Zobrazeno 1 - 10 of 63 pro vyhledávání: '"Tom Huang"'
1
CD47-blocking Antibody ZL-1201 Promotes Tumor-associated Macrophage Phagocytic Activity and Enhances the Efficacy of the Therapeutic Antibodies and Chemotherapy
Autor: Anthony Cao, Jiaqing Yi, Xinyan Tang, Christopher W. Szeto, Renyi Wu, Bing Wan, Xu Fang, Shou Li, Lei Wang, Lina Wang, Jing Li, Qiuping Ye, Tom Huang, Karl Hsu, Omar Kabbarah, Haiying Zhou
Publikováno v: Cancer Research Communications. 2:1404-1417
Tumor-associated macrophages (TAM) are the most abundant immune cells in the tumor microenvironment. They consist of various subsets but primarily resemble the M2 macrophage phenotype. TAMs are known to promote tumor progression and are associated wi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5638f5901214f51c0b5f5f101221268a
https://doi.org/10.1158/2767-9764.crc-22-0266
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2
ZL-1211 Exhibits Robust Antitumor Activity by Enhancing ADCC and Activating NK Cell–mediated Inflammation in CLDN18.2-High and -Low Expressing Gastric Cancer Models
Autor: Hiroyasu Konno, Tracey Lin, Renyi Wu, Xinchuan Dai, Shou Li, Grace Wang, Min Chen, Wenying Li, Lina Wang, Bee-Chun Sun, Zhen Luo, Tom Huang, Yuping Chen, John Zhang, Qiuping Ye, David Bellovin, Bing Wan, Lishan Kang, Christopher Szeto, Karl Hsu, Omar Kabbarah
Publikováno v: Cancer Research Communications. 2:937-950
CLDN18.2 (Claudin18.2)-targeting therapeutic antibodies have shown promising clinical efficacy in approximately 30% of gastric cancers expressing high levels of CLDN18.2 and less pronounced activity in low expressing malignancies. Here, we report tha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::40e38579a83e8994cc7832763313ddf6
https://doi.org/10.1158/2767-9764.crc-22-0216
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8
Discovery of a Potent Steroidal Glucocorticoid Receptor Antagonist with Enhanced Selectivity against the Progesterone and Androgen Receptors (OP-3633)
Autor: Xi Chen, John Eksterowicz, Jessica Sun, Tatiana Zavorotinskaya, Valeria R. Fantin, Xuelei Yan, Wayne Kong, Dena Sutimantanapi, Yosup Rew, Xiaohui Du, Haiying Zhou, Liusheng Zhu, Daqing Sun, Tom Huang, Qiuping Ye, Julio C. Medina, Nadine Jahchan
Publikováno v: Journal of Medicinal Chemistry. 62:6751-6764
Structure-based modification of mifepristone (1) led to the discovery of novel mifepristone derivatives with improved selectivity profile. Addition of a methyl group at the C10 position of the steroid has a significant impact on progesterone receptor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8f205ab8f3951dd5ee98d5cf9ed9d46
https://doi.org/10.1021/acs.jmedchem.9b00711
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9
Abstract 2594: Discovery and characterization of ZL-2201, a potent, highly-selective, and orally bioavailable small-molecule DNA-PK inhibitor
Autor: Shruti Lal, Bee-Chun Sun, Yuping Chen, Tom Huang, Neil Bhola, Vivian Morton, Kevin Chen, Shanghua Xia, Haoyu Zhang, Qiuping Ye, Petter Veiby, David I. Bellovin, Yuhua Ji
Publikováno v: Cancer Research. 82:2594-2594
DNA-damaging poisons and replicative stress commonly result in increased double-strand breaks (DSBs) in tumor cells. Non-homologous end joining (NHEJ), driven by the enzymatic function of DNA-PK, is one of the critical pathways employed to repair suc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::27561bf2cf06cd4a45062876bbbd2398
https://doi.org/10.1158/1538-7445.am2022-2594
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