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pro vyhledávání: '"Tom Gearan"'
Autor:
Sumio Sugano, Michael A. Schwarzschild, Zhiping Weng, Yutaka Suzuki, Jiang-Fan Chen, Tom Gearan, Martin C. Frith, Liqun Yu, Robert A. Peterfreund, J. Stephen Fink
Publikováno v:
Brain Research. 1000:156-173
The adenosine A(2A) receptor (A(2A)R) is abundantly expressed in brain and emerging as an important therapeutic target for Parkinson's disease and potentially other neuropsychiatric disorders. To understand the molecular mechanisms of A(2A)R gene exp
Publikováno v:
Journal of Neuroscience Research. 52:93-104
The vasoactive intestinal peptide cytokine response element (VIP CyRE) is responsible for mediating the transcriptional induction of the VIP gene to the neuropoietic cytokines leukemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF). I
Autor:
Tom Gearan, Steven A. Reeves, Tiziana Servidei, George D. Yancopoulos, Neil Stahl, J. Stephen Fink, Thomas Farruggella, Aviva J. Symes
Publikováno v:
Current Biology. 7(9):697-700
Ciliary neurotrophic factor, along with other neuropoietic cytokines, signals through the shared receptor subunit gp130 [1–3], leading to the tyrosine phosphorylation of a number of substrates [4,5], including the transcription factors STAT1 and ST
Publikováno v:
Parkinsonismrelated disorders. 8(1)
The stress-activated protein kinase (SAPK) cascade serves a critical role in the apoptotic death of neuronal cells in response to a variety of cellular stresses. Recent in vitro and in vivo evidence has directly implicated this kinase in the death of