Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Tom Chu"'
Autor:
Fei Tang, Rebecca Kunder, Tom Chu, Avis Hains, Allen Nguyen, Jacqueline M. McBride, Yu Zhong, Sara Santagostino, Maria Wilson, Abigail Trenchak, Liuxi Chen, Justin Ly, Anita Moein, Nicholas Lewin‐Koh, Vibha Raghavan, Uyi Osaghae, Chris Wynne, Ryan Owen, David Place
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 9, Pp 1653-1666 (2023)
Abstract Inappropriate and chronic activation of the cytosolic NOD‐, LRR‐, and pyrin domain‐containing 3 (NLRP3) inflammasome, a key component of innate immunity, likely underlies several inflammatory diseases, including coronary artery disease
Externí odkaz:
https://doaj.org/article/7a96997b4ebb4093a90b5db4a16716a5
Autor:
Holly J. Clarke, William H. Yang, Timothy T. Lu, Joshua Galanter, Petra Staubach, Tonny Tanus, Tracy Burgess, Gordon Sussman, Jeremy J. Lim, Leslie W. Chinn, Remi Gagnon, D. James Haddon, Tom Chu, Marcus Maurer, Anastasia Teterina, Martin Metz
Publikováno v:
Nature Medicine. 27:1961-1969
Bruton’s tyrosine kinase (BTK) is crucial for FceRI-mediated mast cell activation and essential for autoantibody production by B cells in chronic spontaneous urticaria (CSU). Fenebrutinib, an orally administered, potent, highly selective, reversibl
Autor:
Martin, Metz, Gordon, Sussman, Rémi, Gagnon, Petra, Staubach, Tonny, Tanus, William H, Yang, Jeremy J, Lim, Holly J, Clarke, Joshua, Galanter, Leslie W, Chinn, Tom, Chu, Anastasia, Teterina, Tracy, Burgess, D James, Haddon, Timothy T, Lu, Marcus, Maurer
Publikováno v:
Nature Medicine
Bruton’s tyrosine kinase (BTK) is crucial for FcεRI-mediated mast cell activation and essential for autoantibody production by B cells in chronic spontaneous urticaria (CSU). Fenebrutinib, an orally administered, potent, highly selective, reversib
Autor:
Priscilla Horn, Nimer Assy, Jacqueline McBride, Jeremy J. Lim, Rong Deng, Anna Nilsson, Joshua Galanter, Jorge A. Tavel, Allen Nguyen, Mauricio Maia, Melicent C. Peck, Xiaoying Yang, Aide Castro, Elizabeth M. Newton, Michael Silverman, Tom Chu, Chloe Li, Priya Kulkarni
Publikováno v:
Antimicrobial Agents and Chemotherapy
For patients hospitalized with severe influenza A virus infection, morbidity and mortality remain high. MHAA4549A, a human monoclonal antibody targeting the influenza A virus hemagglutinin stalk, has demonstrated pharmacological activity in animal st
Autor:
Adam J. Gehring, Harry L.A. Janssen, Antonio Bertoletti, Amanda Romney-Vanterpool, Aman Mehrotra, June Ann D'Angelo, Tom Chu
Publikováno v:
The Journal of infectious diseases. 222(1)
Background Interferon-α (IFN-α) can suppress production of T-cell polarizing cytokines or induce inhibitory antigen-presenting cells that suppress T-cell activation. Previous studies showed that IFN-α therapy fails to boost virus-specific T-cell i
Autor:
Melicent C. Peck, Mauricio Maia, Jeremy J. Lim, Allen Nguyen, Nimer Assy, Jorge A. Tavel, Tom Chu, Rong Deng, Jacqueline McBride, Michael Silverman, Priscilla Horn, Aide Castro, Anna Nilsson, Elizabeth M. Newton, Chloe Li, Joshua Galanter, Priya Kulkarni, Xiaoying Yang
Publikováno v:
SSRN Electronic Journal.
Background: For patients hospitalized with severe influenza A, morbidity and mortality remain high. MHAA4549A, a human monoclonal antibody targeting the influenza A hemagglutinin stalk, has demonstrated pharmacological activity in animal studies and
Autor:
Carrie C Rosenberger, Jeremy J. Lim, Sharon M Rymut, Nicholas Lewin-Koh, Loren G. Miller, José M. Miró, Wouter L. W. Hazenbos, Melicent C. Peck, Vance G. Fowler, Montserrat Carrasco-Triguero, Jessica Couch, Tom Chu, Aklile Berhanu
Publikováno v:
Open Forum Infectious Diseases
Background New treatment approaches for complicated Staphylococcus aureus bacteremia (SAB) are needed. DSTA4637S is a THIOMABTM antibody-antibiotic conjugate consisting of an engineered human IgG1 monoclonal antibody that binds to wall teichoic acid
Autor:
Tom Chu, Markus Britschgi, Eric Prinssen, Regina Dutkowski, Annette Koerner, Bharat Thakrar, Sudhir Bansod, Craig R Rayner, Stephen Toovey, Alexandra Sirzen-Zelenskaya, Barbara Donner
Publikováno v:
Advances in Therapy. 29:826-848
A 2008 review by our group concluded that the risk of neuropsychiatric adverse events (NPAEs) in influenza patients was not increased by oseltamivir exposure, and did not identify any mechanism by which oseltamivir or its metabolites could cause or w
Publikováno v:
The Journal of Clinical Pharmacology. 47:689-696
The pharmacokinetics of oseltamivir and oseltamivir carboxylate in healthy Japanese (n = 14) and Caucasian (n = 14) males were compared. Subjects in each ethnic group were randomized to twice-daily oral oseltamivir 75 mg, 150 mg, or placebo for 13 do
Autor:
Ignacio Rodriguez, Michael J. Brunda, Tom Chu, Katerina Glavini, Sophie Le Pogam, Edward Gane, Janet Hammond, Sharon Passe, Robert Elston, Jacob George, Donald M. Jensen, Anna Piekarska, Stefan Zeuzem, Isabel Najera
Publikováno v:
Liver international : official journal of the International Association for the Study of the Liver. 36(4)
BACKGROUND & AIMS Setrobuvir is a direct-acting antiviral (DAA) non-nucleoside inhibitor of hepatitis C virus (HCV) polymerase. This study examined interferon-free combinations containing setrobuvir, a ritonavir-boosted protease inhibitor (danoprevir