Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Tom Januario"'
Autor:
Jennifer Cantley, Xiaofen Ye, Emma Rousseau, Tom Januario, Brian D. Hamman, Christopher M. Rose, Tommy K. Cheung, Trent Hinkle, Leofal Soto, Connor Quinn, Alicia Harbin, Elizabeth Bortolon, Xin Chen, Roy Haskell, Eva Lin, Shang-Fan Yu, Geoff Del Rosario, Emily Chan, Debra Dunlap, Hartmut Koeppen, Scott Martin, Mark Merchant, Matt Grimmer, Fabio Broccatelli, Jing Wang, Jennifer Pizzano, Peter S. Dragovich, Michael Berlin, Robert L. Yauch
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
SMARCA2 has been identified as a synthetic lethal target in SMARCA4 mutated tumors, however, homology between the two has hindered the development of selective SMARCA2 inhibitors. Here, the authors synthesize a proteolysis targeting chimera (PROTAC)
Externí odkaz:
https://doaj.org/article/8a0e9dc628914f238a2a801adba2571a
Autor:
David S. Shames, Juliet Carbon, Kim Walter, Adrian M. Jubb, Cleopatra Kozlowski, Tom Januario, An Do, Ling Fu, Yuanyuan Xiao, Rajiv Raja, Brittany Jiang, Ashi Malekafzali, Howard Stern, Jeff Settleman, Timothy R. Wilson, Garret M. Hampton, Robert L. Yauch, Andrea Pirzkall, Lukas C. Amler
Publikováno v:
PLoS ONE, Vol 8, Iss 6 (2013)
Externí odkaz:
https://doaj.org/article/da2dd6cdef20483ba695c61154d0167a
Autor:
David S Shames, Juliet Carbon, Kim Walter, Adrian M Jubb, Cleopatra Kozlowski, Tom Januario, An Do, Ling Fu, Yuanyuan Xiao, Rajiv Raja, Brittany Jiang, Ashi Malekafzali, Howard Stern, Jeff Settleman, Timothy R Wilson, Garret M Hampton, Robert L Yauch, Andrea Pirzkall, Lukas C Amler
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56765 (2013)
PURPOSE:Tumors with oncogenic dependencies on the HER family of receptor tyrosine kinases (RTKs) often respond well to targeted inhibition. Our previous work suggested that many cell lines derived from squamous cell carcinomas of the head and neck (S
Externí odkaz:
https://doaj.org/article/5cf55f2aa8554020b93f2ed9634c7bd4
Autor:
Stephen E. Gould, Frederic J. de Sauvage, Robert L. Yauch, Tom Januario, Hank La, Patricia Pacheco, Kristina A. West, Bruno Alicke, Harvey Wong
PDF file - 64K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a94d3e334ec0722a175a9109310ce0
https://doi.org/10.1158/1078-0432.22442118
https://doi.org/10.1158/1078-0432.22442118
Autor:
Robert L. Yauch, Amy Peterson, Premal Patel, See-Chun Phan, Lukas Amler, Vanitha Ramakrishnan, Mirella Lazarov, Jenny Huang, Marina Lipkind, Ignacio Wistuba, David S. Shames, Ellen Filvaroff, Sharianne G. Louie, Tom Januario, Xiaoling Xia, Vaishali Parab, An Do, Ling Fu, Rupal Desai, Rajesh Patel, Sankar Mohan, Rajiv Raja, Linda Rangell, Elicia Penuel, Ajay Pandita, Jiping Zha, Wei Yu, Hartmut Koeppen
Figure S1. Characterization of SP44 specificity; Figure S2. Relationship of IHC intensity with FACS; Figure S3. Relationship of IHC intensity with mRNA; Figure S4. Representative IHC images; Figure S5 and S6. MET IHC H-scores; Figure S7. Relationship
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f30d3401a7f695ff0b6715b48881b37
https://doi.org/10.1158/1078-0432.22447172
https://doi.org/10.1158/1078-0432.22447172
Autor:
Robert L. Yauch, Amy Peterson, Premal Patel, See-Chun Phan, Lukas Amler, Vanitha Ramakrishnan, Mirella Lazarov, Jenny Huang, Marina Lipkind, Ignacio Wistuba, David S. Shames, Ellen Filvaroff, Sharianne G. Louie, Tom Januario, Xiaoling Xia, Vaishali Parab, An Do, Ling Fu, Rupal Desai, Rajesh Patel, Sankar Mohan, Rajiv Raja, Linda Rangell, Elicia Penuel, Ajay Pandita, Jiping Zha, Wei Yu, Hartmut Koeppen
Table S1. Overlap of biomarkers measured in OAM4558g; Table S2. Primer/probe information; Table S3. MET diagnostic scoring criteria; Table S4. MET IHC intratumoral heterogeneity; Table S5. Impact of KRAS/EGFR mutation on clinical outcome; Table S6. B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bc7e6eceddf0949632b7768ff664e20
https://doi.org/10.1158/1078-0432.22447166
https://doi.org/10.1158/1078-0432.22447166
Autor:
David S. Shames, Robert L. Yauch, Richard Bourgon, Lukas C. Amler, Garret M. Hampton, Somasekar Seshagiri, Zora Modrusan, Howard Stern, Ling Huw, Robert Soriano, Leonardo Iniguez, Nithya Kartha, Marie Evangelista, Pan Du, Tom Januario, Thomas Holcomb, Kim Walter
Purpose: Non–small cell lung cancers (NSCLC) comprise multiple distinct biologic groups with different prognoses. For example, patients with epithelial-like tumors have a better prognosis and exhibit greater sensitivity to inhibitors of the epiderm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14ce41ba405cf8dca77e1264fa33a7c8
https://doi.org/10.1158/1078-0432.c.6520001
https://doi.org/10.1158/1078-0432.c.6520001
Autor:
Mark R. Lackner, Lori S. Friedman, Marcia Belvin, Lukas Amler, Lesley Murray, Leanne Berry, Wei Zhou, Tom Truong, Elizabeth Punnoose, Heidi Savage, Tom Januario, Kenneth Jung, Steve Guerrero, Guy Cavet, Zachary Boyd, Carol O'Brien, Klaus P. Hoeflich
Purpose: The pathways underlying basal-like breast cancer are poorly understood, and as yet, there is no approved targeted therapy for this disease. We investigated the role of mitogen-activated protein kinase kinase (MEK) and phosphatidylinositol 3-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93b168ddd5fe9feef9198511f1a99af2
https://doi.org/10.1158/1078-0432.c.6517446.v1
https://doi.org/10.1158/1078-0432.c.6517446.v1
Autor:
David S. Shames, Robert L. Yauch, Richard Bourgon, Lukas C. Amler, Garret M. Hampton, Somasekar Seshagiri, Zora Modrusan, Howard Stern, Ling Huw, Robert Soriano, Leonardo Iniguez, Nithya Kartha, Marie Evangelista, Pan Du, Tom Januario, Thomas Holcomb, Kim Walter
PDF file - 1.8MB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9475f73ba3c38236adf386ed5b9ec970
https://doi.org/10.1158/1078-0432.22443884.v1
https://doi.org/10.1158/1078-0432.22443884.v1
Autor:
Mark R. Lackner, Lori S. Friedman, Marcia Belvin, Lukas Amler, Lesley Murray, Leanne Berry, Wei Zhou, Tom Truong, Elizabeth Punnoose, Heidi Savage, Tom Januario, Kenneth Jung, Steve Guerrero, Guy Cavet, Zachary Boyd, Carol O'Brien, Klaus P. Hoeflich
Supplementary Data from In vivo Antitumor Activity of MEK and Phosphatidylinositol 3-Kinase Inhibitors in Basal-Like Breast Cancer Models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88dbb088331655cbbdf912262e9aeb6c
https://doi.org/10.1158/1078-0432.22440072.v1
https://doi.org/10.1158/1078-0432.22440072.v1