Fluorescent base analogues in gapmers enable stealth labeling of antisense oligonucleotide therapeutics

Autor: Jesper R. Nilsson, Tom Baladi, Audrey Gallud, Dženita Baždarević, Malin Lemurell, Elin K. Esbjörner, L. Marcus Wilhelmsson, Anders Dahlén

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)

Abstract To expand the antisense oligonucleotide (ASO) fluorescence labeling toolbox beyond covalent conjugation of external dyes (e.g. ATTO-, Alexa Fluor-, or cyanine dyes), we herein explore fluorescent base analogues (FBAs) as a novel approach to

Externí odkaz: https://doaj.org/article/8abf403a3bcb4d9fa1479c960effbb9d

Stealth fluorescence labeling for live microscopy imaging of mRNA delivery

Autor: Elin K. Esbjörner, Jesper R. Nilsson, Audrey Gallud, Marcel Hollenstein, Cécile Gasse, Emanuele Celauro, Anders Dahlén, Fabienne Levi-Acobas, Tom Baladi, Ivo Sarac, L. Marcus Wilhelmsson

Publikováno v: Journal of the American Chemical Society
Journal of the American Chemical Society, 2021, 143 (14), pp.5413-5424. ⟨10.1021/jacs.1c00014⟩
Journal of the American Chemical Society, American Chemical Society, 2021, 143 (14), pp.5413-5424. ⟨10.1021/jacs.1c00014⟩

International audience; Methods for tracking RNA molecules inside living cells without perturbing their natural interactions and functions are critical within biology and, in particular, to facilitate studies of therapeutic RNA delivery. We present a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b7d2187355619e1957adc2defc6f7db
https://doi.org/10.1101/2020.07.01.172767

Design, synthesis, biological evaluation and cellular imaging of imidazo[4,5-b]pyridine derivatives as potent and selective TAM inhibitors

Autor: Sandrine Piguel, Ting-Di Wu, François Radvanyi, Jean-Luc Guerquin-Kern, Florent Dufour, Jessy Aziz, Florent Poyer, Valentina Abet, Isabelle Bernard-Pierrot, Sergio Marco Garrido, Tom Baladi, Véronique Stoven

Publikováno v: Bioorganic & Medicinal Chemistry Letters
Bioorganic & Medicinal Chemistry Letters, 2018, 26 (20), pp.5510-5530. ⟨10.1016/j.bmc.2018.09.031⟩
Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry, Elsevier, 2018, 26 (20), pp.5510-5530. ⟨10.1016/j.bmc.2018.09.031⟩

The TAM kinase family arises as a new effective and attractive therapeutic target for cancer therapy, autoimmune and viral diseases. A series of 2,6-disubstituted imidazo[4,5-b]pyridines were designed, synthesized and identified as highly potent TAM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fbad46ed6ac0bb4faf81275e51e4dee
https://hal.archives-ouvertes.fr/hal-03116869

ChemInform Abstract: Microwave-Assisted C-2 Direct Alkenylation of Imidazo[4,5-b]pyridines: Access to Fluorescent Purine Isosteres with Remarkably Large Stokes Shifts

Autor: Anton Granzhan, Tom Baladi, Sandrine Piguel

Publikováno v: ChemInform. 47

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cb9cac52328214cd5f4c86bee74db726
https://doi.org/10.1002/chin.201639168

State-of-the-art of small molecule inhibitors of the TAM family: the point of view of the chemist

Autor: Valentina Abet, Sandrine Piguel, Tom Baladi

Publikováno v: European journal of medicinal chemistry. 105

The TAM family of tyrosine kinases receptors (Tyro3, Axl and Mer) is implicated in cancer development, autoimmune reactions and viral infection and is therefore emerging as an effective and attractive therapeutic target. To date, only a few small mol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43056a83217f671b00e63caca4ef6de5
https://pubmed.ncbi.nlm.nih.gov/26498569