Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Tom J Burke"'
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39596 (2012)
Y-family DNA-polymerases have larger active sites that can accommodate bulky DNA adducts allowing them to bypass these lesions during replication. One member, polymerase eta (pol eta), is specialized for the bypass of UV-induced thymidine-thymidine d
Externí odkaz:
https://doaj.org/article/1a48da194ab641dab5e8a7eda2f340b7
Autor:
Timothy L. Wiemken, Andrea Reyes Vega, Jeffrey D. Ritzenthaler, Jesse Roman, Yuxuan Zheng, Stephen Furmanek, Walter H. Watson, Tom J. Burke, Paula Peyrani, Julio A. Ramirez
Publikováno v:
Free Radic Biol Med
Chronic obstructive pulmonary disease (COPD) is prevalent in patients infected with HIV. The purpose of this study was to test the hypothesis that systemic oxidation correlates with loss of lung function in subjects with COPD, and that HIV infection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0004c33134cb1a76e1502ec4c02c24a
https://doi.org/10.1016/j.freeradbiomed.2019.07.031
https://doi.org/10.1016/j.freeradbiomed.2019.07.031
Autor:
Jeffrey D. Ritzenthaler, Yuxuan Zheng, Tom J. Burke, Michael L. Merchant, Walter H. Watson, Ming Li, Frederick W. Benz, Adam E. Gaweda, Jesse Roman
Publikováno v:
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2020 (2020)
Oxidative Medicine and Cellular Longevity, Vol 2020 (2020)
Slc7a11 is the key component of system Xc-, an antiporter that imports cystine (CySS) and exports glutamate. It plays an important role in cellular defense against oxidative stress because cysteine (Cys), reduced from CySS, is used for and limits the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0394e5c3e96878c30f8175f94866d10
http://europepmc.org/articles/PMC7298344
http://europepmc.org/articles/PMC7298344
Autor:
Jesse Roman, Jeffrey D. Ritzenthaler, Tom J. Burke, Yuxuan Zheng, Walter H. Watson, Javier Otero
Publikováno v:
Free Radical Biology and Medicine. 118:13-22
Aging is associated with progressive oxidation of the extracellular environment. The redox state of human plasma, defined by the concentrations of cysteine (Cys) and cystine (CySS), becomes more oxidized as we age. Recently, we showed that fibroblast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96056045ad2527496ad312f09387f6c3
https://doi.org/10.1016/j.freeradbiomed.2018.02.026
https://doi.org/10.1016/j.freeradbiomed.2018.02.026
Publikováno v:
Alcoholism: Clinical and Experimental Research. 38:889-896
Background Chronic alcohol exposure results in liver injury that is driven in part by inflammatory cytokines such as tumor necrosis factor-α (TNF). Hepatocytes are normally resistant to the cytotoxic effects of TNF, but they become sensitized to TNF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::389deaa02e512a0593372bfc94669026
https://doi.org/10.1111/acer.12315
https://doi.org/10.1111/acer.12315
Autor:
Jeffrey D. Ritzenthaler, Igor N. Zelko, Walter H. Watson, Tom J. Burke, Edilson Torres-Gonzalez, Jesse Roman
Publikováno v:
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2016 (2016)
Oxidative Medicine and Cellular Longevity, Vol 2016 (2016)
Aging is associated with progressive oxidation of plasma cysteine (Cys)/cystine (CySS) redox state, expressed asEhCySS. Cultured cells condition their media to reproduce physiologicalEhCySS, but it is unknown whether aged cells produce a more oxidize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59d33637585b0f86cb58657d25d03f57
https://pubmed.ncbi.nlm.nih.gov/27642492
https://pubmed.ncbi.nlm.nih.gov/27642492
Autor:
John W. Eaton, D.R. Clark, W.G. McGregor, Xueshan Gao, Jian Campian, Mingwei Qian, Tom J. Burke
Publikováno v:
Free Radical Biology and Medicine. 40:165-172
Tobacco smoke contains substances capable of binding iron in an aqueous medium and transferring the metal into both organic solvents and intact mammalian red cells. This iron-binding activity is due to free fatty acids which are abundant in tobacco s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60634dbf527b22dde017121408fdbca9
https://doi.org/10.1016/j.freeradbiomed.2005.09.033
https://doi.org/10.1016/j.freeradbiomed.2005.09.033
Autor:
John O. Trent, Shelia D. Thomas, Fofi Hamhouyia, Donald M. Miller, Tom J. Burke, W. Glenn McGregor, Paula J. Bates, Allicia C. Girvan, Xiaohua Xu
Publikováno v:
Journal of Biological Chemistry. 276:43221-43230
The discovery of G-rich oligonucleotides (GROs) that have non-antisense antiproliferative activity against a number of cancer cell lines has been recently described. This biological activity of GROs was found to be associated with their ability to fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c11e6ef781ac512637d19750732016b
https://doi.org/10.1074/jbc.m104446200
https://doi.org/10.1074/jbc.m104446200
Publikováno v:
Free radical biologymedicine. 51(8)
The redox-sensitive transcription factor NFκB mediates the expression of genes involved in inflammation and cell survival. Thioredoxin reductase-1 (TR1) and its substrate thioredoxin-1 (Trx1) act together to reduce oxidized cysteine residues within
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f46cc47769c243048e08b5afe85bec4
https://pubmed.ncbi.nlm.nih.gov/21782934
https://pubmed.ncbi.nlm.nih.gov/21782934
Publikováno v:
Nucleic Acids Research
Comparative mutagenesis of 1,N(6)-ethenoadenine (epsilonA) and 8-oxoguanine (8-oxoG), two endogenous DNA lesions that are also formed by exogenous DNA damaging agents, have been evaluated in HeLa and xeroderma pigmentosum variant (XPV) cell extracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17f2527eb008d73307f88cdaba0f4f0b
https://pubmed.ncbi.nlm.nih.gov/18184697
https://pubmed.ncbi.nlm.nih.gov/18184697