In Response: Some species sensitivity distribution statistics revisited-A governmental perspective

Autor: Tom Aldenberg

Publikováno v: Environmental Toxicology and Chemistry. 34:2442-2444

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37815144d3e93d1ee15482d3acb793c9
https://doi.org/10.1002/etc.3109

Towards optimization of chemical testing under REACH: A Bayesian network approach to Integrated Testing Strategies

Autor: Silke Gabbert, Tom Aldenberg, Joanna Jaworska

Publikováno v: Regulatory Toxicology and Pharmacology, 57(2-3), 157-167
Regulatory Toxicology and Pharmacology 57 (2010) 2-3

Integrated Testing Strategies (ITSs) are considered tools for guiding resource efficient decision-making on chemical hazard and risk management. Originating in the mid-nineties from research initiatives on minimizing animal use in toxicity testing, I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95d555f1eb4bdba740df7e7539ab363f
https://doi.org/10.1016/j.yrtph.2010.02.003

Current Status of Methods for Defining the Applicability Domain of (Quantitative) Structure-Activity Relationships

Autor: Romualdo Benigni, Tatiana I. Netzeva, Gilman Veith, Terry W Schultz, Roger Perkins, Gilles Klopman, Johannes J.M. van de Sandt, Nina Nikolova-Jeliazkova, Andrew Worth, Joanna Jaworska, David W. Roberts, Mark T. D. Cronin, Glenn J. Myatt, Carol A. Marchant, Chihae Yang, Weida Tong, Paola Gramatica, Tom Aldenberg, Scott Kahn, Grace Patlewicz, David T. Stanton

Publikováno v: Alternatives to Laboratory Animals. 33:155-173

This is the 52nd report of a series of workshops organised by the European Centre for the Validation of Alternative Methods (ECVAM). The main objective of ECVAM, as defined in 1993 by its Scientific Advisory Committee, is to promote the scientific an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2146edd395bd8d7dd7b816fec78b6076
https://doi.org/10.1177/026119290503300209

Congener-specific model for polychlorinated biphenyl effects on otter (Lutra lutra) and associated sediment quality criteria

Autor: Tom Aldenberg, Olivier Klepper, Robert Luttik, M.D. Smit, Jacobus E. M. Beurskens, Theo P. Traas, Albertus G. M. van Hattum, Pim E.G. Leonards

Publikováno v: Traas, T P, Luttik, R, Klepper, O, Beurskens, J E M, Smit, M D, Leonards, P E G, van Hattum, A G M & Aldenberg, T 2001, ' Congener-specific model for polychlorinated biphenyl effects on otter (Lutra lutra) and associated sediment quality criteria ', Environmental Toxicology and Chemistry, vol. 20, pp. 205-212 . https://doi.org/10.1897/1551-5028(2001)020<0205:CSMFPB>2.0.CO;2
Environmental Toxicology and Chemistry, 20(1), 205-212
Environmental Toxicology and Chemistry 20 (2001) 1
Environmental Toxicology and Chemistry, 20, 205-212. John Wiley and Sons Ltd

A model for risk assessment was built for simultaneous, congener-specific PCB bioaccumulation from sediment to fish to otters (Lutra lutra). Toxic equivalence factors (TEFs) were used to sum individual congeners in otters to a toxic equivalent concen

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https://doi.org/10.1002/etc.5620200124

Extrapolation factors for small samples of pesticide toxicity data: Special focus on LD50 values for birds and mammals

Autor: Tom Aldenberg, Robert Luttik

Publikováno v: Environmental Toxicology and Chemistry. 16:1785-1788

For the registration procedure of pesticides it is necessary to have specific information and testing data in order to conduct an ecological hazard/risk assessment. The hazard/risk assessment for acute exposure is usually based on a quotient method,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e5e89c73d6391c8b3bc45963de6561ba
https://doi.org/10.1002/etc.5620160904