Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Tom Hsieh"'
Autor:
Shaoyi Sun, Ray Chui, Ivana Rajlic, Jonathan Langille, Qi Jia, Shifeng Liu, Jianyu Sun, Wendy Young, Sultan Chowdhury, Jianmin Fu, Jing Zhong, Mikhail Chafeev, Zaihui Zhang, Sazzad Hossain, Henry Verschoof, Mark Wood, Kuldip Khakh, Tom Hsieh, Serguei Sviridov, Audrey Wang, Xing Cheng, Rainbow Kwan, Cadieux Jean-Jacques
Publikováno v:
Medicinal Chemistry Research. 22:1825-1836
The structure–activity relationship of a new series of tetracyclic spirooxindoles led to the discovery of compound 25a, a potent hNaV1.7 blocker with improved ADME properties and in vivo efficacy in the CFA-induced inflammatory pain model.
Publikováno v:
Chem. Sci.. 2:544-551
We report a novel strategy for the formal activation of sp3 C–O bonds under Ru catalysis. In this reaction, an O-alkylpyridine undergoes migratory rearrangement to its corresponding N-alkylpyridone via coordination of the Lewis basic N atom. This t
Autor:
Tomohiro Wada, Hauke Nehrenheim, Mengu Cho, Kazuhiro Toyoda, Taishi Endo, Tom Hsieh, Frankie Wong, Bao Hoang
Publikováno v:
3rd AIAA Atmospheric Space Environments Conference.
Publikováno v:
ChemInform. 42
A novel and distinct strategy for sp3 etheral C—O bond activation towards the preparation of N-alkylated 2-pyridones and related heterocycles is developed.
Autor:
Vy M. Dong, Tom Hsieh
Publikováno v:
ChemInform. 40
Nitroalkenes have been called ‘chemical chameleons’ due to their versatility in numerous synthetic transformations. Herein, we describe the first transition metal-catalyzed transformation of conjugated nitroalkenes into indoles. Under mild reacti
Autor:
Vy M. Dong, Tom Hsieh
Publikováno v:
Synthesis. 2011:3926-3926