Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Tom J.C. Ruigrok"'
Autor:
Tom J.C. Ruigrok, Cees W. A. van de Kolk, Marcel G.J. Nederhoff, Cees J. A. van Echteld, George J Brandon Bravo Bruinsma, Johan J. Bredée
Publikováno v:
The Journal of Heart and Lung Transplantation. 20:996-1004
Background and Objective: Recently, we have shown, by using localized in vivo phosphorus-31 magnetic resonance spectroscopy (31P MRS) of the anterior left ventricular wall, that brain death (BD) is not associated with reduced myocardial energy status
Publikováno v:
Molecular and Cellular Biochemistry. 203:169-175
Reperfusion of isolated mammalian hearts with a Ca2+-containing solution after a short Ca2+-free period at 37°:C results in massive influx of Ca2+ into the cells and irreversible cell damage: the Ca2+paradox. Information about the free intracellular
Autor:
George J Brandon Bravo Bruinsma, Tom J.C. Ruigrok, Cees J. A. van Echteld, Cees W. A. van de Kolk, Marcel G.J. Nederhoff, Mark C.H. De Groot, Johan J. Bredée, Piet J. Slootweg
Publikováno v:
The Journal of Heart and Lung Transplantation. 18:1189-1197
Objective: Long-term exposure of the donor heart to high dosages of dopamine in the treatment of brain death–related hemodynamic deterioration has been shown to reduce myocardial phosphocreatine (PCr) and adenosine triphosphate (ATP) in myocardial
Publikováno v:
Journal of Molecular and Cellular Cardiology. 30:119-126
23Na and 31P NMR spectroscopy were used to follow intracellular [Na+] ([Na+]i) and energy metabolism in isolated, perfused rat hearts. During 30 min of Ca(2+)-free perfusion no significant change in [Na+]i could be detected, but during a subsequent 4
Autor:
Anna Cargnoni, Salvatore Curello, Claudio Ceconi, Palmira Bernocchi, Roberto Ferrari, Tom J.C. Ruigrok, Evasio Pasini
Publikováno v:
Circulation. 94:2587-2596
Background Myocardial hibernation is an adaptive phenomenon occurring in patients with a history of acute ischemia followed by prolonged hypoperfusion. Methods and Results We investigated, in isolated rabbit heart, whether a brief episode of global i
Publikováno v:
Journal of Molecular and Cellular Cardiology. 23:297-307
Accumulation of sodium-ions (Na + ) in myocardial cells during both ischemia and calcium (Ca 2+ )-free perfusion has been suggested to play an important role in the damage occurring during subsequent reperfusion and calcium repletion, respectively. W
Autor:
Q. G. C. M. van Hoesel, W. H. de Jong, C. J. A. van Echteld, Tom J.C. Ruigrok, J.H. Kirkels, J. H. Schornagel, T. Dekker
Publikováno v:
NMR in Biomedicine. 4:16-24
Adriamycin induced cardiotoxicity is, among other factors, characterized by an impairment of mitochondrial function and altered energy metabolism. The possible merits of 31P NMR in timely detection of this cardiotoxicity were studied in perfused hear
Publikováno v:
Magma (New York, N.Y.). 11(1-2)
Autor:
C.J.A. van Echteld, Tom J.C. Ruigrok
Publikováno v:
Journal of Molecular and Cellular Cardiology. 23:769-771
Publikováno v:
Pflugers Archiv : European journal of physiology. 436(4)
Ca2+ paradox damage has been suggested to be determined by Na+ entry during Ca2+ depletion and exchange of Na+ for Ca2+ during Ca2+ repletion. Since previously a Ca2+ paradox without prior increase of total intracellular [Na+] ([Na+]i) has been obser