Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Tom Dixon"'
Autor:
Tom Dixon, Derek MacPherson, Barmak Mostofian, Taras Dauzhenka, Samuel Lotz, Dwight McGee, Sharon Shechter, Utsab R. Shrestha, Rafal Wiewiora, Zachary A. McDargh, Fen Pei, Rajat Pal, João V. Ribeiro, Tanner Wilkerson, Vipin Sachdeva, Ning Gao, Shourya Jain, Samuel Sparks, Yunxing Li, Alexander Vinitsky, Xin Zhang, Asghar M. Razavi, István Kolossváry, Jason Imbriglio, Artem Evdokimov, Louise Bergeron, Wenchang Zhou, Jagat Adhikari, Benjamin Ruprecht, Alex Dickson, Huafeng Xu, Woody Sherman, Jesus A. Izaguirre
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-24 (2022)
The formation of ternary degrader-protein complexes is a key step in the targeted degradation of proteins of interest. Here, the authors explore the structure and dynamics of such complexes applying high-performance computer simulations augmented wit
Externí odkaz:
https://doaj.org/article/c2e5bdee6705479cb8aa835a2985b507
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
The free energy of a process is the fundamental quantity that determines its spontaneity or propensity at a given temperature. In particular, the binding free energy of a drug candidate to its biomolecular target is used as an objective quantity in d
Externí odkaz:
https://doaj.org/article/a0097719619747808b7b6341dab3fe9b
Autor:
David W, McCormick, Liesl M, Hagan, Phillip P, Salvatore, Reed, Magleby, Christine, Lee, Sadia, Sleweon, Lavinia, Nicolae, Tom, Dixon, Robert, Banta, Isaac, Ogle, Cristen, Young, Charles, Dusseau, Charles, Ogden, Hannah, Browne, John, Michael Metz, Min-Hsin, Chen, Maria I, Solano, Shannon, Rogers, Alex, Burgin, Mili, Sheth, Bettina, Bankamp, Azaibi, Tamin, Jennifer L, Harcourt, Jacqueline E, Tate, Hannah L, Kirking
Publikováno v:
Vaccine. 41:1769-1773
The preclinical time course of SARS-CoV-2 shedding is not well-described. Understanding this time course will help to inform risk of SARS-CoV-2 transmission. During an outbreak in a congregate setting, we collected paired mid-turbinate nasal swabs fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d57566ecce9f8a7d8501c95526c822f4
https://doi.org/10.1016/j.vaccine.2022.11.030
https://doi.org/10.1016/j.vaccine.2022.11.030
Publikováno v:
American Journal of Potato Research. 99:229-242
Biofumigation has been proposed as an alternative to soil fumigation to manage soil-borne diseases including potato early dying disease complex (PED). This study examined the potential of using brown mustard (Mustard juncea) biofumigation to manage P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c59f04c146bf1265dbeb6422ede01d8
https://doi.org/10.1007/s12230-022-09875-2
https://doi.org/10.1007/s12230-022-09875-2
Autor:
Tom Dixon, Louis-Pierre Comeau, Bernie J. Zebarth, Anne M. Smith, Sherry Fillmore, Gilles Moreau, Sheldon Hann
Publikováno v:
Soil Science Society of America Journal. 86:134-145
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5aab3331677bbe49fbd10481d2b2286
https://doi.org/10.1002/saj2.20342
https://doi.org/10.1002/saj2.20342
Autor:
Tom Dixon, Derek MacPherson, Barmak Mostofian, Taras Dauzhenka, Samuel Lotz, Dwight McGee, Sharon Shechter, Utsab Shrestha, Rafal Wiewiora, Zachary McDargh, Fen Pei, Rajat Pal, Joao Vieira Ribeiro, Tanner Wilkerson, Vipin Sachdeva, Ning Gao, Shourya Jain, Samuel Sparks, Yunxing Li, Alexander Vinitsky, Xin Zhang, Asghar Razavi, István Kolossváry, Jason Imbriglio, Artem Evdokimov, Louise Bergeron, Alex Dickson, Huafeng Xu, Woody Sherman, Jesus Izaguirre
Targeted protein degradation (TPD) has emerged as a powerful approach for removing (rather than inhibiting) proteins implicated in diseases. A key step in TPD is the formation of an induced proximity complex where a degrader molecule recruits an E3 l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5e7b51e04cb88578da974b61782146b
https://doi.org/10.21203/rs.3.rs-1318882/v1
https://doi.org/10.21203/rs.3.rs-1318882/v1
Publikováno v:
Methods in Molecular Biology ISBN: 9781071617663
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28d38dd9533931e58cfaca5918017b4b
https://doi.org/10.1007/978-1-0716-1767-0_15
https://doi.org/10.1007/978-1-0716-1767-0_15
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2385
Simulations of ligand-protein interactions can be very useful for drug design and to gain biological insight. Full pathways of ligand-protein binding can be used to get information about ligand binding transition states, which form the rate-limiting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a4b92c087109f289ae9c52caf0fe877e
https://pubmed.ncbi.nlm.nih.gov/34888727
https://pubmed.ncbi.nlm.nih.gov/34888727
Autor:
Krzysztof Machocki, Zahrah Marhoon, Shaarawi Amjad, Ossama Sehsah, Tom Dixon, Jamal Ud-Din Mohammad
Publikováno v:
Journal of Geotechnology and Energy. 38
Managed pressure drilling (MPD) is a technology that allows for precise wellbore pressure control, especially in formations of uncertain geomechanics. The rotating control device (RCD) is a crucial part of the MPD equipment but is prone to failure. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78bc1a25fe579070553099b6b1a27a51
https://doi.org/10.7494/jge.2021.38.3.4504
https://doi.org/10.7494/jge.2021.38.3.4504