Zobrazeno 1 - 10
of 195
pro vyhledávání: '"Tom Chou"'
Autor:
Xiangting Li, Tom Chou
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 6, p e1012183 (2024)
Cellular signaling, crucial for biological processes like immune response and homeostasis, relies on specificity and fidelity in signal transduction to accurately respond to stimuli amidst biological noise. Kinetic proofreading (KPR) is a key mechani
Externí odkaz:
https://doaj.org/article/9d4ae4db1ce54088b16c134409658d45
Publikováno v:
Frontiers in Systems Biology, Vol 3 (2023)
Hematopoiesis has been studied via stem cell labeling using barcodes, viral integration sites (VISs), or in situ methods. Subsequent proliferation and differentiation preserve the tag identity, thus defining a clone of mature cells across multiple ce
Externí odkaz:
https://doaj.org/article/a8265ca37027489a9de972e9bae799fe
Publikováno v:
PLOS Global Public Health, Vol 3, Iss 3, p e0000769 (2023)
We examine trends in drug overdose deaths by race, gender, and geography in the United States during the period 2013-2020. Race and gender specific crude rates were extracted from the final National Vital Statistics System multiple cause-of-death mor
Externí odkaz:
https://doaj.org/article/fa89b2e26c754e689fecc6125c2e637e
Publikováno v:
Royal Society Open Science, Vol 9, Iss 6 (2022)
We consider age-structured models with an imposed refractory period between births. These models can be used to formulate alternative population control strategies to China’s one-child policy. By allowing any number of births, but with an imposed d
Externí odkaz:
https://doaj.org/article/7c4f2c3084c74dfb9e93d0341c1f92c6
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 664-690 (2021)
The hypothalamus–pituitary–adrenal (HPA) axis is a key neuroendocrine system implicated in stress response, major depression disorder, and post-traumatic stress disorder. We present a new, compact dynamical systems model for the response of the H
Externí odkaz:
https://doaj.org/article/0d408abcbd304e54ae3d66888131e83b
Publikováno v:
Mathematical Biosciences and Engineering, Vol 17, Iss 1, Pp 28-55 (2020)
For some real-world problems, it is desirable to find multiple global optima as many as possible. The multimodal optimization approach which finds multiple optima in a single run shows significant difference with the single modal optimization approac
Externí odkaz:
https://doaj.org/article/5fb4596c5b174bc7a8d0ecd8973373ea
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
The specificity of T cells is that each T cell has only one T cell receptor (TCR). A T cell clone represents a collection of T cells with the same TCR sequence. Thus, the number of different T cell clones in an organism reflects the number of differe
Externí odkaz:
https://doaj.org/article/1c0e5efdeb4f400b971717fc9cb8f2c1
Publikováno v:
Machine Learning: Science and Technology, Vol 4, Iss 2, p 025024 (2023)
Solving analytically intractable partial differential equations (PDEs) that involve at least one variable defined on an unbounded domain arises in numerous physical applications. Accurately solving unbounded domain PDEs requires efficient numerical m
Externí odkaz:
https://doaj.org/article/18c160c2081a40e7ba4d48fc7d71047e
Autor:
Bhaven A. Mistry, Tom Chou
Publikováno v:
Mathematical Biosciences and Engineering, Vol 16, Iss 5, Pp 4477-4490 (2019)
Flow cytometry is extensively used in cell biology to differentiate cells of interest (mutants) from control cells (wild-types). For mutant cells characterized by expression of a distinct membrane surface structure, fluorescent marker probes can be d
Externí odkaz:
https://doaj.org/article/7eb74cc70d1a4621acb9c8a43714725b
Autor:
Shyr-Shea Chang, Tom Chou
Publikováno v:
Computational Psychiatry, Vol 2, Pp 205-222 (2018)
Bipolar disorder is a common psychiatric dysfunction characterized by recurring episodes of mania and depression. Despite its prevalence, the causes and mechanisms of bipolar disorder remain largely unknown. Recently, theories focusing on the interac
Externí odkaz:
https://doaj.org/article/f197f328dfb44999ad49e1c01d1896d8