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pro vyhledávání: '"Tom G. Consler"'
Autor:
Aaron B. Miller, Steve Blanchard, Kate A. Dwornik, Dallas K. Croom, Robert T. Gampe, Tom G. Consler, James M. Lenhard, Olivia Ittoop, Valerie G. Montana, Randy K. Bledsoe, and Andrea Ayscue, Darryl Lynn Mcdougald, Curt D. Haffner, H. Eric Xu
Publikováno v:
Journal of Medicinal Chemistry. 47:2010-2029
A series of tetrahydrobenzofuranyl and tetrahydrobenzothienyl propenoic acids that showed potent agonist activity against RXRalpha were synthesized via a structure-based design approach. Among the compounds studied, 46a,b showed not only very good po
Autor:
Manuel C. Peitsch, Tom G. Consler, Murray McKinnon, Timothy N.C. Wells, Michael D. Edgerton, Richard Fish, Derril H. Willard, Frederic Borlat, Christian Y. Arod, Amanda Elizabeth Inn Proudfoot, Pierre Graber, Iain Uings
Publikováno v:
The Journal of biological chemistry. 272(33)
Interleukin-5 (IL-5), a disulfide-linked homodimer, can be induced to fold as a biological active monomer by extending the loop between its third and fourth helices (Dickason, R. R., and Huston, D. P. (1996) Nature 379, 652–655). We have designed e