Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Tom C, Hobman"'
Autor:
Ryley D. McClelland, Yi-Chan James Lin, Tyce N. Culp, Ryan Noyce, David Evans, Tom C. Hobman, Vanessa Meier-Stephenson, David J. Marchant
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
IntroductionThe COVID-19 pandemic was caused by the zoonotic betacoronavirus SARS-CoV-2. SARS-CoV-2 variants have emerged due to adaptation in humans, shifting SARS-CoV-2 towards an endemic seasonal virus. We have termed this process ‘virus domesti
Externí odkaz:
https://doaj.org/article/8a834cf72cf643a2b2c319f1778d5372
Autor:
Robert Lodge, Zaikun Xu, Mckenna Eklund, Christina Stürzel, Frank Kirchhoff, Michel J. Tremblay, Tom C. Hobman, Éric A. Cohen
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT The type 1 interferon-regulated E3 ubiquitin ligase MARCH1 reduces surface expression of HIV-1 envelope glycoproteins (Env) and their packaging into nascent virions, a condition that restricts viral infectivity. However, how HIV-1 counters t
Externí odkaz:
https://doaj.org/article/d691c612579c4ccfb0b25dd7e74b1bb7
Autor:
Samer Girgis, Zaikun Xu, Spyros Oikonomopoulos, Alla D. Fedorova, Egor P. Tchesnokov, Calvin J. Gordon, T. Martin Schmeing, Matthias Götte, Nahum Sonenberg, Pavel V. Baranov, Jiannis Ragoussis, Tom C. Hobman, Jerry Pelletier
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Genomes from defective interfering (DI) particles following serial passaging of SARS-CoV-2 reveal a fusion protein that attenuates viral replication. Synthetic, recombinant DI genomes are designed to interfere with SARS-CoV-2 replication.
Externí odkaz:
https://doaj.org/article/5e493b54c37c47c3a8ea41d5c87f53e3
Autor:
Luke Gerla, Subhabrata Moitra, Desmond Pink, Natasha Govindasamy, Marc Duchesne, Eileen Reklow, Angela Hillaby, Amy May, John D. Lewis, Lyle Melenka, Tom C. Hobman, Irvin Mayers, Paige Lacy
Publikováno v:
Viruses, Vol 15, Iss 2, p 556 (2023)
Thymic stromal lymphopoietin (TSLP) is an epithelium-derived pro-inflammatory cytokine involved in lung inflammatory responses. Previous studies show conflicting observations in blood TSLP in COVID-19, while none report SARS-CoV-2 inducing TSLP expre
Externí odkaz:
https://doaj.org/article/e8ea41dd651f43b3a3721bfaf8c17491
Autor:
Adriana M. Airo, Alberto Felix-Lopez, Valeria Mancinelli, Danyel Evseev, Joaquin Lopez-Orozco, Kathy Shire, Patrick Paszkowski, Lori Frappier, Katharine E. Magor, Tom C. Hobman
Publikováno v:
Viruses, Vol 14, Iss 5, p 968 (2022)
Zika virus (ZIKV) establishes persistent infections in multiple human tissues, a phenomenon that likely plays a role in its ability to cause congenital birth defects and neurological disease. Multiple nonstructural proteins encoded by ZIKV, in partic
Externí odkaz:
https://doaj.org/article/e9dd4fea08f24773acb3200a539d2344
Autor:
Shu Y. Luo, Eman W. Moussa, Joaquin Lopez-Orozco, Alberto Felix-Lopez, Ray Ishida, Nawell Fayad, Erik Gomez-Cardona, Henry Wang, Joyce A. Wilson, Anil Kumar, Tom C. Hobman, Olivier Julien
Publikováno v:
ACS Infectious Diseases. 9:749-761
Publikováno v:
mBio, Vol 11, Iss 2 (2020)
ABSTRACT Human immunodeficiency virus type 1 (HIV-1) establishes lifelong infections in humans, a process that relies on its ability to thwart innate and adaptive immune defenses of the host. Recently, we reported that HIV-1 infection results in a dr
Externí odkaz:
https://doaj.org/article/006b52600c4f4fdaae933574a259397e
Autor:
Ray Ishida, Jamie Cole, Joaquin Lopez-Orozco, Nawell Fayad, Alberto Felix-Lopez, Mohamed Elaish, Shu Yue Luo, Olivier Julien, Anil Kumar, Tom C. Hobman
Publikováno v:
Cells, Vol 10, Iss 12, p 3510 (2021)
Mayaro virus (MAYV) is an emerging mosquito-transmitted virus that belongs to the genus Alphavirus within the family Togaviridae. Humans infected with MAYV often develop chronic and debilitating arthralgia and myalgia. The virus is primarily maintain
Externí odkaz:
https://doaj.org/article/4fb877e8f6104ed2941e04be48370d58
Publikováno v:
Viruses, Vol 13, Iss 1, p 29 (2020)
The ongoing pandemic of coronavirus disease 2019 (COVID-19) caused by the acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) poses a persistent threat to global public health. Although primarily a respiratory illness, extrapulmonary manifestations
Externí odkaz:
https://doaj.org/article/22c1924fe2894fe2b1b729b0f65313a7
Autor:
Daniel Limonta, Tom C. Hobman
Publikováno v:
Cells, Vol 9, Iss 11, p 2463 (2020)
Before the emergence of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), the causative agent of the current COVID-19 (coronavirus disease 2019) pandemic [...]
Externí odkaz:
https://doaj.org/article/2c3012ec01644c31a3ef3f8e3c2ceeba