Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Tom G. Keulers"'
Autor:
Tom G. Keulers, Sten F. Libregts, Joel E.J. Beaumont, Kim G. Savelkouls, Johan Bussink, Hans Duimel, Ludwig Dubois, Marijke I. Zonneveld, Carmen López‐Iglesias, Karel Bezstarosti, Jeroen A. Demmers, Marc Vooijs, Marca Wauben, Kasper M.A. Rouschop
Publikováno v:
Journal of Extracellular Vesicles, Vol 10, Iss 14, Pp n/a-n/a (2021)
Abstract Tumour hypoxia is a hallmark of solid tumours and contributes to tumour progression, metastasis development and therapy resistance. In response to hypoxia, tumour cells secrete pro‐angiogenic factors to induce blood vessel formation and re
Externí odkaz:
https://doaj.org/article/af6b9ede953b475aa1ad89c65bcf4ab4
Autor:
Tom G. Keulers, Alexander Koch, Marike W. van Gisbergen, Lydie M.O. Barbeau, Marijke I. Zonneveld, Monique C. de Jong, Kim G.M. Savelkouls, Roel G. Wanders, Johan Bussink, Veerle Melotte, Kasper M.A. Rouschop
Publikováno v:
Autophagy, 18(8), 1898-1914. Landes Bioscience
Autophagy, 18, 1898-1914
Autophagy, 18, 8, pp. 1898-1914
Autophagy, 18, 1898-1914
Autophagy, 18, 8, pp. 1898-1914
Contains fulltext : 283427.pdf (Publisher’s version ) (Open Access) Hypoxia is a common feature of solid tumors and is associated with increased tumor progression, resistance to therapy and increased metastasis. Hence, tumor hypoxia is a prognostic
Autor:
Simone L. Schonkeren, Glenn Rademakers, Remond J.A. Fijneman, Pieter Vanden Berghe, Meike de Wit, David W. Threadgill, Kasper M.A. Rouschop, Amy Marie Holland, Tim G. A. M. Wolfs, Alexander Koch, Laura Moonen, Edith van den Boezem, Jaleesa R M Van der Meer, Marion J.J. Gijbels, Werend Boesmans, Tom G. Keulers, Robert M.W. Hofstra, Veerle Melotte, Nathalie Vaes, Connie R. Jimenez, Kim M. Smits, Jeroen Demmers
Publikováno v:
EMBO Reports, 22(6):e51913. Wiley-Blackwell
Embo Reports, 22(6):e51913. Wiley
EMBO reports, 22(6):e51913. Wiley-Blackwell
Vaes, N, Schonkeren, S L, Rademakers, G, Holland, A M, Koch, A, Gijbels, M J, Keulers, T G, de Wit, M, Moonen, L, van der Meer, J R M, van den Boezem, E, Wolfs, T G A M, Threadgill, D W, Demmers, J, Fijneman, R J A, Jimenez, C R, Vanden Berghe, P, Smits, K M, Rouschop, K M A, Boesmans, W, Hofstra, R M W & Melotte, V 2021, ' Loss of enteric neuronal Ndrg4 promotes colorectal cancer via increased release of Nid1 and Fbln2 ', EMBO Reports, vol. 22, no. 6, e51913, pp. e51913 . https://doi.org/10.15252/embr.202051913
EMBO Reports
Embo Reports, 22(6):e51913. Wiley
EMBO reports, 22(6):e51913. Wiley-Blackwell
Vaes, N, Schonkeren, S L, Rademakers, G, Holland, A M, Koch, A, Gijbels, M J, Keulers, T G, de Wit, M, Moonen, L, van der Meer, J R M, van den Boezem, E, Wolfs, T G A M, Threadgill, D W, Demmers, J, Fijneman, R J A, Jimenez, C R, Vanden Berghe, P, Smits, K M, Rouschop, K M A, Boesmans, W, Hofstra, R M W & Melotte, V 2021, ' Loss of enteric neuronal Ndrg4 promotes colorectal cancer via increased release of Nid1 and Fbln2 ', EMBO Reports, vol. 22, no. 6, e51913, pp. e51913 . https://doi.org/10.15252/embr.202051913
EMBO Reports
The N‐Myc Downstream‐Regulated Gene 4 (NDRG4), a prominent biomarker for colorectal cancer (CRC), is specifically expressed by enteric neurons. Considering that nerves are important members of the tumor microenvironment, we here establish differe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7a8c4ad6b520a89d4afdcc7f87119a2
https://lirias.kuleuven.be/handle/123456789/675939
https://lirias.kuleuven.be/handle/123456789/675939
Publikováno v:
Cancers, Vol 12, Iss 2463, p 2463 (2020)
Cancers
Cancers
Simple Summary Although the principle of personalized medicine has been the focus of attention, many cancer therapies are still based on a one-size-fits-all approach. The same holds true for targeting cancer cell survival mechanism that allows cancer
Autor:
Resi M. E. Colaris, Kim G.M. Savelkouls, Johan Bussink, Marijke I. Zonneveld, Kasper M.A. Rouschop, Barry Jutten, Onno P.M. Teernstra, Julio Sotelo, Hanneke J.M. Peeters, Ruud Clarijs, Marc Vooijs, Linda Ackermans, Guido Lammering, Inge Compter, Olaf E. M. G. Schijns, Marco B.E. Schaaf, Ludwig Dubois, Jan Theys, Tom G. Keulers
Publikováno v:
Autophagy
Autophagy, 14, 2, pp. 283-295
Autophagy, 14, 283-295
Autophagy, 14(2), 283-295. Landes Bioscience
Autophagy, 14, 2, pp. 283-295
Autophagy, 14, 283-295
Autophagy, 14(2), 283-295. Landes Bioscience
Expression of EGFRvIII is frequently observed in glioblastoma and is associated with increased cellular proliferation, enhanced tolerance to metabolic stresses, accelerated tumor growth, therapy resistance and poor prognosis. We observed that express
Publikováno v:
Faseb Journal, 30(12), 3961-3978. FASEB
From yeast to mammals, autophagy is an important mechanism for sustaining cellular homeostasis through facilitating the degradation and recycling of aged and cytotoxic components. During autophagy, cargo is captured in double-membraned vesicles, the
Autor:
Twan van den Beucken, Barry Jutten, Tom G. Keulers, Kasper M.A. Rouschop, Kim G.M. Savelkouls, Roger W. L. Godschalk, Marc Vooijs, Frederik-Jan van Schooten, Hanneke J.M. Peeters, Marco B.E. Schaaf
Publikováno v:
Radiotherapy and Oncology, 114(3), 406-412. Elsevier Ireland Ltd
Background (Pre)clinical studies indicate that autophagy inhibition increases response to anti-cancer therapies. Although promising, due to contradicting reports, it remains unclear if radiation therapy changes autophagy activity and if autophagy inh
Autor:
Niek van Bree, Ilze Bot, Bart J.M. van Vlijmen, Tom G. Keulers, Marijke M. Westra, Thomas G. Cotter, Theo J.C. Van Berkel, Erik A.L. Biessen, Lieve Temmerman, Kim L. L. Habets, Johan van der Vlag, Martine Bot
Publikováno v:
Scientific Reports, 7
Scientific Reports
Scientific Reports, 7, 3086
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific reports 7, 3086 (2017). doi:10.1038/s41598-017-02771-4
Scientific Reports, 7:3086. Nature Publishing Group
Scientific Reports
Scientific Reports, 7, 3086
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific reports 7, 3086 (2017). doi:10.1038/s41598-017-02771-4
Scientific Reports, 7:3086. Nature Publishing Group
Proapoptotic Bcl-2 family member Bim is particularly relevant for deletion of autoreactive and activated T and B cells, implicating Bim in autoimmunity. As atherosclerosis is a chronic inflammatory process with features of autoimmune disease, we inve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d1d7584ff49b80db216d02137d3e757
https://hdl.handle.net/2066/174145
https://hdl.handle.net/2066/174145
Publikováno v:
Frontiers in Oncology
Frontiers in Oncology, Vol 6 (2016)
Frontiers in Oncology, 6:251. Frontiers Media S.A.
Frontiers in Oncology, Vol 6 (2016)
Frontiers in Oncology, 6:251. Frontiers Media S.A.
Autophagy is best known as a lysosomal degradation and recycling pathway to maintain cellular homeostasis. During autophagy, cytoplasmic content is recognized and packed in autophagic vacuoles, or autophagosomes, and targeted for degradation. However
Publikováno v:
Cancers
Cancers, Vol 11, Iss 2, p 154 (2019)
Cancers, Vol 11, Iss 2, p 154 (2019)
Tumour hypoxia is a common feature of solid tumours that contributes to poor prognosis after treatment. This is mainly due to increased resistance of hypoxic cells to radio- and chemotherapy and the association of hypoxic cells with increased metasta