Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Tom H Ottenhoff"'
Autor:
Ekta Lachmandas, Frank Vrieling, Louis G Wilson, Simone A Joosten, Mihai G Netea, Tom H Ottenhoff, Reinout van Crevel
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0117941 (2015)
Type 2 diabetes mellitus is an established risk factor for tuberculosis but the underlying mechanisms are largely unknown. We examined the effects of hyperglycaemia, a hallmark of diabetes, on the cytokine response to and macrophage infection with My
Externí odkaz:
https://doaj.org/article/654bd959c93543248bf417ae1315fc7c
Autor:
Paulin N Essone, Novel N Chegou, Andre G Loxton, Kim Stanley, Magdalena Kriel, Gian van der Spuy, Kees L Franken, Tom H Ottenhoff, Gerhard Walzl
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102584 (2014)
BACKGROUND: We previously identified Mycobacterium tuberculosis (M.tb) antigen-induced host markers that showed promise as TB diagnostic candidates in 7-day whole blood culture supernatants. The aim of the present study was to evaluate the utility of
Externí odkaz:
https://doaj.org/article/458f59a62f4c443da9d238626a1ee5e3
Autor:
Myrsini Kaforou, Victoria J Wright, Tolu Oni, Neil French, Suzanne T Anderson, Nonzwakazi Bangani, Claire M Banwell, Andrew J Brent, Amelia C Crampin, Hazel M Dockrell, Brian Eley, Robert S Heyderman, Martin L Hibberd, Florian Kern, Paul R Langford, Ling Ling, Marc Mendelson, Tom H Ottenhoff, Femia Zgambo, Robert J Wilkinson, Lachlan J Coin, Michael Levin
Publikováno v:
PLoS Medicine, Vol 10, Iss 10, p e1001538 (2013)
BackgroundA major impediment to tuberculosis control in Africa is the difficulty in diagnosing active tuberculosis (TB), particularly in the context of HIV infection. We hypothesized that a unique host blood RNA transcriptional signature would distin
Externí odkaz:
https://doaj.org/article/c9a7e833bb4b4edbb6bcb66204d78681
Autor:
Yun-Gyoung Hur, Patricia Gorak-Stolinska, Anne Ben-Smith, Maeve K Lalor, Steven Chaguluka, Russell Dacombe, T Mark Doherty, Tom H Ottenhoff, Hazel M Dockrell, Amelia C Crampin
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79742 (2013)
An IFN-γ response to M. tuberculosis-specific antigens is an effective biomarker for M. tuberculosis infection but it cannot discriminate between latent TB infection and active TB disease. Combining a number of cytokine/chemokine responses to M. tub
Externí odkaz:
https://doaj.org/article/e53d802a4ee04177ae61b6f92bdd9779