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pro vyhledávání: '"Tom Bray"'
Autor:
Jonathan Hayward, Artemij Fedosejev, Narayan Prusty, Adam Horton, Ryan Vice, Ethan Holmes, Tom Bray
Master the art of building dynamic, modern web applications with ReactAbout This BookLearn the hot new frontend web framework from Facebook – ReactJS, an easy way of developing the V in MVC and a better approach to software engineering in JavaScrip
Autor:
Ethan Holmes, Tom Bray
Learn to build modern native iOS and Android applications using JavaScript and the incredible power of ReactKey Features[•]Learn to design and build a fully-featured application using the newest cutting-edge framework from Facebook[•]Leverage you
Autor:
Ming Zhao, Haiyan Zhao, David A. Matthews, Kottayil I. Varughese, Rose Ann Ferre, Tom Bray, John M. Whiteley, Marc Ouellette
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 59:1539-1544
The protozoan parasites Leishmania utilize a pteridine-reducing enzyme, pteridine reductase (PTR1), to bypass antifolate inhibition. The crystal structure of PTR1 from L. tarentolae has been solved as a binary complex with NADPH at 2.8 A resolution.
Autor:
Marc Ouellette, Tom Bray, John M. Whiteley, Jingyu Wang, Éric Leblanc, Barbara Papadopoulou, Sheng-Xiang Lin, Chi-Feng Chang
Publikováno v:
Archives of Biochemistry and Biophysics. 342:197-202
Overproduction of the short-chain dehydrogenase/reductase PTR1 confers resistance to the dihydrofolate reductase inhibitor methotrexate in the protozoan parasite Leishmania. Genetic analysis has previously implicated PTR1 in pterin and folate metabol
Autor:
Kottayil I. Varughese, John M. Whiteley, Poonam Gupta, Philip M. Kiefer, Ying Su, Chi-F. Chang, Tom Bray, N.H. Xuong
Publikováno v:
Journal of Biological Chemistry. 271:3437-3444
Nine single genetic mutants of rat dihydropteridine reductase (EC 1.6.99.7), D37I, W86I, Y146F, Y146H, K150Q, K150I, K150M, N186A, and A133S and one double mutant, Y146F/K150Q, have been engineered, overexpressed in Escherichia coli and their protein
Autor:
Tom Bray, M. Skinner, Kottayil I. Varughese, Nguyen-Huu Xuong, D.A. Matthews, James A. Hoch, J. M. Whiteley, C E Grimshaw
Publikováno v:
Journal of Biological Chemistry. 267:15334-15339
Kinetic constants for the interaction of NADH and NADPH with native rat dihydropteridine reductase (DHPR) and an Escherichia coli expressed mutant (D-37-I) have been determined. Comparison of kcat and Km values measured employing quinonoid 6,7-dimeth
Publikováno v:
Archives of biochemistry and biophysics. 368(1)
PTR1, the gene promoting MTX resistance following gene amplification or DNA transfection in Leishmania tarentolae and selected mutants, has been cloned and heavily overexpressed (>100 mg/liter) in Escherichia coli strain BL21 (DE3). Protein has been
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781461371465
Naturally occurring pteridines in eukaryotic systems usually contain 2-amino, 4-hydroxy 6-alkyl substituents composed of either a methylene-p-aminobenzoylglutamate (or polutamate) or a dihydroxypropyl group. The former class are known collectively as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e46f629432e30d6557a593f0cf1582c
https://doi.org/10.1007/978-1-4615-4735-8_50
https://doi.org/10.1007/978-1-4615-4735-8_50