Výsledky vyhledávání - "Tom C. Badgett"

Akademický článek

Nanopore sequencing of clonal IGH rearrangements in cell-free DNA as a biomarker for acute lymphoblastic leukemia

Autor: Shilpa Sampathi, Yelena Chernyavskaya, Meghan G. Haney, L. Henry Moore, Isabel A. Snyder, Anna H. Cox, Brittany L. Fuller, Tamara J. Taylor, Donglin Yan, Tom C. Badgett, Jessica S. Blackburn

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

BackgroundAcute Lymphoblastic Leukemia (ALL) is the most common pediatric cancer, and patients with relapsed ALL have a poor prognosis. Detection of ALL blasts remaining at the end of treatment, or minimal residual disease (MRD), and spread of ALL in

Externí odkaz: https://doaj.org/article/88b631c58e034e68bd52d1b457e89b2d

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In situ mass spectrometry imaging reveals heterogeneous glycogen stores in human normal and cancerous tissues

Autor: Lyndsay E A Young, Lindsey R Conroy, Harrison A Clarke, Tara R Hawkinson, Kayli E Bolton, William C Sanders, Josephine E Chang, Madison B Webb, Warren J Alilain, Craig W Vander Kooi, Richard R Drake, Douglas A Andres, Tom C Badgett, Lars M Wagner, Derek B Allison, Ramon C Sun, Matthew S Gentry

Publikováno v: EMBO Molecular Medicine. 14

Glycogen dysregulation is a hallmark of aging, and aberrant glycogen drives metabolic reprogramming and pathogenesis in multiple diseases. However, glycogen heterogeneity in healthy and diseased tissues remains largely unknown. Herein, we describe a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89790a9115af5c70b57f47ea06c209b7
https://doi.org/10.15252/emmm.202216029

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Nanopore sequencing methods detect cell-free DNA associated with MRD and CNS infiltration in pediatric Acute Lymphoblastic Leukemia

Autor: Isabel A. Snyder, Tom C. Badgett, L. Henry Moore, Shilpa Sampathi, Tamara J. Taylor, Anna H. Cox, Meghan G. Haney, Brittany L. Fuller, Yelena Chernyavskaya, Jessica S. Blackburn

Acute Lymphoblastic Leukemia (ALL) patients that are positive for minimal residual disease (MRD) after therapy or have leukemic infiltration into the central nervous system (CNS) are considered high risk and receive intensive chemotherapy regimens. C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a80b19f5abf8a467df29754c44ae18d
https://doi.org/10.1101/2021.09.27.462067

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Cell-Free DNA As a Biomarker for Acute Lymphoblastic Leukemia Relapse in the Central Nervous System

Autor: Meghan G. Haney, Henry Moore, Tom C. Badgett, Jessica S. Blackburn, Shilpa Sampathi, Yelena Chernyavskaya

Publikováno v: Blood. 136:7-8

Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with a relapse rate of 15%. The presence of lymphoblasts in the central nervous system (CNS) is a negative prognostic indicator and a frequent site of disease relapse. CNS diseas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ef400852becff51eb421d9e2a3132d4a
https://doi.org/10.1182/blood-2020-143227

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Chimeric antigen receptor T-cell therapy in patients with neurologic comorbidities

Autor: Stella M. Davies, J. Michael Taylor, Michael Huang, Christine L Phillips, Christa Krupski, Tom C. Badgett, Jeremy D. Rubinstein, Adam S. Nelson, William J. O'Brien

Publikováno v: Pediatric bloodcancerREFERENCES. 67(4)

Chimeric antigen receptor T cells (CAR-T) are an effective and potentially durable treatment for refractory and multiply relapsed B-cell acute lymphoblastic leukemia. Neurotoxicity is frequent after CAR-T cell therapy. Mechanisms driving neurotoxicit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52f3121417a60dcdc074a679126a2cfe
https://pubmed.ncbi.nlm.nih.gov/32020723

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Novel methods to assess cell-free circulating tumor DNA in acute lymphoblastic leukemia

Autor: Meghan G. Haney, Tom C. Badgett, Shilpa Sampathi, Jessica S. Blackburn, Yelena Chernyavskaya, Henry Moore

Publikováno v: Journal of Clinical Oncology. 39:10034-10034

10034 Background: Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with a relatively high relapse rate, which is associated with poor prognosis. Currently, minimal residual disease (MRD) at the end of induction and consolidatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::abfb01c7a4356c6f61849bad3f7b0933
https://doi.org/10.1200/jco.2021.39.15_suppl.10034

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Disclosure of Incidental Findings From Next-Generation Sequencing in Pediatric Genomic Research

Autor: Tom C. Badgett, Javed Khan, Benjamin E. Berkman, Annette Rid, Ruqayyah Abdul-Karim, Sara Chandros Hull, David Wendler

Publikováno v: Pediatrics. 131:564-571

Next-generation sequencing technologies will likely be used with increasing frequency in pediatric research. One consequence will be the increased identification of individual genomic research findings that are incidental to the aims of the research.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d386c7be8805e23d9a70f4f2b5eb965
https://doi.org/10.1542/peds.2012-0084

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MYCN controls an alternative RNA splicing program in high-risk metastatic neuroblastoma

Publikováno v: Cancer letters. 371(2)

The molecular mechanisms underlying the aggressive behavior of MYCN driven neuroblastoma (NBL) is under intense investigation; however, little is known about the impact of this family of transcription factors on the splicing program. Here we used hig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::256b00ef7c3b1d9610860c569d90e435
https://pubmed.ncbi.nlm.nih.gov/26683771

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