Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Tom Ashmore"'
Autor:
Lorna B. Jarvis, Daniel B. Rainbow, Valerie Coppard, Sarah K. Howlett, Zoya Georgieva, Jessica L. Davies, Harpreet Kaur Mullay, Joanna Hester, Tom Ashmore, Aletta Van Den Bosch, James T. Grist, Alasdair J. Coles, Hani S. Mousa, Stefano Pluchino, Krishnaa T. Mahbubani, Julian L. Griffin, Kourosh Saeb-Parsy, Fadi Issa, Luca Peruzzotti-Jametti, Linda S. Wicker, Joanne L. Jones
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Jarvis et al demonstrate that expanded human Tregs switch their metabolism to aerobic glycolysis and show enhanced suppressive function through hypoxia-inducible factor 1-alpha (HIF1A)-driven acquisition of CD73 expression, which along with CD39, ena
Externí odkaz:
https://doaj.org/article/45140660645e4b33867eb3d5efef93f6
Autor:
Zoe Hall, Catherine H. Wilson, Deborah L. Burkhart, Tom Ashmore, Gerard I. Evan, Julian L. Griffin
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 11, Pp 1390-1399 (2020)
Nonsmall cell lung cancer (NSCLC) is a leading cause of cancer-related deaths. While mutations in Kras and overexpression of Myc are commonly found in patients, the role of altered lipid metabolism in lung cancer and its interplay with oncogenic Myc
Externí odkaz:
https://doaj.org/article/94731872d8ec41e79cf6a6bed5eb809f
Autor:
Zsuzsanna Ament, James A. West, Elizabeth Stanley, Xuefei Li, Tom Ashmore, Lee D. Roberts, Jayne Wright, Andrew W. Nicholls, Julian L. Griffin
Publikováno v:
Data in Brief, Vol 8, Iss , Pp 196-202 (2016)
This article contains mass spectrometry (MS) data investigating small molecule changes as an effect of a triple peroxisome proliferator-activated receptor (PPAR-pan) agonist GW625019 in the liver as described in the manuscript (Ament et al., 2016) [1
Externí odkaz:
https://doaj.org/article/7f227b95d5d14a85aab124682e91c7b2
Autor:
Julian L. Griffin, Gerard I. Evan, Trevor Littlewood, Albert Koulman, Tom Ashmore, Deborah L. Burkhart, Catherine H. Wilson, Zsuzsanna Ament, Zoe Hall
Figure legends for supplemental Figures S1-S6.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::459bb0114244c72875e0d65f6ab33318
https://doi.org/10.1158/0008-5472.22410902.v1
https://doi.org/10.1158/0008-5472.22410902.v1
Autor:
Julian L. Griffin, Gerard I. Evan, Trevor Littlewood, Albert Koulman, Tom Ashmore, Deborah L. Burkhart, Catherine H. Wilson, Zsuzsanna Ament, Zoe Hall
Liquid extraction surface analysis mass spectrometry differentiates normal from tumour tissue.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5be781ad5a263dcc5b2ad4b43efb3ed
https://doi.org/10.1158/0008-5472.22410914.v1
https://doi.org/10.1158/0008-5472.22410914.v1
Autor:
Julian L. Griffin, Gerard I. Evan, Trevor Littlewood, Albert Koulman, Tom Ashmore, Deborah L. Burkhart, Catherine H. Wilson, Zsuzsanna Ament, Zoe Hall
MYC-mediated pathogenesis in lung cancer continues to attract interest for new therapeutic strategies. In this study, we describe a transgenic mouse model of KRAS-driven lung adenocarcinoma that affords reversible activation of MYC, used here as a to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c856fd3197712afcbc9dfb3dddd2b2c1
https://doi.org/10.1158/0008-5472.c.6508106.v1
https://doi.org/10.1158/0008-5472.c.6508106.v1
Autor:
Julian L. Griffin, Gerard I. Evan, Trevor Littlewood, Albert Koulman, Tom Ashmore, Deborah L. Burkhart, Catherine H. Wilson, Zsuzsanna Ament, Zoe Hall
LC-MS/MS method details for eicosanoid analysis (Tables S1 and S2); Lipid ID by accurate mass and tandem MS (Tables S3 and S4); Fold change for eicosanoid-related species with MYC activated (Table S5).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f8e9f1fc1d99bd0f466a9dd68b12f9b
https://doi.org/10.1158/0008-5472.22410899
https://doi.org/10.1158/0008-5472.22410899
Autor:
Lorna Jarvis, Daniel Rainbow, Valerie Coppard, Sarah Howlett, Jessica Davies, Harpreet Mullay, Joanna Hester, Tom Ashmore, Aletta Van Den Bosch, James Grist, Alasdair Coles, Hani Mousa, Stefano Pluchino, Krishnaa Mahbubani, Julian Griffin, Kourosh Saeb-Parsy, Fadi Issa, Luca Peruzzotti-Jametti, Linda Wicker, Joanne Jones
The adoptive transfer of regulatory T-cells (Tregs) is a promising therapeutic approach in transplantation and autoimmunity. However, because large cell numbers are needed to achieve a therapeutic effect, in vitro expansion is required. By comparing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5efe9dd65a5c327360df86e632c678a
https://doi.org/10.21203/rs.3.rs-92789/v1
https://doi.org/10.21203/rs.3.rs-92789/v1
Autor:
Daniel B. Rainbow, Lorna B. Jarvis, Valerie Coppard, Hani S Mousa, Joanne L. Jones, Alasdair Coles, Zoya Georgieva, Fadi Issa, Kourosh Saeb-Parsy, Krishnaa T. Mahbubani, Stefano Pluchino, Tom Ashmore, Sarah Howlett, Julian L. Griffin, Luca Peruzzotti-Jametti, Linda S. Wicker, Aletta Van Den Bosch, Joanna Hester, Harpreet Kaur Mullay, James T. Grist, Jessica L. Davies
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
The adoptive transfer of regulatory T-cells (Tregs) is a promising therapeutic approach in transplantation and autoimmunity. However, because large cell numbers are needed to achieve a therapeutic effect, in vitro expansion is required. By comparing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bbb0f51688879fe919b945878fdba9a
https://pubmed.ncbi.nlm.nih.gov/34650224
https://pubmed.ncbi.nlm.nih.gov/34650224
Autor:
Julian L. Griffin, Catherine H. Wilson, Zoe Hall, Tom Ashmore, Gerard I. Evan, Deborah L. Burkhart
Publikováno v:
J Lipid Res
Journal of Lipid Research, Vol 61, Iss 11, Pp 1390-1399 (2020)
Journal of Lipid Research, Vol 61, Iss 11, Pp 1390-1399 (2020)
Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related deaths. Whilst mutations in Kras and over-expression of Myc are commonly found in patients, the role of altered lipid metabolism in lung cancer and its interplay with oncogenic M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bada369e1e77649efcdba88fd4ed12df
https://pubmed.ncbi.nlm.nih.gov/32753459
https://pubmed.ncbi.nlm.nih.gov/32753459