Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Tom C Kotsimbos"'
Autor:
Wuji Zhang, Louise C Rowntree, Ramona Muttucumaru, Timon Damelang, Malet Aban, Aeron C Hurt, Maria Auladell, Robyn Esterbauer, Bruce Wines, Mark Hogarth, Stephen J Turner, Adam K Wheatley, Stephen J Kent, Sushrut Patil, Sharon Avery, Orla Morrissey, Amy W Chung, Marios Koutsakos, Thi HO Nguyen, Allen C Cheng, Tom C Kotsimbos, Katherine Kedzierska
Publikováno v:
Clinical & Translational Immunology, Vol 12, Iss 6, Pp n/a-n/a (2023)
Abstract Objectives Influenza causes significant morbidity and mortality, especially in high‐risk populations. Although current vaccination regimens are the best method to combat annual influenza disease, vaccine efficacy can be low in high‐risk
Externí odkaz:
https://doaj.org/article/19f39f7a518347a7bba2b6246a782664
Autor:
Sneha Sant, Misty R Jenkins, Pradyot Dash, Katherine A Watson, Zhongfang Wang, Angela Pizzolla, Marios Koutsakos, Thi HO Nguyen, Martha Lappas, Jane Crowe, Tom Loudovaris, Stuart I Mannering, Glen P Westall, Tom C Kotsimbos, Allen C Cheng, Linda Wakim, Peter C Doherty, Paul G Thomas, Liyen Loh, Katherine Kedzierska
Publikováno v:
Clinical & Translational Immunology, Vol 8, Iss 9, Pp n/a-n/a (2019)
Abstract Background Although γδ T cells comprise up to 10% of human peripheral blood T cells, questions remain regarding their role in disease states and T‐cell receptor (TCR) clonal expansions. We dissected anti‐viral functions of human γδ T
Externí odkaz:
https://doaj.org/article/7ff1b72faa64454082fb640c16d1ffe8
Autor:
Lucy C Sullivan, Glen P Westall, Jacqueline M L Widjaja, Nicole A Mifsud, Thi H O Nguyen, Aislin C Meehan, Tom C Kotsimbos, Andrew G Brooks
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135972 (2015)
The human cytomegalovirus (CMV) immune evasion protein, UL40, shares an identical peptide sequence with that found in the leader sequence of many human leukocyte antigen (HLA)-C alleles and when complexed with HLA-E, can modulate NK cell functions vi
Externí odkaz:
https://doaj.org/article/c545f4703e9e458cb6880be00b31d3eb
Autor:
Thi H O Nguyen, Glen P Westall, Tara E Bull, Aislin C Meehan, Nicole A Mifsud, Tom C Kotsimbos
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56042 (2013)
Human Cytomegalovirus (CMV) reactivation continues to influence lung transplant outcomes. Cross-reactivity of anti-viral memory T cells against donor human leukocyte antigens (HLA) may be a contributing factor. We identified cross-reactive HLA-A*02:0
Externí odkaz:
https://doaj.org/article/bbfc30732a794d5eb7ec34b35dd7ed6a
Autor:
Aislin C Meehan, Nicole A Mifsud, Thi H O Nguyen, Bronwyn J Levvey, Greg I Snell, Tom C Kotsimbos, Glen P Westall
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e60144 (2013)
Lung transplantation is a recognised treatment for patients with end stage pulmonary disease. Transplant recipients receive life-long administration of immunosuppressive drugs that target T cell mediated graft rejection. However little is known of th
Externí odkaz:
https://doaj.org/article/4aadebe06b06469092c4303ef69ad2d1
Autor:
Luca, Hensen, Patricia T, Illing, E, Bridie Clemens, Thi H O, Nguyen, Marios, Koutsakos, Carolien E, van de Sandt, Nicole A, Mifsud, Andrea T, Nguyen, Christopher, Szeto, Brendon Y, Chua, Hanim, Halim, Simone, Rizzetto, Fabio, Luciani, Liyen, Loh, Emma J, Grant, Phillipa M, Saunders, Andrew G, Brooks, Steve, Rockman, Tom C, Kotsimbos, Allen C, Cheng, Michael, Richards, Glen P, Westall, Linda M, Wakim, Thomas, Loudovaris, Stuart I, Mannering, Michael, Elliott, Stuart G, Tangye, David C, Jackson, Katie L, Flanagan, Jamie, Rossjohn, Stephanie, Gras, Jane, Davies, Adrian, Miller, Steven Y C, Tong, Anthony W, Purcell, Katherine, Kedzierska
Publikováno v:
Nature Communications
Indigenous people worldwide are at high risk of developing severe influenza disease. HLA-A*24:02 allele, highly prevalent in Indigenous populations, is associated with influenza-induced mortality, although the basis for this association is unclear. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::907a4cc518ea8a1e781f9d48c37d044f
https://pubmed.ncbi.nlm.nih.gov/34006841
https://pubmed.ncbi.nlm.nih.gov/34006841
Autor:
M. Koutsakos, L. Rowntree, L. Hensen, B. Chua, C. van de Sandt, Jennifer R. Habel, Wuji Zhang, Xiaoxiao Jia, Lukasz Kedzierski, Thomas M. Ashhurst, G. Putri, Felix Marsh-Wakefield, Read MN, Davis N. Edwards, Bridie E. Clemens, Chinn Yi Wong, Francesca L. Mordant, Jennifer A. Juno, Fatima Amanat, Jennifer Audsley, Natasha E. Holmes, Carly M. Hughes, Mike Catton, Justin Denholm, Steven Tong, Denise L. Doolan, Tom C. Kotsimbos, David C. Jackson, Florian Krammer, Dale Godfrey, Chung AW, Nicholas J.C. King, Sharon R. Lewin, Adam K. Wheatley, Stephen J. Kent, Kanta Subbarao, James McMahon, Irani Thevarajan, Thi H.O. Nguyen, Cheng AC, Katherine Kedzierska
Publikováno v:
SSRN Electronic Journal.
SARS-CoV-2 causes a spectrum of illness, ranging from asymptomatic to severe COVID-19. As the immunological basis for severity remains ill-defined, we analysed 78 SARS-CoV-2-infected individuals at acute and/or convalescent timepoints, up to 102 days
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9bd305af0a05c72d311dcc987fcaac5f
https://doi.org/10.2139/ssrn.3701261
https://doi.org/10.2139/ssrn.3701261
Autor:
Marios, Koutsakos, Patricia T, Illing, Thi H O, Nguyen, Nicole A, Mifsud, Jeremy Chase, Crawford, Simone, Rizzetto, Auda A, Eltahla, E Bridie, Clemens, Sneha, Sant, Brendon Y, Chua, Chinn Yi, Wong, E Kaitlynn, Allen, Don, Teng, Pradyot, Dash, David F, Boyd, Ludivine, Grzelak, Weiguang, Zeng, Aeron C, Hurt, Ian, Barr, Steve, Rockman, David C, Jackson, Tom C, Kotsimbos, Allen C, Cheng, Michael, Richards, Glen P, Westall, Thomas, Loudovaris, Stuart I, Mannering, Michael, Elliott, Stuart G, Tangye, Linda M, Wakim, Jamie, Rossjohn, Dhanasekaran, Vijaykrishna, Fabio, Luciani, Paul G, Thomas, Stephanie, Gras, Anthony W, Purcell, Katherine, Kedzierska
Publikováno v:
Nature immunology. 20(5)
Influenza A, B and C viruses (IAV, IBV and ICV, respectively) circulate globally and infect humans, with IAV and IBV causing the most severe disease. CD8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::482d97fcc7584bca99753b5051f4d17f
https://pubmed.ncbi.nlm.nih.gov/30778243
https://pubmed.ncbi.nlm.nih.gov/30778243
Autor:
Luca Hensen, Patricia T. Illing, E. Bridie Clemens, Thi H. O. Nguyen, Marios Koutsakos, Carolien E. van de Sandt, Nicole A. Mifsud, Andrea T. Nguyen, Christopher Szeto, Brendon Y. Chua, Hanim Halim, Simone Rizzetto, Fabio Luciani, Liyen Loh, Emma J. Grant, Phillipa M. Saunders, Andrew G. Brooks, Steve Rockman, Tom C. Kotsimbos, Allen C. Cheng, Michael Richards, Glen P. Westall, Linda M. Wakim, Thomas Loudovaris, Stuart I. Mannering, Michael Elliott, Stuart G. Tangye, David C. Jackson, Katie L. Flanagan, Jamie Rossjohn, Stephanie Gras, Jane Davies, Adrian Miller, Steven Y. C. Tong, Anthony W. Purcell, Katherine Kedzierska
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
The immunology of Indigenous populations is generally understudied outside the context of diseases that are prevalent in these communities. Here the authors identify prevalence of influenza CD8+ T cell epitopes in an Indigenous Australian population
Externí odkaz:
https://doaj.org/article/a3a6a4c017e544c7b83819f5cde0c3d5
Autor:
Thi H. O. Nguyen, Marios Koutsakos, Carolien E. van de Sandt, Jeremy Chase Crawford, Liyen Loh, Sneha Sant, Ludivine Grzelak, Emma K. Allen, Tim Brahm, E. Bridie Clemens, Maria Auladell, Luca Hensen, Zhongfang Wang, Simone Nüssing, Xiaoxiao Jia, Patrick Günther, Adam K. Wheatley, Stephen J. Kent, Malet Aban, Yi-Mo Deng, Karen L. Laurie, Aeron C. Hurt, Stephanie Gras, Jamie Rossjohn, Jane Crowe, Jianqing Xu, David Jackson, Lorena E. Brown, Nicole La Gruta, Weisan Chen, Peter C. Doherty, Stephen J. Turner, Tom C. Kotsimbos, Paul G. Thomas, Allen C. Cheng, Katherine Kedzierska
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The immunological parameters that define severe influenza disease are not clear within human real time infections. Here the authors compare a severe influenza infection cohort with an influenza vaccinated cohort to understand correlates of severe inf
Externí odkaz:
https://doaj.org/article/2bb8c377813f4ec9954ac0d874794b8f