Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Tom J. Carney"'
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 5 (2024)
Externí odkaz:
https://doaj.org/article/d8a23f4621ff43f7ba7edc54c7ca2a75
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 9 (2020)
Heterotopic ossification (HO) is a disorder characterised by the formation of ectopic bone in soft tissue. Acquired HO typically occurs in response to trauma and is relatively common, yet its aetiology remains poorly understood. Genetic forms, by con
Externí odkaz:
https://doaj.org/article/c18ded1682ef4a099fcf376fd0d7cbea
Publikováno v:
Disease Models & Mechanisms, Vol 12, Iss 9 (2019)
Reduced bone quality or mineral density predict susceptibility to fracture and also attenuate subsequent repair. Bone regrowth is also compromised by bacterial infection, which exacerbates fracture site inflammation. Because of the cellular complexit
Externí odkaz:
https://doaj.org/article/be2871490c584ddcaf613790f841781e
Autor:
Katherine S Marsay, Sarah Greaves, Harsha Mahabaleshwar, Charmaine Min Ho, Henry Roehl, Peter N Monk, Tom J Carney, Lynda J Partridge
Publikováno v:
PLoS ONE, Vol 16, Iss 11, p e0260372 (2021)
Collective cell migration is essential for embryonic development and homeostatic processes. During zebrafish development, the posterior lateral line primordium (pLLP) navigates along the embryo flank by collective cell migration. The chemokine recept
Externí odkaz:
https://doaj.org/article/5bd127ea37cd444abb64e1112e5a5886
Publikováno v:
Scott, C A, Carney, T J & Amaya, E 2022, ' Aerobic glycolysis is important for zebrafish larval wound closure and tail regeneration ', Wound Repair and Regeneration . https://doi.org/10.1111/wrr.13050
The underlying mechanisms of appendage regeneration remain largely unknown and uncovering these mechanisms in capable organisms has far-reaching implications for potential treatments in humans. Recent studies implicate a requirement for metabolic rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::424322a3c50f4c26ccce43e2eecab4f2
https://doi.org/10.1111/wrr.13050
https://doi.org/10.1111/wrr.13050
Autor:
Keh-Weei Tzung, Robert L. Lalonde, Karin D. Prummel, Harsha Mahabaleshwar, Hannah R. Moran, Jan Stundl, Amanda N. Cass, Yao Le, Robert Lea, Karel Dorey, Monika J. Tomecka, Changqing Zhang, Eline C. Brombacher, William T. White, Henry H. Roehl, Frank J. Tulenko, Christoph Winkler, Peter D. Currie, Enrique Amaya, Marcus C. Davis, Marianne E. Bronner, Christian Mosimann, Tom J. Carney
Publikováno v:
Nature.
The development of paired appendages was a key innovation during evolution and facilitated the aquatic to terrestrial transition of vertebrates. Largely derived from the lateral plate mesoderm (LPM), one hypothesis for the evolution of paired fins in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::467e218457f50e8ddc9901c2866d6cfb
https://doi.org/10.1038/s41586-023-06100-w
https://doi.org/10.1038/s41586-023-06100-w
Autor:
Harsha Mahabaleshwar, PV Asharani, Tricia Yi Loo, Shze Yung Koh, Melissa R Pitman, Samuel Kwok, Jiajia Ma, Bo Hu, Fang Lin, Xue Li Lok, Stuart M Pitson, Timothy E Saunders, Tom J Carney
Publikováno v:
EMBO Rep
Immigration of mesenchymal cells into the growing fin and limb buds drives distal outgrowth, with subsequent tensile forces between these cells essential for fin and limb morphogenesis. Morphogens derived from the apical domain of the fin, orientate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0da3d15f5b3c9f81e0c200f2e8c56e53
https://pubmed.ncbi.nlm.nih.gov/35679135
https://pubmed.ncbi.nlm.nih.gov/35679135
Autor:
Harsha Mahabaleshwar, P.V. Asharani, Tricia Loo Yi Jun, Shze Yung Koh, Melissa R. Pitman, Samuel Kwok, Jiajia Ma, Bo Hu, Fang Lin, Xue Li Lok, Stuart M. Pitson, Timothy E. Saunders, Tom J. Carney
SUMMARYImmigration of mesenchymal cells into the growing fin and limb buds drives distal outgrowth, with subsequent tensile forces between these cells essential for fin and limb morphogenesis. Morphogens derived from the apical domain of the fin, ori
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9bf2a0f428add986485656b4fb9176e5
https://doi.org/10.1101/2021.12.07.471519
https://doi.org/10.1101/2021.12.07.471519
Editor's Highlight: Transgenic Zebrafish Reporter Lines as Alternative In Vivo Organ Toxicity Models
Autor:
Kar Lai, Poon, Xingang, Wang, Serene G P, Lee, Ashley S, Ng, Wei Huang, Goh, Zhonghua, Zhao, Muthafar, Al-Haddawi, Haishan, Wang, Sinnakaruppan, Mathavan, Philip W, Ingham, Claudia, McGinnis, Tom J, Carney
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 156(1)
Organ toxicity, particularly liver toxicity, remains one of the major reasons for the termination of drug candidates in the development pipeline as well as withdrawal or restrictions of marketed drugs. A screening-amenable alternative in vivo model s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::78ad8241b8ee62d14aea6109580f2155
https://pubmed.ncbi.nlm.nih.gov/28069987
https://pubmed.ncbi.nlm.nih.gov/28069987
Autor:
Jiajia Ma, Claire A Scott, Ying Na Ho, Harsha Mahabaleshwar, Katherine S Marsay, Changqing Zhang, Christopher KJ Teow, Ser Sue Ng, Weibin Zhang, Vinay Tergaonkar, Lynda J Partridge, Sudipto Roy, Enrique Amaya, Tom J Carney
Publikováno v:
eLife, Vol 10 (2021)
Epithelial tissues are primed to respond to insults by activating epithelial cell motility and rapid inflammation. Such responses are also elicited upon overexpression of the membrane-bound protease, Matriptase, or mutation of its inhibitor, Hai1. Un
Externí odkaz:
https://doaj.org/article/380d55289a8f47f281a3eaefddfb6c5e