Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Tom F. A. de Greef"'
Autor:
Anna-Maria Makri Pistikou, Glenn A. O. Cremers, Bryan L. Nathalia, Theodorus J. Meuleman, Bas W. A. Bögels, Bruno V. Eijkens, Anne de Dreu, Maarten T. H. Bezembinder, Oscar M. J. A. Stassen, Carlijn C. V. Bouten, Maarten Merkx, Roman Jerala, Tom F. A. de Greef
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The rational design and implementation of synthetic mammalian communication systems can unravel fundamental design principles of cell communication circuits and offer a framework for engineering of designer cell consortia with potential appl
Externí odkaz:
https://doaj.org/article/220f498c433c4182ac83250ea66150af
A microfluidic optimal experimental design platform for forward design of cell-free genetic networks
Autor:
Bob van Sluijs, Roel J. M. Maas, Ardjan J. van der Linden, Tom F. A. de Greef, Wilhelm T. S. Huck
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Characterization of cell-free genetic networks is inherently difficult. Here the authors use optimal experimental design and microfluidics to improve characterization, demonstrating modularity and predictability of parts in applied test cases.
Externí odkaz:
https://doaj.org/article/206eb30720014e72b1bb5398ec77eddd
Autor:
Yan Ni, Bas J. H. M. Rosier, Eva A. van Aalen, Eva T. L. Hanckmann, Lieuwe Biewenga, Anna-Maria Makri Pistikou, Bart Timmermans, Chris Vu, Sophie Roos, Remco Arts, Wentao Li, Tom F. A. de Greef, Marcel M. G. J. van Borren, Frank J. M. van Kuppeveld, Berend-Jan Bosch, Maarten Merkx
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Many current immunoassays require multiple washing, incubation and optimization steps. Here the authors present Ratiometric Plug-and-Play Immunodiagnostics (RAPPID), a generic assay platform that uses ratiometric bioluminescent detection to allow san
Externí odkaz:
https://doaj.org/article/9c6f00283d7b49f6a84e253e1ef16ce1
Publikováno v:
Bioengineering, Vol 10, Iss 4, p 466 (2023)
Chemical reaction networks can be utilised as basic components for nucleic acid feedback control systems’ design for Synthetic Biology application. DNA hybridisation and programmed strand-displacement reactions are effective primitives for implemen
Externí odkaz:
https://doaj.org/article/7df6b497327242258ad7ae2f9f92ca3c
Autor:
Lenny H. H. Meijer, Alex Joesaar, Erik Steur, Wouter Engelen, Rutger A. van Santen, Maarten Merkx, Tom F. A. de Greef
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Naturally evolved regulatory circuits have hierarchical layers of signal generation and processing. Here, the authors emulate these networks using feedback-controlled DNA circuits that convert upstream signaling to downstream enzyme activity in a swi
Externí odkaz:
https://doaj.org/article/a0c209b4d05a45be9da69efaa3c73650
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Existing DNA based circuits, designed to perform logic operations and signal processing, are generally responsive to DNA or RNA inputs. Here, the authors show that antibodies can actuate DNA logic gates, opening the way to applications of DNA computi
Externí odkaz:
https://doaj.org/article/64f594ec6a344af8979cb00882632e2f
Publikováno v:
ACS Central Science, Vol 2, Iss 4, Pp 232-241 (2016)
Externí odkaz:
https://doaj.org/article/6f4ff61f94884cd8a61ff0782669d570
Autor:
Jeroen Deckers, Tom Anbergen, Ayla M. Hokke, Anne de Dreu, David P. Schrijver, Koen de Bruin, Yohana C. Toner, Thijs J. Beldman, Jamie B. Spangler, Tom F. A. de Greef, Francesca Grisoni, Roy van der Meel, Leo A. B. Joosten, Maarten Merkx, Mihai G. Netea, Willem J. M. Mulder
Publikováno v:
Nature Reviews Bioengineering, 1(4), 286-303. Nature Publishing Group
Cytokines have pivotal roles in immunity, making them attractive as therapeutics for a variety of immune-related disorders. However, the widespread clinical use of cytokines has been limited by their short blood half-lives and severe side effects cau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::549b7f34e4d03ce8b707bab6067bde72
https://doi.org/10.1038/s44222-023-00030-y
https://doi.org/10.1038/s44222-023-00030-y
Autor:
Anna-Maria Makri Pistikou, Glenn A.O. Cremers, Bryan L. Nathalia, Bas W.A. Bögels, Theodorus J. Meuleman, Bruno V. Eijkens, Anne de Dreu, Maarten T.H. Bezembinder, Oscar M.J.A. Stassen, Carlijn C.V. Bouten, Maarten Merkx, Roman Jerala, Tom F. A. de Greef
In support of the (pre-print) publication "Engineering a Scalable and Orthogonal Platform for Synthetic Communication in Mammalian Cells" we share the following datasets: SEAP activity and calibration curve values ELISA values Flow cytometry FCS file
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::607e235f6f2c3eac12cf64886330d96e
Autor:
Bas W. A. Bögels, Bichlien H. Nguyen, David Ward, Levena Gascoigne, David P. Schrijver, Anna-Maria Makri Pistikou, Alex Joesaar, Shuo Yang, Ilja K. Voets, Willem J. M. Mulder, Andrew Phillips, Stephen Mann, Georg Seelig, Karin Strauss, Yuan-Jyue Chen, Tom F. A. de Greef
Publikováno v:
Nature Nanotechnology, pp. 1-14
Nature Nanotechnology, 2023, 1-14
Nature Nanotechnology, 2023, 1-14
DNA has emerged as an attractive medium for archival data storage due to its durability and high information density. Scalable parallel random access to information is a desirable property of any storage system. For DNA-based storage systems, however
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbb8c27614ee022bfcd6efeb0dc3f7dd
https://repository.ubn.ru.nl/handle/2066/293003
https://repository.ubn.ru.nl/handle/2066/293003