Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Tom Deroo"'
Autor:
Jitesh Neupane, Sabitri Ghimire, Mado Vandewoestyne, Yuechao Lu, Jan Gerris, Rudy Van Coster, Tom Deroo, Dieter Deforce, Stijn Vansteelandt, Petra De Sutter, Björn Heindryckx
Publikováno v:
Cell Reports, Vol 13, Iss 7, Pp 1304-1309 (2015)
Variation in the level of mtDNA heteroplasmy in adult tissues is commonly seen in patients with a mixture of wild-type and mutant mtDNA. A mixture of different mtDNA variants may influence such variation and cause mtDNA segregation bias. We analyzed
Externí odkaz:
https://doaj.org/article/ac06f2f196f14f95a7a9f4b07d3df71a
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23899 (2011)
The Wnt/β-catenin signalling pathway shares a key component, β-catenin, with the cadherin-based adhesion system. The signalling function of β-catenin is conferred by a soluble cytoplasmic pool that is unstable in the absence of a Wnt signal, whils
Externí odkaz:
https://doaj.org/article/1ef85b967ee64b688eb2266d0d1b8f24
Autor:
Yvan Saeys, Ellen Sanders, Rudi Beyaert, Bernd Schierwater, Jens Staal, Kai Kamm, Paco Hulpiau, Ismail Sahin Gul, Frans van Roy, Evi De Keuckelaere, Ulrich Technau, Yasmine Driege, Katrien Staes, Tom Deroo
Publikováno v:
Genome Biology and Evolution
GENOME BIOLOGY AND EVOLUTION
GENOME BIOLOGY AND EVOLUTION
With the genomes available for many animal clades, including the early-branching metazoans, one can readily study the functional conservation of genes across a diversity of animal lineages. Ectopic expression of an animal protein in, for instance, a
Autor:
Margot Van der Jeught, Thomas O'Leary, Petra De Sutter, Winnok H. De Vos, Tom Deroo, Jitesh Neupane, Sylvie Lierman, Susana M. Chuva de Sousa Lopes, Sabitri Ghimire, Björn Heindryckx
Publikováno v:
Stem cells and development
Stem Cells and Development, 24(4), 497-506
Stem Cells and Development, 24(4), 497-506
Early lineage segregation in preimplantation embryos and maintenance of pluripotency in embryonic stem cells (ESCs) are both regulated by specific signaling pathways. Small molecules have been shown to modulate these signaling pathways. We examined t
Autor:
Ji Yeon Hong, Jae Il Park, Annette Li, Peter D. Vize, Kris Vleminckx, Randall T. Moon, Gilbert Weidinger, Rachel K. Miller, Pierre D. McCrea, Tom Deroo, Hong Ji, Jon P. Lyons, Tinneke Denayer, Elizabeth A. Jones, Xiaolan Zhou
Publikováno v:
Mechanisms of Development. 126:142-159
The pronephric kidney controls water and electrolyte balance during early fish and amphibian embryogenesis. Many Wnt signaling components have been implicated in kidney development. Specifically, in Xenopus pronephric development as well as the murin
Autor:
Wouter Martens, Walter Fiers, Tom Deroo, Kenny Roose, Mostafa Bentahir, Frederik Vervalle, Xavier Saelens, Joël Vandekerckhove, Marina De Filette
Publikováno v:
Journal of Biological Chemistry. 283:11382-11387
Matrix protein 2 (M2) of influenza A is a tetrameric type III membrane protein that functions as a proton-selective channel. The extracellular domain (M2e) has remained nearly invariable since the first human influenza strain was isolated in 1933. By
Autor:
Susana M. Chuva de Sousa Lopes, Margot Van der Jeught, Matthias S Roost, Björn Heindryckx, Sharat Warrier, Pieter Mestdagh, Galbha Duggal, Luc Peelman, Björn Menten, Dieter Deforce, Petra De Sutter, Sabitri Ghimire, Jo Vandesompele, Bastiaan T. Heijmans, Sylvie Lierman, Tom Deroo, Roderick C. Slieker, Ria Cornelissen, Dorien Broekaert, Ann Van Soom
Publikováno v:
Stem Cells, 33(9), 2686-2698. Wiley-Blackwell
Duggal, G, Warrier, S, Ghimire, S, Broekaert, D, Van Der Jeught, M, Lierman, S, Deroo, T, Peelman, L, Van Soom, A, Cornelissen, R, Menten, B, Mestdagh, P, Vandesompele, J, Roost, M, Slieker, R C, Heijmans, B T, Deforce, D, De Sutter, P, De Sousa Lopes, S C & Heindryckx, B 2015, ' Alternative Routes to Induce Naïve Pluripotency in Human Embryonic Stem Cells ', Stem Cells, vol. 33, no. 9, pp. 2686-2698 . https://doi.org/10.1002/stem.2071
STEM CELLS
STEM CELLS, 33(9), 2686-2698
Duggal, G, Warrier, S, Ghimire, S, Broekaert, D, Van Der Jeught, M, Lierman, S, Deroo, T, Peelman, L, Van Soom, A, Cornelissen, R, Menten, B, Mestdagh, P, Vandesompele, J, Roost, M, Slieker, R C, Heijmans, B T, Deforce, D, De Sutter, P, De Sousa Lopes, S C & Heindryckx, B 2015, ' Alternative Routes to Induce Naïve Pluripotency in Human Embryonic Stem Cells ', Stem Cells, vol. 33, no. 9, pp. 2686-2698 . https://doi.org/10.1002/stem.2071
STEM CELLS
STEM CELLS, 33(9), 2686-2698
Human embryonic stem cells (hESCs) closely resemble mouse epiblast stem cells exhibiting primed pluripotency unlike mouse ESCs (mESCs), which acquire a naïve pluripotent state. Efforts have been made to trigger naïve pluripotency in hESCs for subse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c6db555b3a634e19273b62d1365d75d
https://hdl.handle.net/1887/105546
https://hdl.handle.net/1887/105546
Autor:
Dieter Deforce, Petra De Sutter, Sylvie Lierman, Sabitri Ghimire, Margot Van der Jeught, Jasin Taelman, Björn Heindryckx, Galbha Duggal, Susana M. Chuva de Sousa Lopes, Tom Deroo
Publikováno v:
Cellular Reprogramming, 17(3), 170-180
In mice, inhibition of both the fibroblast growth factor (FGF) mitogen-activated protein kinase kinase/extracellular-signal regulated kinase (MEK/Erk) and the Wnt signaling inhibitor glycogen synthase-3β (GSK3β) enables the derivation of mouse embr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f33fc09c706aaa41fc7c3b20a97e4f6a
http://hdl.handle.net/1887/107346
http://hdl.handle.net/1887/107346
Autor:
Thi Thu Ha Nguyen, Si Wan Kim, Hong Ji, Michelle Craig Barton, Jon P. Lyons, Pierre D. McCrea, Kris Vleminckx, Kyucheol Cho, Tom Deroo, Jae Il Park
Publikováno v:
Developmental Cell. 8:843-854
Summary β-catenin-dependent or canonical Wnt signals are fundamental in animal development and tumor progression. Using Xenopus laevis , we report that the BTB/POZ zinc finger family member Kaiso directly represses canonical Wnt gene targets ( Siamo
Publikováno v:
Journal of Biological Chemistry. 279:50670-50675
Analysis of canonical Wnt signaling during vertebrate development by means of knock-out or transgenic approaches is often hampered by functional redundancy as well as pathway bifurcations downstream of the manipulated components. We report the design