Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Tom Ellenberger"'
Autor:
Jerry H. Houl, Zu Ye, Chris A. Brosey, Lakshitha P. F. Balapiti-Modarage, Sarita Namjoshi, Albino Bacolla, Daniel Laverty, Brian L. Walker, Yasin Pourfarjam, Leslie S. Warden, Naga Babu Chinnam, Davide Moiani, Roderick A. Stegeman, Mei-Kuang Chen, Mien-Chie Hung, Zachary D. Nagel, Tom Ellenberger, In-Kwon Kim, Darin E. Jones, Zamal Ahmed, John A. Tainer
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
PARG catalyzes the removal of poly(ADP-ribose) (PAR) from target proteins and executes critical functions in the DNA damage response. Here the authors provide structural and biological insight with small molecule PARG inhibitors and show that PARG in
Externí odkaz:
https://doaj.org/article/b8239efdcde244de83ae43188c91b2d3
Autor:
Fiorella Ghisays, Cynthia S. Brace, Shawn M. Yackly, Hyock Joo Kwon, Kathryn F. Mills, Elena Kashentseva, Igor P. Dmitriev, David T. Curiel, Shin-ichiro Imai, Tom Ellenberger
Publikováno v:
Cell Reports, Vol 10, Iss 10, Pp 1665-1673 (2015)
The NAD+-dependent protein deacetylase SIRT1 regulates energy metabolism, responses to stress, and aging by deacetylating many different proteins, including histones and transcription factors. The mechanisms controlling SIRT1 enzymatic activity are c
Externí odkaz:
https://doaj.org/article/3c0233978c70441d9ae8a5b0bac7801b
Autor:
Alan E. Tomkinson, Alexander D. MacKerell, Gerald M. Wilson, Tom Ellenberger, Barbara Dziegielewska, Xiao Zhu, Shijun Zhong, Xi Chen
Supplementary Figure 1 from Rational Design of Human DNA Ligase Inhibitors that Target Cellular DNA Replication and Repair
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f68e6cf4fe92cef58d9dd043c294a5
https://doi.org/10.1158/0008-5472.22374645
https://doi.org/10.1158/0008-5472.22374645
Autor:
Alan E. Tomkinson, Alexander D. MacKerell, Gerald M. Wilson, Tom Ellenberger, Barbara Dziegielewska, Xiao Zhu, Shijun Zhong, Xi Chen
Based on the crystal structure of human DNA ligase I complexed with nicked DNA, computer-aided drug design was used to identify compounds in a database of 1.5 million commercially available low molecular weight chemicals that were predicted to bind t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75cb159977d4f9c0d12d9bd73e0d4a89
https://doi.org/10.1158/0008-5472.c.6497526
https://doi.org/10.1158/0008-5472.c.6497526
Autor:
Alan E. Tomkinson, Alexander D. MacKerell, Gerald M. Wilson, Tom Ellenberger, Barbara Dziegielewska, Xiao Zhu, Shijun Zhong, Xi Chen
Supplementary Figure 5 from Rational Design of Human DNA Ligase Inhibitors that Target Cellular DNA Replication and Repair
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e117d883c370f88844bd98ba02405df3
https://doi.org/10.1158/0008-5472.22374633.v1
https://doi.org/10.1158/0008-5472.22374633.v1
Autor:
Alan E. Tomkinson, Alexander D. MacKerell, Gerald M. Wilson, Tom Ellenberger, Barbara Dziegielewska, Xiao Zhu, Shijun Zhong, Xi Chen
Supplementary Figure 2 from Rational Design of Human DNA Ligase Inhibitors that Target Cellular DNA Replication and Repair
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45edc5839bf2c7640d729a7dacecfa03
https://doi.org/10.1158/0008-5472.22374642.v1
https://doi.org/10.1158/0008-5472.22374642.v1
Autor:
Alan E. Tomkinson, Alexander D. MacKerell, Gerald M. Wilson, Tom Ellenberger, Barbara Dziegielewska, Xiao Zhu, Shijun Zhong, Xi Chen
Supplementary Figure 4 from Rational Design of Human DNA Ligase Inhibitors that Target Cellular DNA Replication and Repair
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b53c2d45cde909389d1bfb349626a3ba
https://doi.org/10.1158/0008-5472.22374636.v1
https://doi.org/10.1158/0008-5472.22374636.v1
Autor:
Alan E. Tomkinson, Alexander D. MacKerell, Gerald M. Wilson, Tom Ellenberger, Barbara Dziegielewska, Xiao Zhu, Shijun Zhong, Xi Chen
Supplementary Figure 3 from Rational Design of Human DNA Ligase Inhibitors that Target Cellular DNA Replication and Repair
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::148ee8c3d241cd0ef2ebeb6904f1d7ea
https://doi.org/10.1158/0008-5472.22374639
https://doi.org/10.1158/0008-5472.22374639
Autor:
Tom Ellenberger, Claudia Guadalupe Benítez Cardoza, Luis G. Brieba, Antolín Peralta-Castro, Víctor Juarez-Quintero
Publikováno v:
Biochemical Journal. 478:2665-2679
The crystal structure of full-length T7 DNA polymerase in complex with its processivity factor thioredoxin and double-stranded DNA in the polymerization active site exhibits two novel structural motifs in family-A DNA polymerases: an extended β-hair
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::482a463256bc6f427552f823556cbeea
https://doi.org/10.1042/bcj20200922
https://doi.org/10.1042/bcj20200922
Autor:
Henry Salvo, Kasie L. Stephens, Brittania J. Bintz, Daniel J. Rosenberg, Brittni M. Foster, Maria D. Gainey, Michal Hammel, Tom Ellenberger, Jamie R. Wallen
Publikováno v:
Biochemistry
Recent structural studies of the bacteriophage T7 DNA replication system have shed light on how multiple proteins assemble to copy two antiparallel DNA strands. In T7, acidic C-terminal tails of both the primase-helicase and single-stranded DNA bindi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c04b364640ecb4ea6faaac63770a09
https://doi.org/10.1021/acs.biochem.9b00525
https://doi.org/10.1021/acs.biochem.9b00525