz:
https://doaj.org/article/9bb5c602a4d44bc881e1fbc70afc72d5
Autor:
Levi Buchan, Chaheyla R. St. Aubin, Amy L. Fisher, Austin Hellings, Monica Castro, Layla Al-Nakkash, Tom L. Broderick, Jeffrey H. Plochocki
Publikováno v:
BMC Research Notes, Vol 11, Iss 1, Pp 1-6 (2018)
Abstract Objective We tested the effect of exercise training and genistein treatment on splenomegaly in mice fed a high-fat, high-sugar diet (HFSD). Results Male and female C57BL6 mice fed HFSD containing 60% fat along with drinking water containing
Externí odkaz:
https://doaj.org/article/682aaeac7e32430c9a7b9d912a7849ba
Publikováno v:
Molecules, Vol 26, Iss 22, p 6872 (2021)
Carnitine insufficiency is reported in type 1 diabetes mellitus. To determine whether this is accompanied by defects in biosynthesis and/or renal uptake, liver and kidney were obtained from male Sprague-Dawley rats with streptozotocin-induced diabete
Externí odkaz:
https://doaj.org/article/aadbde9767c846b08b8b2a0e8cf5e801
Publikováno v:
Kidney & Blood Pressure Research, Vol 42, Iss 3, Pp 398-405 (2017)
Background/Aims: Carnitine is essential for the transport of long-chain FAs (FA) into the mitochondria for energy production. During acute exercise, the increased demand for FAs results in a state of free carnitine deficiency in plasma. The role of k
Externí odkaz:
https://doaj.org/article/7cd702459cfb469e997686c8252439e1
Autor:
Marek Jankowski, Bogdan A Danalache, Eric Plante, Ahmed Menaouar, Maria Florian, Ju Jing Tan, Ryszard Grygorczyk, Tom L Broderick, Jolanta Gutkowska
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0219205 (2019)
In the rat, oxytocin (OT) produces dose-dependent diuretic and natriuretic responses. Post-translational enzymatic conversion of the OT biosynthetic precursor forms both mature and C-terminally extended peptides. The plasma concentrations of these C-
Externí odkaz:
https://doaj.org/article/e514b943d6284392a20e364c2c53b396
Publikováno v:
Molecules, Vol 25, Iss 9, p 2100 (2020)
(1) Background: Diet-induced obesity inhibits hepatic carnitine biosynthesis. Herein, the effects of high-fat (HF) and high-sugar (HFHS) feeding and exercise training (ET) on renal carnitine biosynthesis and uptake were determined. (2) Methods: Male
Externí odkaz:
https://doaj.org/article/43326b5476ef4f30803fbf6cb2e123cb