Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Tom C Lovelace"'
Autor:
Mark A. Hatcher, Michel Journet, Shiping Xie, John A. Kowalski, Tom C Lovelace, Greg A. Erickson, Christopher J. Pink
Publikováno v:
The Journal of organic chemistry. 87(4)
A novel oxidative activation of a thiolactam was developed for the preparation of methyltriazolo[1,4]benzodiazepine in a single step. A sulfenic acid (R-SOH) was proposed as the activated intermediate with the concurrent formation of acetylhydrazone
Publikováno v:
Organic Process Research & Development. 17:1277-1286
This paper describes the influence of key reaction parameters on the development of a rate model which can be used to forecast starting material conversion independent of scale. A nitro reduction was examined via first principles reaction progress mo
Autor:
Alan Millar, Jennifer F. Toczko, David M. Black, Tom C. Lovelace, Shiping Xie, Brian D. Doan, Roman Davis
Publikováno v:
Tetrahedron: Asymmetry. 19:2015-2019
An efficient highly diastereo- and enantioselective synthesis of the bis-tetrahydrofuran (bis-THF) alcohol of several HIV protease inhibitors, including Brecanavir and Darunavir, has been achieved utilizing an Evans Mukaiyama aldol reaction of (benzy